22nd International Symposium on Shiftwork and Working Time: Challenges and solutions for healthy working hours

Honn, Kimberly; Garde, Anne Helene; Fischer, Frida Marina; Dongen, Hans P A Van

doi:10.1080/07420528.2016.1195632

Cited by 7 publications

(7 citation statements)

References 38 publications

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“…Shift work-related metabolic dysfunction and the various health consequences thereof, including obesity, metabolic syndrome, and type II diabetes (discussed above), also potentiate the development of CVD [88,89]. Adipokines (cell signaling proteins) secreted by fat tissue and involved in immune responses—and more generally the development of a compromised immune system due to circadian misalignment—may connect these different factors [90]. Further research into candidate mechanisms must consider not only circadian misalignment from shift work, but also socioeconomic indicators and occupational factors (e.g., physical/mental workload, workplace stressors) known to be associated with poor heart health [91].…”

Section: Heart Healthmentioning

confidence: 99%

Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being

James

Honn

Gaddameedhi

et al. 2017

Curr Sleep Medicine Rep

Self Cite

325

232

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Purpose of review Our 24/7 society is dependent on shift work, despite mounting evidence for negative health outcomes from sleep displacement due to shift work. This paper reviews short- and long-term health consequences of sleep displacement and circadian misalignment due to shift work. Recent findings We focus on four broad health domains: metabolic health; risk of cancer; cardiovascular health; and mental health. Circadian misalignment affects these domains by inducing sleep deficiency, sympathovagal and hormonal imbalance, inflammation, impaired glucose metabolism, and dysregulated cell cycles. This leads to a range of medical conditions, including obesity, metabolic syndrome, type II diabetes, gastrointestinal dysfunction, compromised immune function, cardiovascular disease, excessive sleepiness, mood and social disorders, and increased cancer risk. Summary Interactions of biological disturbances with behavioral and societal factors shape the effects of shift work on health and well-being. Research is needed to better understand the underlying mechanisms and drive the development of countermeasures.

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Section: Heart Healthmentioning

confidence: 99%

Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being

James

Honn

Gaddameedhi

et al. 2017

Curr Sleep Medicine Rep

Self Cite

325

232

View full text Add to dashboard Cite

show abstract

“…It is also well known that IL-1β and TNF-α are associated with sleep quality, which for shiftworkers is depressed because of the requirement to sleep during the daytime light phase, the biological time of greatest alertness for the human species (Dijk D-J 1999;Drake et al 2004). Therefore, shiftworkers are often chronically sleep deprived (Honn et al 2016;Smith et al 2009), giving rise to increased risk for diminished health and work accidents (Laugsand et al 2014).…”

Section: Sleep and Immunomodulatory Functionmentioning

confidence: 99%

Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?

Silva

Guerreiro

Andrade

et al. 2020

Chronobiology International

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Rotating and permanent night shiftwork schedules typically result in acute and sometimes chronic sleep deprivation plus acute and sometimes chronic disruption of the circadian time structure. Immune system processes and functionalities are organized as circadian rhythms, and they are also strongly influenced by sleep status. Sleep is a vital behavioral state of living beings and a modulator of immune function and responsiveness. Shiftworkers show increased risk for developing viral infections due to possible compromise of both innate and acquired immunity responses. Short sleep and sleep loss, common consequences of shiftwork, are associated with altered integrity of the immune system. We discuss the possible excess risk for COVID-19 infection in the context of the common conditions among shiftworkers, including nurses, doctors, and first responders, among others of high exposure to the contagion, of sleep imbalance and circadian disruption.

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“…Shift work has substantial negative effects on long-term health1 ) . Shift work is associated with hypertension, myocardial infarction, diabetes, and obesity2 ) .…”

Section: Introductionmentioning

confidence: 99%

Cardiac autonomic activity during simulated shift work

et al. 2019

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Shift work leads to adverse health outcomes including increased risk of cardiovascular disease. Heart rate (HR) and heart rate variability (HRV) are measures of cardiac autonomic activity and markers of cardiovascular disease and mortality. To investigate the effects of shift work on cardiac autonomic activity, we assessed the influence of simulated night work on HR and HRV, and dissociated the direct effects of circadian misalignment from those of sleep displacement and altered physical activity patterns. A total of 29 subjects each participated in one of two in-laboratory, simulated shift work studies. In both studies, EKG was continuously monitored via Holter monitors to measure HR and the high frequency (HF) component of HRV (HF-HRV). We found endogenous circadian rhythmicity in HR and HF-HRV. Sleep and waking physical activity, both displaced during simulated night work, had more substantial, and opposite, effects on HR and HF-HRV. Our findings show systematic but complex, interacting effects of time of day, sleep/wake state, and physical activity on cardiac autonomic activity. These effects need to be taken into account when evaluating HR and HRV in shift work settings and when interpreting these measures of cardiac autonomic activity as markers of cardiovascular disease.

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22nd International Symposium on Shiftwork and Working Time: Challenges and solutions for healthy working hours

Cited by 7 publications

References 38 publications

Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being

Shift Work: Disrupted Circadian Rhythms and Sleep—Implications for Health and Well-being

Does the compromised sleep and circadian disruption of night and shiftworkers make them highly vulnerable to 2019 coronavirus disease (COVID-19)?

Cardiac autonomic activity during simulated shift work

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