Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism

Zhang, Xiaochu; Lee, Mary R.; Salmeron, Betty Jo; Stein, Dan J.; Hong, L. Elliot; Geng, Xiujuan; Ross, Thomas J.; Li, Nan; Hodgkinson, Colin A.; Shen, Pei‐Hong; Yang, Yihong; Goldman, David; Stein, Elliot A.

doi:10.1016/j.neuroimage.2012.11.056

Cited by 21 publications

(19 citation statements)

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Section: Resting-state Structural Deficits In Heroin Dependent Indivimentioning

confidence: 99%

“…Numerous imaging studies have shown structural deficits that are associated both gray (Liu et al, 2009a;Yuan et al, 2009Yuan et al, , 2010bWang et al, 2012;Denier et al, 2013a;Qiu et al, 2013) and white matter (Liu et al, 2008;Bora et al, 2010;Wang et al, 2011;Lin et al, 2012;Li et al, 2013c;Zhang et al, 2013) reductions, perfusion's decrement (Denier et al, 2013a(Denier et al, , 2013b, diminished homogeneity and abnormal cortical thickness (Li et al, 2013a). Moreover, few studies associated structural reductions with rsFC impairments (Liu et al, 2009b;Yuan et al, 2009Yuan et al, , 2010aYuan et al, , 2010cMa et al, 2010) despite the fact that their causal relationship remains unknown.…”

Section: Resting-state Structural Deficits In Heroin Dependent Indivimentioning

confidence: 99%

“…Recently the scientific community has witnessed an explosion in the study of functional connectivity modulations (Polunina et al, 2007;Ma et al, 2010Ma et al, , 2011Wang et al, 2010Wang et al, , 2013Yuan et al, 2010a;Xie et al, 2011;Zhang et al, 2011;Moreno-López et al, 2012), structural deficits (Liu et al, 2008(Liu et al, , 2009aYuan et al, 2009Yuan et al, , 2010bBora et al, 2010;Wang et al, 2012;Qiu et al, 2011Qiu et al, , 2013Wang et al, 2011;Lin et al, 2012;Denier et al, 2013a;Zhang et al, 2013;Li et al, 2013aLi et al, , 2013c and changes in topological properties (Liu et al, 2009bYuan et al, 2010c;Jiang et al, 2013) in heroin-dependent individuals at rest.Resting-state is defined as a state that is characterized by the absence of a specific goal-oriented activity or alternatively as a task-free state where the subjects rest quietly awake with their eyes closed, as it has been proposed by Raichle et al (2001). Nevertheless, a more complex baseline or control state such as visual fixation of a cross hair on a monitor or alternatively passive viewing of a stimulus (Greicius et al, 2003;Fox et al, 2005;Fransson, 2006;Fair et al, 2008;Fransson and Marrelec, 2008) is more frequently used.…”

Section: [Figure 1]mentioning

confidence: 99%

“…On the other hand, postmortem tracers have no practical value due to their glacial pace (Sparks et al, 2000). But, researchers are now equipped withmodern imaging technologies such as structural magnetic resonance (Liu et al, 2009a;Wang et al, 2012;Li et al, 2013a) or fMRI associated with voxel-based morphometry approach (Yuan et al, 2010b;Qiu et al, 2013), regional homogeneity tool , pharmacological MRI (phMRI) (Denier et al, 2013a) or fMRI combined to a pulsed arterial spin labeling (Denier et al, 2013b) and quantitative diffusion tensor imaging (Liu et al, 2008;Bora et al, 2010;Wang et al, 2011;Lin et al, 2012;Zhang et al, 2013).Numerous imaging studies have shown structural deficits that are associated both gray (Liu et al, 2009a;Yuan et al, 2009Yuan et al, , 2010bWang et al, 2012;Denier et al, 2013a;Qiu et al, 2013) and white matter (Liu et al, 2008;Bora et al, 2010;Wang et al, 2011;Lin et al, 2012;Li et al, 2013c;Zhang et al, 2013) reductions, perfusion's decrement (Denier et al, 2013a(Denier et al, , 2013b, diminished homogeneity and abnormal cortical thickness (Li et al, 2013a). Moreover, few studies associated structural reductions with rsFC impairments (Liu et al, 2009b;Yuan et al, 2009Yuan et al, , 2010aYuan et al, , 2010cMa et al, 2010) despite the fact that their causal relationship remains unknown.…”

mentioning

confidence: 99%

“…In other words, a network member observing the substance use by the other members has the tendency to mimic the friends' behavior (Reifman et al, 2006;Bohnert et al, 2009) Emotion recognition is essential to social readjustment and interaction (Blair, 2003;Fernández-Serrano et al, 2010). However, neural substrates that are responsible for emotion recognition are also involved in drug addiction(Verdejo-García and Bechara, 2009)and thus they were found to be impaired (Rosselli and Ardila, 1996;Reay et al, 2006;Homer et al, 2008).To the best of our knoweledge, the relationship between heroin addiction and emotion recognition has not been studied, but a lot of work has been conducted on other illicit drugs such as prefrontal GM volumeatrophy and frontal WM deficits might be a biomarker for behavioral and neuropsychological deregulations underlying heroin addiction (Lyoo et al, 2006;Li et al, 2013c;Zhang et al, 2013). However, the reversibility in GM alterations might provide an explanation for the recovery of several cognitive skills andanxiety .…”

