221: MPGN and Nephrotic Syndrome (NS) Secondary to Lyme Disease (LD)

Rawal, Bishal; Rovner, Leon; Thakar, Charuhas V.; Pollock, J

doi:10.1053/j.ajkd.2008.02.231

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…To our knowledge, the case presented here is the first description of C1q-positive ‘full-house’ pattern MPGN in association with active Lyme disease. Rawal et al reported acute renal failure, nephrotic syndrome and hypocomplementaemia in a patient who had been diagnosed with Lyme disease 12 years earlier [8]. However, the immunohistological pattern was not described and the result of testing for cryoglobulins was inconclusive.…”

Section: Discussionmentioning

confidence: 99%

Borrelia and nephropathy: cryoglobulinaemic membranoproliferative glomerulonephritis responsive to doxycyclin in active Lyme disease

et al. 2012

View full text Add to dashboard Cite

The association of membranoproliferative glomerulonephritis (MPGN) with Lyme borreliosis has only been reported for the C1q-negative subtype. A 64-year-old male presenting with rising creatinine, nephrotic syndrome and monoarthritis few months after a tick bite was noted to have mixed cryoglobulinaemia, a positive borrelia western blot and ‘full-house’ pattern MPGN with interstitial granuloma. Findings resolved with prednisolone and doxycyclin therapy. The histology is consistent with MPGN secondary to cryoglobulinaemia, which has most likely been caused by borrelia infection. ‘Full-house’ pattern MPGN may result from Lyme borreliosis through cryoglobulinaemia and may be treated successfully with the appropriate antibiotic therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Borrelia and nephropathy: cryoglobulinaemic membranoproliferative glomerulonephritis responsive to doxycyclin in active Lyme disease

et al. 2012

View full text Add to dashboard Cite

show abstract

“…[20]. При проведении настоящего исследования нами было обнаружено описание 9 случаев нарушений функции почек, достоверно связанных с боррелиозом [20][21][22][23][24][25][26][27][28]. Поражение почек при болезни Лайма являются следствием воспалительной реакции после контакта с Borrelia burgdorferi.…”

Section: результаты и обсуждениеunclassified

Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease

Velts¹,

Журавлева²,

Кутехова³

et al. 2022

Bezopasnost' i risk farmakoterapii

View full text Add to dashboard Cite

Adverse drug reactions (ADRs) are recorded throughout the lifecycle of a medicinal product. In the post-marketing period, new ADRs are primarily identified via drug safety signals. In order to assess a signal and establish causality between an adverse drug reaction and a suspected medicinal product, it is necessary to evaluate the signal strength and quality.The aim of the study was to analyse the information submitted to Russian regulatory authorities by a patient and check it for a potential causal association of acute tubulointerstitial nephritis (ATIN) with the use of ceftriaxone and with the patient’s principal diagnosis, Lyme disease.Materials and methods: the authors analysed the patient’s submission received by the Ministry of Health of the Russian Federation in 2022 with a complaint that the treatment of Lyme disease with ceftriaxone had caused ATIN. The probability of a causal relationship between the medicinal product and the ADR was evaluated using the Naranjo algorithm.Results: according to the review of literature and the spontaneous reports collected in Pharmacovigilance 2.0, the database in the Automated Information System of the Russian Federal Service for Surveillance in Healthcare, both ceftriaxone and the underlying condition (Lyme disease) may cause renal abnormalities. Ceftriaxone is potentially nephrotoxic; it mainly affects the tubular system of the kidneys. Borreliosis may cause kidney damage as well; such damage manifests clinically as rapidly progressing and fatal damage to the glomeruli.Conclusions: the probability of a causal relationship between the development of ATIN in the complainant and the use of ceftriaxone was categorised as “possible”. However, the information available did not allow for establishing a definite relationship between kidney damage and the use of the medicinal product. Further monitoring of similar cases is necessary to minimise the risks of developing this pathology during treatment with ceftriaxone.

show abstract

La néphrite de Lyme chez l’homme : bases physiopathologiques et spectre lésionnel rénal

Gueye

Seck

Kane

et al. 2019

Néphrologie & Thérapeutique

View full text Add to dashboard Cite

221: MPGN and Nephrotic Syndrome (NS) Secondary to Lyme Disease (LD)

Cited by 3 publications

References 0 publications

Borrelia and nephropathy: cryoglobulinaemic membranoproliferative glomerulonephritis responsive to doxycyclin in active Lyme disease

Borrelia and nephropathy: cryoglobulinaemic membranoproliferative glomerulonephritis responsive to doxycyclin in active Lyme disease

Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease

La néphrite de Lyme chez l’homme : bases physiopathologiques et spectre lésionnel rénal

Contact Info

Product

Resources

About