The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis

Harshman, Stephanie; Shea, M. Kyla

doi:10.1007/s13668-016-0162-x

Cited by 75 publications

(72 citation statements)

References 73 publications

(101 reference statements)

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“…Previous studies mostly relied on dietary intake measures of vitamin K such as vitamin K 1 , vitamin K 2 , and natto intake to study the relationship with chronic diseases and CVD [ 3 , 7 , 8 ]. These studies indicated that a high vitamin K intake is associated with improved cardiovascular health.…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies

Ballegooijen

Beulens

2017

Curr Nutr Rep

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Purpose of ReviewVitamin K is a fat-soluble vitamin required for the activation of several vitamin K-dependent proteins to confer functioning. A growing body of evidence supports that vitamin K has beneficial effects on bone and cardiovascular health. This review summarizes key evidence on vitamin K status as measured by circulating measures and cardiovascular outcomes.Recent FindingsOverall, observational studies indicate that low vitamin K status as measured by high dephosphorylated uncarboxylated matrix gla protein concentrations plays a potential role in cardiovascular disease development, particularly in high-risk and chronic kidney disease populations. Very few vitamin K intervention trials have been conducted with cardiovascular-related outcomes. A couple of intervention trials studied the effect of the combination of vitamin D + K supplementation, which might have synergistic effects compared to vitamin K supplementation alone.SummaryAssessing vitamin K status in prospective studies and well-designed randomized trials would provide important insight whether vitamin K is causally related to vascular calcification and cardiovascular disease.

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Section: Introductionmentioning

confidence: 99%

The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies

Ballegooijen

Beulens

2017

Curr Nutr Rep

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“…and coagulation regulatory proteins, the inverse relationship of vitamin K and inflammatory response [97] [98], or the inverse relationship of vitamin K and Interleukin-6 (IL-6) levels [99].…”

Section: Discussionmentioning

confidence: 99%

Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2

Holcomb

Alexaki

Hernandez

et al. 2020

Preprint

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Thrombosis has been one of the complications of the Coronavirus disease of 2019 (COVID-19), often associated with poor prognosis. There is a well-recognized link between coagulation and inflammation, however, the extent of thrombotic events associated with COVID-19 warrants further investigation. Poly(A) Binding Protein Cytoplasmic 4 (PABPC4), Serine/Cysteine Proteinase Inhibitor Clade G Member 1 (SERPING1) and Vitamin K epOxide Reductase Complex subunit 1 (VKORC1), which are all proteins linked to coagulation, have been shown to interact with SARS proteins. We computationally examined the interaction of these with SARS-CoV-2 proteins and, in the case of VKORC1, we describe its binding to ORF7a in detail. We examined the occurrence of variants of each of these proteins across populations and interrogated their potential contribution to COVID-19 severity. Potential mechanisms by which some of these variants may contribute to disease are proposed. Some of these variants are prevalent in minority groups that are disproportionally affected by severe COVID-19. Therefore, we are proposing that further investigation around these variants may lead to better understanding of disease pathogenesis in minority groups and more informed therapeutic approaches.Author summaryIncreased blood clotting, especially in the lungs, is a common complication of COVID-19. Infectious diseases cause inflammation which in turn can contribute to increased blood clotting. However, the extent of clot formation that is seen in the lungs of COVID-19 patients suggests that there may be a more direct link. We identified three human proteins that are involved indirectly in the blood clotting cascade and have been shown to interact with proteins of SARS virus, which is closely related to the novel coronavirus. We examined computationally the interaction of these human proteins with the viral proteins. We looked for genetic variants of these proteins and examined how these variants are distributed across populations. We investigated whether variants of these genes could impact severity of COVID-19. Further investigation around these variants may provide clues for the pathogenesis of COVID-19 particularly in minority groups.

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“…Vascular calcification is a striking feature of chronic inflammatory diseases such as atherosclerosis, type 2 diabetes, and chronic kidney disease (CKD) and is associated with increased risk of adverse CV events [18][19][20][21]. Vitamin K has been proposed to show a protective effect against CVD through the action of VKDPs such as MGP to inhibit vascular calcification [22,23]. Furthermore, anti-inflammatory effects of vitamin K may be involved in preventing progression of atherosclerotic plaque calcification.…”

Section: Introductionmentioning

confidence: 99%

The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification

et al. 2020

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Vitamin K is a fat-soluble vitamin that is indispensable for the activation of vitamin K-dependent proteins (VKDPs) and may be implicated in cardiovascular disease (CVD). Vascular calcification is intimately associated with CV events and mortality and is a chronic inflammatory process in which activated macrophages promote osteoblastic differentiation of vascular smooth muscle cells (VSMCs) through the production of proinflammatory cytokines such as IL-1β, IL-6, TNF-α, and oncostatin M (OSM) in both intimal and medial layers of arterial walls. This process may be mainly mediated through NF-κB signaling pathway. Vitamin K has been demonstrated to exert anti-inflammatory effects through antagonizing NF-κB signaling in both in vitro and in vivo studies, suggesting that vitamin K may prevent vascular calcification via anti-inflammatory mechanisms. Matrix Gla protein (MGP) is a major inhibitor of soft tissue calcification and contributes to preventing both intimal and medial vascular calcification. Vitamin K may also inhibit progression of vascular calcification by enhancing the activity of MGP through facilitating its γ-carboxylation. In support of this hypothesis, the procalcific effects of warfarin, an antagonist of vitamin K, on arterial calcification have been demonstrated in several clinical studies. Among the inactive MGP forms, dephospho-uncarboxylated MGP (dp-ucMGP) may be regarded as the most useful biomarker of not only vitamin K deficiency, but also vascular calcification and CVD. There have been several studies showing the association of circulating levels of dp-ucMGP with vitamin K intake, vascular calcification, mortality, and CVD. However, additional larger prospective studies including randomized controlled trials are necessary to confirm the beneficial effects of vitamin K supplementation on CV health.

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The Role of Vitamin K in Chronic Aging Diseases: Inflammation, Cardiovascular Disease, and Osteoarthritis

Cited by 75 publications

References 73 publications

The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies

The Role of Vitamin K Status in Cardiovascular Health: Evidence from Observational and Clinical Studies

Potential impact on coagulopathy of gene variants of coagulation related proteins that interact with SARS-CoV-2

The Inhibitory Roles of Vitamin K in Progression of Vascular Calcification

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