Association between dietary phylloquinone intake and peripheral metabolic risk markers related to insulin resistance and diabetes in elderly subjects at high cardiovascular risk

Abstract

BackgroundVitamin K has been related to glucose metabolism, insulin sensitivity and diabetes. Because inflammation underlies all these metabolic conditions, it is plausible that the potential role of vitamin K in glucose metabolism occurs through the modulation of cytokines and related molecules. The purpose of the study was to assess the associations between dietary intake of vitamin K and peripheral adipokines and other metabolic risk markers related to insulin resistance and type 2 diabetes mellitus.MethodsCross-sectional and longitudinal assessments of these associations in 510 elderly participants recruited in the PREDIMED centers of Reus and Barcelona (Spain). We determined 1-year changes in dietary phylloquinone intake estimated by food frequency questionnaires, serum inflammatory cytokines and other metabolic risk markers.ResultsIn the cross-sectional analysis at baseline no significant associations were found between dietary phylloquinone intake and the rest of metabolic risk markers evaluated, with exception of a negative association with plasminogen activator inhibitor-1. After 1-year of follow-up, subjects in the upper tertile of changes in dietary phylloquinone intake showed a greater reduction in ghrelin (−15.0%), glucose-dependent insulinotropic peptide (−12.9%), glucagon-like peptide-1 (−17.6%), IL-6 (−27.9%), leptin (−10.3%), TNF (−26.9%) and visfatin (−24.9%) plasma concentrations than those in the lowest tertile (all p<0.05).ConclusionThese results show that dietary phylloquinone intake is associated with an improvement of cytokines and other markers related to insulin resistance and diabetes, thus extending the potential protection by dietary phylloquinone on chronic inflammatory diseases.Trial registrationhttp://www.controlled-trials.com as ISRCTN35739639

Diabetes and Oxidative Stress

“…Vitamin K (500 μm/day) supplementation has also been found to be beneficial in lowering fasting insulin concentrations and insulin resistance in older nondiabetic individuals [47]. In one study of 510 subjects, the authors observed that dietary phylloquinone uptake was associated with an improvement of cytokines and other markers related to insulin resistance and diabetes [48]. Hypomagnesemia has been reported in patients with type 2 diabetes.…”

The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis

“…In a secondary analysis of the PREDIMED trial, a Mediterranean diet intervention being conducted in Spain, (n= 510; mean age = 67.2±6 years) participants who increased their dietary phylloquinone intake the most (≥70 mcg/d) had the greatest reductions in IL-6, and TNF-α over 1 year. In this analysis, the intervention and control groups were combined, which is not consistent with the RCT design [23]. In both studies [11,23] vitamin K intake was estimated using self-report measures, which are inherently limited (as recently reviewed [24**]).…”

“…In this analysis, the intervention and control groups were combined, which is not consistent with the RCT design [23]. In both studies [11,23] vitamin K intake was estimated using self-report measures, which are inherently limited (as recently reviewed [24**]). Phylloquinone is found in generally healthy foods, so it cannot be discounted that the reported associations reflect a healthy diet rather than phylloquinone intake specifically.…”

Antepfıstığı (Pistacia vera L.) ve İnsan Sağlığı Üzerine Etkileri

“…Antepfıstığı tüketimi ile K vitamininin diyette daha yüksek alımı kemik metabolizmasındaki rolünün [106][107][108] ötesinde Tip 2 diyabet [106], kanser [109,110] [59]. Ayrıca sağlıklı bir diyetle antepfıstığı tüketilmesinin doza bağımlı bir şekilde kardiyovasküler hastalık risk faktörünü etkilediği belirtilmiştir [90].…”