Ultrasonic irradiation assisted surface modification of titanium plates to improve MC3T3-E1 cell proliferation

Abstract

The surface modification of titanium implants by NaOH has been widely investigated to improve their biocompatibility and bioactivity. It is very important to prepare an even network structure on titanium implants. In this work, ultrasonic irradiation (UI) is used along two different routes to obtain several modified surfaces on titanium plates: (1) the plates are first treated by a NaOH solution, and then UI is used to wash them in double distilled water; (2) the plates are modified by a NaOH solution in an ultrasonic cleaner with UI at 50 W. It is demonstrated that the UI energy can easily remove any weakly bound layers (WBL) on the titanium surface, leaving a strongly bound layer (SBL). The SBL is shown to enhance the proliferation of MC3T3-E1 preosteoblasts in comparison with the WBL. A dense and uniformly distributed nanostructure layer can be synthesized in situ on the surface of metallic titanium through a reaction between a NaOH solution and titanium under UI. The titanium plates prepared with NaOH and UI show better proliferation of preosteoblasts than titanium without UI.

Rapamycin/sodium hyaluronate binding on nano-hydroxyapatite coated titanium surface improves MC3T3-E1 osteogenesis

“…In previous study, our group modified topography of Ti surface to achieve bioactive Ti for dental implant, bone screws and plates [ 33 ]. Our result proves that both micro- and nano-topographies improve cell functions on osteogenesis.…”

The biofilm removal effect and osteogenic potential on the titanium surface by electrolytic cleaning: An in vitro comparison of electrolytic parameters and five techniques

“…Therefore, we speculated that the improved osteogenic potential for electrolytic cleaning‐treated Ti might also be related to the alkaline environment generated by electrolysis. Because the surface modification of Ti implants by NaOH has been widely investigated to improve their biocompatibility and bioactivity (Tan et al., 2013). Alkaline treatment has also been a preclinical treatment to improve the success rate of implants (Tugulu et al., 2010).…”

Surface modified titania nanotubes containing anti-bacterial drugs for controlled delivery nanosystems with high bioactivity

“…Surface functionalization of nanomaterials is realized to be vital, by which TNTs are endowed with advanced surfaces and could contribute to a wide range of biomedical applications. 9 Moreover, surface functionalizations, such as chemical modi-cation 10 and composite coating, 11 can overcome the bioinert nature of TNTs, increased interaction with tissues 12 and fortify adhesion to cells, 13 by which obstacles such as charge or size effects of drug molecules to move through the cell membranes could be handled. Furthermore, selected surface graed molecules can increase the electrostatic and hydrogen bonding effect of nanotubes towards drug molecules.…”