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Resting-state Abnormalities in Heroin-dependent Individuals

Pandria

Kovatsi

Vivas³

et al. 2018

Neuroscience

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Article available under the terms of the CC-BY-NC-ND licence (https://creativecommons.org/licenses/by-nc-nd/4.0/) eprints@whiterose.ac.uk https://eprints.whiterose.ac.uk/ Reuse Unless indicated otherwise, fulltext items are protected by copyright with all rights reserved. The copyright exception in section 29 of the Copyright, Designs and Patents Act 1988 allows the making of a single copy solely for the purpose of non-commercial research or private study within the limits of fair dealing. The publisher or other rights-holder may allow further reproduction and re-use of this version -refer to the White Rose Research Online record for this item. Where records identify the publisher as the copyright holder, users can verify any specific terms of use on the publisher's website. TakedownIf you consider content in White Rose Research Online to be in breach of UK law, please notify us by emailing eprints@whiterose.ac.uk including the URL of the record and the reason for the withdrawal request. AbstractDrug addiction is a major health problem worldwide. Recent neuroimaging studies have shed light into the underlying mechanisms of drug addiction as well as its consequences to the human brain. The most vulnerable, to heroin addiction, brain regions have been reported to be specific regions in the prefrontal, parietal, occipital, and temporal lobes, as well as, some subcortical regions.The brain regions involvedare linked with reward, motivation/drive, memory/learning, inhibition as well as emotional control andseem to form circuitsthat interact with each other. So, along with neuroimaging studies, recent advances in resting-state dynamics might allow further assessments upon the multilayer complexity of addiction. In the current manuscript, we comprehensively reviewand discuss all the existing resting-state neuroimaging findings classified into three overlapping and interconnected groups: functional connectivity alterations, structural deficits and abnormal topological properties. Moreover, behavioral traits of heroin-addicted individuals as well as the limitations of the currently available studies are also reviewed. Finally, in need of a contemporary therapya multimodal therapeutic approach is suggested using classical treatment practices along with current neurotechonologies, such as neurofeedback and goal-oriented video-games Keywords:Heroin addiction, resting-state, functional and structural connectivity, small-world properties, behavioral traits of heroin-dependent individuals. Radial Diffusivity (RD) 5 Drug addiction or substance dependence (Koob and Le Moal, 2005)is defined as a multifaceted neuropsychiatric disorder resulting from complex interactions between neurobiological, environmental, genetic and pharmacological variables (Sutherland et al., 2012).It affects both cognitive as well as emotional processes . Furthermore, the compulsive seeking and taking of the drug despite the negative consequences, (including downward social mobility (Denier et al., 2013b)), constitutes its behavioral phenotype (Volkow ...

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Section: Resting-state Structural Deficits In Heroin Dependent Indivimentioning

confidence: 99%

Section: Resting-state Structural Deficits In Heroin Dependent Indivimentioning

confidence: 99%

Section: [Figure 1]mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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Resting-state Abnormalities in Heroin-dependent Individuals

Pandria

Kovatsi

Vivas³

et al. 2018

Neuroscience

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Association between the catechol‐O‐methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population

Shibata

Nagata

Tagai

et al. 2014

Int J Geriat Psychiatry

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COMT genotype affects brain white matter pathways in attention-deficit/hyperactivity disorder

et al. 2014

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Increased dopamine availability may be associated with impaired structural maturation of brain white matter connectivity. This study aimed to derive a comprehensive, whole-brain characterization of large-scale axonal connectivity differences in attention-deficit/hyperactivity disorder (ADHD) associated with catechol-O-methyltransferase gene (COMT) Val158Met polymorphism. Using diffusion tensor imaging, whole-brain tractography, and an imaging connectomics approach, we characterized altered white matter connectivity in youth with ADHD who were COMT Val-homozygous (N = 29) compared with those who were Met-carriers (N = 29). Additionally, we examined whether dopamine transporter gene (DAT1) and dopamine D4 receptor gene (DRD4) polymorphisms were associated with white matter differences. Level of attention was assessed using the continuous performance test before and after an 8-week open-label trial of methylphenidate (MPH). A network of white matter connections linking 18 different brain regions was significantly weakened in youth with ADHD who were COMT Met-carriers compared to those who were Val-homozygous (P < 0.05, family-wise error-corrected). A measure of white matter integrity, fractional anisotropy, was correlated with impaired pretreatment performance in continuous performance test omission errors and response time variability, as well as with improvement in continuous performance test response time variability after MPH treatment. Altered white matter connectivity was exclusively based on COMT genotypes, and was not evident in DAT1 or DRD4. We demonstrated that white matter connectivity in youth with ADHD is associated with COMT Val158Met genotypes. The present findings suggest that different layers of dopamine-related genes and interindividual variability in the genetic polymorphisms should be taken into account when investigating the human connectome.

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Prefrontal white matter impairment in substance users depends upon the catechol-o-methyl transferase (COMT) val158met polymorphism

Cited by 21 publications

References 59 publications

Resting-state Abnormalities in Heroin-dependent Individuals

Resting-state Abnormalities in Heroin-dependent Individuals

Association between the catechol‐O‐methyltransferase polymorphism Val158Met and Alzheimer's disease in a Japanese population

COMT genotype affects brain white matter pathways in attention-deficit/hyperactivity disorder

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