Early-stage cervical cancer: Tumor delineation by magnetic resonance imaging and ultrasound — A European multicenter trial

Epstein, Elisabeth; Testa, Antonia Carla; Gaurilčikas, Adrius; Legge, A. Di; Ameye, Lieveke; Atstupėnaitė, Vaida; Valentini, Anna Lia; Gui, Benedetta; Wallengren, Nils-Olof; Pudaric, Sonja; Čižauskas, Arvydas; Måsbäck, Anna; Zannoni, Gian Franco; Kannisto, Päivi; Zikán, Michal; Pinkavova, I.; Burgetová, Andrea; Dundr, Pavel; Němejcová, Kristýna; Cibula, David; Fischerová, D.

doi:10.1016/j.ygyno.2012.09.025

Cited by 126 publications

(140 citation statements)

References 20 publications

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“…Similar results were obtained in a study that compared the benefits of hybrid MRI/PET and PET/CT with proven sensitivity of 54.2 % for MRI/PET and 44.1 % for PET/CT [28]. The specificity of both imaging methods (MRI and PET/ [24] Sens sensitivity, Spec specificity, CI confidence interval CT) was high (92.6 %) [27] and comparable to ultrasound (96 %) [25,26].…”

Section: Preoperative Assessment Of Infiltrated (Metastatic) Lymph Nodessupporting

confidence: 78%

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Ultrasound in Gynecological Cancer: Is It Time for Re-evaluation of Its Uses?

Fischerová

Cibula

2015

Curr Oncol Rep

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Ultrasound is the primary imaging modality in gynecological oncology. Over the last decade, there has been a massive technology development which led to a dramatic improvement in the quality ultrasound imaging. If performed by an experienced sonographer, ultrasound has an invaluable role in the primary diagnosis of gynecological cancer, in the assessment of tumor extent in the pelvis and abdominal cavity, in the evaluation of the treatment response, and in follow-up. Ultrasound is also a valuable procedure for monitoring patients treated with fertility-sparing surgery. Furthermore, it is an ideal technique to guide tru-cut biopsy for the collection of material for histology. Taking into consideration that besides its accuracy, the ultrasound is a commonly available, non-invasive, and inexpensive imaging method that can be carried out without any risk or discomfort to the patient; it is time to reconsider its role in gynecologic oncology and to allocate resources for a specialized education of future experts in ultrasound imaging in gynecology.

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Section: Preoperative Assessment Of Infiltrated (Metastatic) Lymph Nodessupporting

confidence: 78%

“…A European multicenter trial initiated by Epstein et al ran from 2007 to 2010 and consequently included 182 patients with histologically confirmed early-stage cancer [24]. Results of a study published in 2013 are presented in Table 2.…”

Section: Local Staging In Patients With Early-stage Diseasementioning

confidence: 99%

Ultrasound in Gynecological Cancer: Is It Time for Re-evaluation of Its Uses?

Fischerová

Cibula

2015

Curr Oncol Rep

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“…These results showed that TVS was superior to MRI in both women with and without cone biopsy prior to surgery [11].…”

Section: Transvaginal/transrectal Ultrasound For Local Staging Of Cermentioning

confidence: 77%

The Role of Ultrasound in the Assessment of Uterine Cervical Cancer

Alcázar

Arribas²,

Mínguez

et al. 2014

J Obstet Gynecol India

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Uterine cervical cancer is the second most frequent gynecological malignancy worldwide. The assessment of the extent of disease is essential for planning optimal treatment. Imaging techniques are increasingly used in the pre-treatment work-up of cervical cancer. Currently, MRI for local extent of disease evaluation and PET-scan for distant disease assessment are considered as first-line techniques. Notwithstanding, in the last few years, ultrasound has gained attention as an imaging technique for evaluating women with cervical cancer. In this paper, current knowledge about the use of ultrasound for assessing uterine cervical cancer will be reviewed and discussed.

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“…A thorough three-dimensional pathologic assessment demonstrated that subclinical or occult parametrial spreading of the so-called ‘early' tumors (stages IB-IIA) occurred in about 30-60% of these patients, and pelvic LNM was always associated with parametrial disease. Therefore, preoperative assessment, such as through ultrasound or magnetic resonance imaging (MRI) looking for the presence of DSI and/or PI, may be needed before definite radical surgery [21,22]. In addition, we have previously reported that the predictive factors associated with PI were DSI and tumor > 2 cm [6.…”

Section: Discussionmentioning

confidence: 99%

Predictive Factors of Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

Nanthamongkolkul

Hanprasertpong²

2018

Oncol Res Treat

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Background: Pelvic lymphadenectomy, which is the routine surgical treatment for early-stage cervical cancer, causes serious morbidity. The goal of the current retrospective study was to identify predictive factors of lymph node metastasis (LNM) in patients with early-stage cervical cancer. Patients and Methods: The study included 496 patients diagnosed with stages IA2-IB1cervical cancer who underwent a radical hysterectomy with pelvic lymphadenectomy. The predictive factors of LNM were evaluated. Results: The incidence of LNM in this study was 4.6%. LNM was more common in patients with deep stromal invasion (DSI), tumor size > 2 cm, lymph vascular invasion and parametrial involvement (PI). Multivariate analysis showed DSI (p = 0.010) and PI (p = 0.005) were independently associated with LNM. The median follow-up time was 56.9 months. The patients with LNM had poorer 5-year overall survival (77.8%; 95% confidence interval (CI) 44.2-92.6) than the patients without LNM (98.2%; 95% CI 95.6-99.2; p = 0.002) and also poorer 5-year recurrence-free survival (65.5%; 95% CI 38.6-82.8) than the patients without LNM (90.2%; 95% CI 86.5-92.9; p < 0.001). Conclusion: The predictive factors of pelvic lymph node metastasis in stage IA2-IB1 cervical cancer patients were DSI and PI. LNM was associated with poorer oncological outcomes.

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Early-stage cervical cancer: Tumor delineation by magnetic resonance imaging and ultrasound — A European multicenter trial

Cited by 126 publications

References 20 publications

Ultrasound in Gynecological Cancer: Is It Time for Re-evaluation of Its Uses?

Ultrasound in Gynecological Cancer: Is It Time for Re-evaluation of Its Uses?

The Role of Ultrasound in the Assessment of Uterine Cervical Cancer

Predictive Factors of Pelvic Lymph Node Metastasis in Early-Stage Cervical Cancer

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