Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics

Jiang, Li; Dai, Jundong; Zhen-lin, Huang; Du, Quan; Lin, Jiahao; Wang, Yurong

doi:10.1016/j.jchromb.2012.12.011

Cited by 42 publications

(24 citation statements)

References 18 publications

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“…On one hand, it reached the T max at 18.33, 12.50 and 14.17 min, respectively, after oral administration of GR extract at low, middle and high levels of doses and eliminated rapidly from the plasma. The data were found to be similar to those that were reported in publications [22,23]. On the other hand, the compound reached the T max at 18.33, 25.00 and 40.83 min, respectively, after oral administration of GR powder at low, middle and high levels of doses.…”

Section: Application To Pharmacokinetic Studiessupporting

confidence: 88%

Relative bioavailability of gastrodin and parishin from extract and powder of Gastrodiae rhizoma in rat

Zhao

Gong

Zhou

et al. 2014

Journal of Pharmaceutical and Biomedical Analysis

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Section: Application To Pharmacokinetic Studiessupporting

confidence: 88%

Relative bioavailability of gastrodin and parishin from extract and powder of Gastrodiae rhizoma in rat

Zhao

Gong

Zhou

et al. 2014

Journal of Pharmaceutical and Biomedical Analysis

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“…The pharmacokinetic parameters calculated from the data are summarized in Table 2. Plasma levels of puerarin declined rapidly in control group given puerarin only, which was consistent with previous result [21]. …”

Section: Resultssupporting

confidence: 93%

“…The dose-dependent relationships of C max⁡ , T max⁡ , and AUC 0– ∞ are depicted in Figure 4. In the control group given puerarin only, the pharmacokinetic parameters of puerarin in our study was partially consistent with the result of Jiang et al [21], in which puerarin also displayed a low C max⁡ , short t 1/2 , and high CL after oral administration.…”

Section: Resultssupporting

confidence: 91%

White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats

Liang

Chen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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This study attempted to explore the effects of white pepper and its major component piperine on puerarin administered to rats. Pharmacokinetic parameters of puerarin in rats were determined by oral administration (400 mg/kg) or intravenous injection (40 mg/kg) of puerarin, pretreated with or without white pepper and piperine given orally. Compared to the control group given oral puerarin only, the combined use of piperine (10 or 20 mg/kg) increased the C max of puerarin by 1.30-fold or 1.64-fold and the AUC0–∞ by 133% or 157%, respectively. In contrast, coadministration of white pepper (125 or 250 mg/kg) decreased oral absorption of puerarin to 83% or 74%, respectively. On the other hand, pretreatment with piperine orally did not alter the intravenous pharmacokinetics of puerarin, while the AUC of puerarin after intravenous administration was increased by pretreatment with white pepper. The results indicate that pretreatment with piperine or pepper exerts different effects on pharmacokinetics of puerarin administrated via intragastric and intravenous routes. Therefore, it is suggested that the combined application of piperine or white pepper with puerarin should be carefully monitored for potential diet-drug interactions.

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“…However, due to the short elimination half-life in human beings, it is necessary to administer frequent or high doses, which leads to severe side effects and restricts its clinical application [10, 11]. Thus, oral formulation with improved absorption of puerarin has attracted widespread attention.…”

Section: Introductionmentioning

confidence: 99%

A Novel Microspheres Formulation of Puerarin: Pharmacokinetics Study and In Vivo Pharmacodynamics Evaluations

Song

Bai

Liu

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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The aim of this study was to investigate the pharmacokinetics and pharmacodynamics of puerarin loaded carboxymethyl chitosan microspheres (Pue-CCMs). The differences in pharmacokinetics parameters of rats after intragastric administration of Pue-CCMs and puerarin were investigated using HPLC. To assess the protective effect of Pue-CCMs on myocardial injury in rats, serum levels of creatine kinase (CK), lactate dehydrogenase (LDH), total superoxide dismutase (T-SOD), and malondialdehyde (MDA) were measured, in addition to pathological examinations and immunohistochemical staining. Our present study has shown that the AUC0–t, Cmax, Tmax, MRT0–t of Pue-CCMs, and puerarin were 20.176 mg·h/L, 3.778 μg/mL, 1 h, 4.634 h and 9.474 mg·h/L, 2.618 μg/mL, 0.542 h, and 3.241 h, respectively. Pue-CCMs alleviated myocardial ischemic injury. Pretreatment with Pue-CCMs could significantly decrease CK, LDH, and MDA levels and increase T-SOD level in the serum. Pue-CCMs downregulated expression of the Bcl-2 associated X protein (Bax) and upregulated B-cell lymphoma-2 (Bcl-2) expression. Compared with puerarin group, the Pue-CCMs group could improve the oral bioavailability of puerarin. The protective effect of Pue-CCMs against myocardial injury was significantly greater than puerarin at the same dose. In summary, Pue-CCMs should be a qualified and promising candidate as a new oral preparation of puerarin.

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Simultaneous determination of gastrodin and puerarin in rat plasma by HPLC and the application to their interaction on pharmacokinetics

Cited by 42 publications

References 18 publications

Relative bioavailability of gastrodin and parishin from extract and powder of Gastrodiae rhizoma in rat

Relative bioavailability of gastrodin and parishin from extract and powder of Gastrodiae rhizoma in rat

White Pepper and Piperine Have Different Effects on Pharmacokinetics of Puerarin in Rats

A Novel Microspheres Formulation of Puerarin: Pharmacokinetics Study and In Vivo Pharmacodynamics Evaluations

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