Réduction des grossesses multiples en AMP par un usage large du SET (Single Embryo Transfer) sur la période 2001–2010

Beraud, E; Brugnon, Florence; Grémeau, Anne-Sophie; Dejou, L.; Pons, Héctor; Janny, L.; Boyer, Cherrie B.; Pouly, Jean-Luc

doi:10.1016/j.gyobfe.2012.09.025

Cited by 5 publications

(3 citation statements)

References 22 publications

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“…The SET policy, encouraged by legislation or public funding and patient and physician education, has led to a drastic decrease in MLBR in many countries: Belgium (Peeraer et al, 2014), Turkey (Kutlu et al, 2011), Canada (Quebec) (Bissonnette et al, 2011), Sweden (Sundström and Saldeen, 2009), Finland (Tiitinen et al, 2003), France (Béraud et al, 2013) and Australia (Chambers et al, 2011). Still, the worldwide uptake of this strategy is variable (Berg Brigham et al, 2013;Busardò et al, 2014;Maheshwari et al, 2011) and the rates of SET across nations vary considerably within Europe and the USA (Dyer et al, 2016;Kupka et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

A 50% reduction in multiple live birth rate is associated with a 13% cost saving: a real-life retrospective cost analysis

Peeraer

D’Hooghe

Vandoren

et al. 2017

Reproductive BioMedicine Online

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Belgian legislation limiting the number of embryos for transfer has been shown to result in a 50% reduction of the multiple live birth rate (MLBR) per cycle without having a negative impact on the cumulative delivery rate per patient within six cycles or 36 months. The objective of the current study was to evaluate the cost saving associated with a 50% reduction in MLBR. A retrospective cost analysis was performed of 213 couples, who became pregnant and had a live birth after one or more assisted reproductive technology treatment cycles, and their 254 children. The mean cost of a singleton (n = 172) and multiple (n = 41) birth was calculated based on individual hospital invoices. The cost analysis showed a significantly higher total cost (assisted reproductive technology treatment, pregnancy follow-up, delivery, child cost until the age of 2 years) for multiple births (both children: mean €43,397) than for singleton births (mean: €17,866) (Wilcoxon-Mann-Whitney P < 0.0001). A 50% reduction in MLBR resulted in a significant cost reduction related to hospital care of 13%.

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Section: Discussionmentioning

confidence: 99%

A 50% reduction in multiple live birth rate is associated with a 13% cost saving: a real-life retrospective cost analysis

Peeraer

D’Hooghe

Vandoren

et al. 2017

Reproductive BioMedicine Online

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“…Dans notre population eSET, les taux de grossesse aprè s TEC n'ont pas é té modifié s, malgré un nombre moyen d'embryons transfé ré s plus bas au fil des ans. Deux é tudes prenant en compte à la fois les ré sultats obtenus aprè s transferts frais et TEC montrent que les taux cumulé s de grossesses sont de 63,9 % dans le groupe eSET incluant jusqu'à trois TEC [14], les taux cumulé s d'accouchements restent stables [7,14] et d'accouchements multiples diminuent aprè s 10 ans d'eSET suivis de TEC [7]. Une ré cente é tude randomisé e a mis en é vidence des taux cumulé s de grossesses et de naissances é quivalents entre un transfert de deux embryons versus un eSET suivi de TEC d'un embryon, sans aucune grossesse gé mellaire dans le groupe eSET [20].…”

Section: Discussionunclassified

“…Depuis 2012, l'American Society for Reproductive Medicine recommande l'eSET chez des patientes de moins de 35 ans ayant plus d'un embryon de bonne qualité (« top ») au cours d'une des deux premiè res tentatives de FIV [6]. En l'absence de grossesse, l'eSET suivi d'un transfert d'embryons congelé s (TEC) offre des chances de grossesses é quivalentes à un transfert de deux embryons tout en diminuant considé rablement le risque de grossesse multiple [7][8][9][10][11]. Ainsi, le risque d'accouchement pré maturé et d'enfant de faible poids de naissance est diminué dans les grossesses uniques obtenues aprè s eSET comparativement à une grossesse aprè s transfert de 2 embryons.…”

Section: Introductionunclassified

Politique de transfert électif d’un embryon à 48/72h : quels résultats après transferts frais et transferts d’embryons congelés ?

Bottin¹,

Achard

Courbiere

et al. 2015

Gynécologie Obstétrique & Fertilité

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Influence of blastocysts morphological score on pregnancy outcomes in frozen-thawed blastocyst transfers: a retrospective study of 741 cycles

Lin

Ding

et al. 2014

J. Huazhong Univ. Sci. Technol. [Med. Sci.]

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The influence of inner cell mass (ICM) and trophectoderm (TE) score on pregnancy outcomes in frozen-thawed blastocyst transfer cycles was analyzed. A retrospective analysis of 741 cycles of frozen-thawed blastosysts transfer was performed. All cycles were divided into four groups based on the number and morphological score of blastocysts: S-ICM B/TE B group (n=91), the single blastocyst transfer of ICM B and TE B; D-ICM B/TE B group (n=579), double blastocysts transfer of ICM B/TE B; D-ICM B/TE C group (n=35), double blastocysts transfer of ICM B/TE C; and D-ICM C/TE B group (n=36), double blastocysts transfer of TE B/ICM C. The pregnancy outcomes were compared among the four groups. As compared with D-ICM B/TE C group, the clinical pregnancy rate, implantation rate and multiple pregnancy rate were increased in D-ICM B/TE B group (74.96% vs. 57.14%, 57.43% vs. 37.14%, and 48.62% vs. 25%, respectively, P<0.05 for all). Clinical pregnancy rate and implantation rate in D-ICM B/TE B group were also higher than in D-ICM C/TE B group (74.96% vs. 50%, and 57.43% vs. 33.33%, both P<0.05). Multivariable Logistic regression analysis indicated that ICM score was a better predictive parameter for clinical pregnancy (OR=3.05, CI 1.70-5.46, P<0.001), while the trophectoderm score was a better one for early abortion (OR=0.074, CI 0.03-0.19, P<0.001). Clinical pregnancy rate and multiple pregnancy rate in S-ICM B/TE B group were significantly lower than those in D-ICM B/TE B group (46.15% vs. 74.96%, and 2.38% vs. 48.62%, both P<0.05), but there was no significant difference in the implantation rate between the two groups. It was suggested that the higher score of ICM and TE may be indicative of the better pregnancy outcomes. The ICM score is a better predictor of clinical pregnancy than TE, while TE score is a better one in predicting early abortion. Single ICM B/TE B blastocyst transfer in frozen-thawed cycles can also get satisfactory pregnancy outcomes.

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Réduction des grossesses multiples en AMP par un usage large du SET (Single Embryo Transfer) sur la période 2001–2010

Cited by 5 publications

References 22 publications

A 50% reduction in multiple live birth rate is associated with a 13% cost saving: a real-life retrospective cost analysis

A 50% reduction in multiple live birth rate is associated with a 13% cost saving: a real-life retrospective cost analysis

Politique de transfert électif d’un embryon à 48/72h : quels résultats après transferts frais et transferts d’embryons congelés ?

Influence of blastocysts morphological score on pregnancy outcomes in frozen-thawed blastocyst transfers: a retrospective study of 741 cycles

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