Surface modified titania nanotubes containing anti-bacterial drugs for controlled delivery nanosystems with high bioactivity

Huang, Peilin; Wang, Jingnan; Lai, Shuting; Liu, Fang; Ni, Nan; Cao, Qingqing; Liu, Wei; Deng, David Y.B.; Zhou, Wuyi

doi:10.1039/c4tb01281j

Cited by 32 publications

(18 citation statements)

References 39 publications

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“…In most cases, nanocrystalline titanium dioxide can be synthesized by wet or dry processes. In last years, a variety of methods, such as sol-gel [57,58], hydrothermal/solvothermal methods [59,60], or methods based on electrochemical anodization [61–63] have been developed to control the size, morphology, and porosity and of the resulting TiO 2 nanostructures. DDS methods have been developed primarily for the anthracycline cytostatic doxorubicin, which is one of the most commonly used cytostatics.…”

Section: Resultsmentioning

confidence: 99%

Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents

Šťastný¹,

Štengl²,

Štenglová-Netíková³

et al. 2019

PLoS ONE

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Anthracyclines are a class of pharmaceuticals used in cancer treatment have the potential to negatively impact the environment. To study the possibilities of anthracyclines (represented by pirarubicin and valrubicin) removal, chemical inactivation using NaOH (0.01 M) and NaClO (5%) as decontamination agents and adsorption to powdered nanocrystalline titanium dioxide (TiO2) were compared. The titanium dioxide (TiO2) nanoparticles were prepared via homogeneous precipitation of an aqueous solution of titanium (IV) oxy-sulfate (TiOSO4) at different amount (5–120 g) with urea. The as-prepared TiO2 samples were characterized by XRD, HRSEM and nitrogen physisorption. The adsorption process of anthracycline cytostatics was determined followed by high-performance liquid chromatography coupled with mass spectrometry (LC-MS) and an in-situ Diffuse Reflectance Infrared Fourier Transform Spectroscopy (DRIFTS) technique. It was found that NaClO decomposes anthracyclines to form various transformation products (TPs). No TPs were identified after the reaction of valrubicin with a NaOH solution as well as in the presence of TiO2 nanoparticles. The best degree of removal, 100% of pirarubicin and 85% of valrubicin, has been achieved in a sample with 120 grams of TiOSO4 (TIT120) and TiO2 with 60 grams (TIT60), respectively.

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Section: Resultsmentioning

confidence: 99%

Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents

Šťastný¹,

Štengl²,

Štenglová-Netíková³

et al. 2019

PLoS ONE

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“…Cytotoxicity at certain particle sizes and/or concentrations Oh et al, 2005;Raja et al, 2005;Magrez et al, 2009;Lai et al, 2011;Lallana et al, 2012;Portan et al, 2012;Tang et al, 2012;Setyawati et al, 2013;Shadjou and Hasanzadeh, 2015;Zhou et al, 2015;Cui et al, 2018;Tang et al, 2014;Hu et al, 2012;Huang et al, 2014;Kwon et al, 2017;Liu et al, 2017 Organic nanostructured delivery systems Alcantar et al, 2000;Habraken et al, 2007;Lü et al, 2009;Puppi et al, 2010;Anderson and Shive, 2012;Makadia and Siegel, 2011;Jacob et al, 2018 Natural polymers (e.g., gelatin, chitosan)…”

Section: Mimicking Bone's Biochemical Niche: Delivery Of Bioactive Momentioning

confidence: 99%

“…TiO 2 nanotubes for delivery of drugs and other biomolecules have also been described (Hu et al, 2012;Huang et al, 2014;Kwon et al, 2017). These can be designed to both encapsulate and display the molecule of interest on the material surface (Huang et al, 2014). One group directly functionalized the surface of TiO 2 nanotubes with BMP-2, which promoted osteogenic differentiation in vitro (Lai et al, 2011).…”

Section: Inorganic Nanostructured Delivery Systemsmentioning

confidence: 99%

Nanostructured Biomaterials for Bone Regeneration

Lyons

Plantz

Hsu

et al. 2020

Front. Bioeng. Biotechnol.

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This review article addresses the various aspects of nano-biomaterials used in or being pursued for the purpose of promoting bone regeneration. In the last decade, significant growth in the fields of polymer sciences, nanotechnology, and biotechnology has resulted in the development of new nano-biomaterials. These are extensively explored as drug delivery carriers and as implantable devices. At the interface of nanomaterials and biological systems, the organic and synthetic worlds have merged over the past two decades, forming a new scientific field incorporating nano-material design for biological applications. For this field to evolve, there is a need to understand the dynamic forces and molecular components that shape these interactions and influence function, while also considering safety. While there is still much to learn about the bio-physicochemical interactions at the interface, we are at a point where pockets of accumulated knowledge can provide a conceptual framework to guide further exploration and inform future product development. This review is intended as a resource for academics, scientists, and physicians working in the field of orthopedics and bone repair.

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“…Huang et al demonstrated that novel drug delivery nanosystems, such as enrofloxacin (Enro)‐NH 2 ‐TNTs and enrofloxacin‐SH‐TNTs, were successfully synthesized through vacuum processing and a pH adjusted method using NH 2 ‐TNTs and SH‐TNTs as drug delivery materials . Through XRD, IR, BET and TEM analyses, Enro molecules were found to interact with modified TNTs through ionic bonds or hydrogen bonds.…”

Section: Applications Of Various Nanomaterials In Controlled Drug Delmentioning

confidence: 99%

The application of nanomaterials in controlled drug delivery for bone regeneration

Shi

Jiang

Zhao

et al. 2015

J Biomedical Materials Res

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Bone regeneration is a complicated process that involves a series of biological events, such as cellular recruitment, proliferation and differentiation, and so forth, which have been found to be significantly affected by controlled drug delivery. Recently, a lot of research studies have been launched on the application of nanomaterials in controlled drug delivery for bone regeneration. In this article, the latest research progress in this area regarding the use of bioceramics-based, polymer-based, metallic oxide-based and other types of nanomaterials in controlled drug delivery for bone regeneration are reviewed and discussed, which indicates that the controlling drug delivery with nanomaterials should be a very promising treatment in orthopedics. Furthermore, some new challenges about the future research on the application of nanomaterials in controlled drug delivery for bone regeneration are described in the conclusion and perspectives part. V C 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3978-3992, 2015.

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Surface modified titania nanotubes containing anti-bacterial drugs for controlled delivery nanosystems with high bioactivity

Abstract: Drug delivery nanosystems have been designed as Enro-NH2-TNTs and Enro-SH-TNTs with high bioactivity and excellent in vitro and in vivo controlled release.

Cited by 32 publications

References 39 publications

Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents

Removal of anthracycline cytostatics from aquatic environment: Comparison of nanocrystalline titanium dioxide and decontamination agents

Nanostructured Biomaterials for Bone Regeneration

The application of nanomaterials in controlled drug delivery for bone regeneration

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