La néphrite de Lyme chez l’homme : bases physiopathologiques et spectre lésionnel rénal

Gueye, Serigne; Seck, Sidy Mouhamed; Kane, Yaya; Tosi, Pierre-Olivier; Dahri, S.; Kounde, Clément; Algouzmari, Ilham; Gouin, Anna; Ged, E.; Allal, Asma; Rostaing, Lionel

doi:10.1016/j.nephro.2018.09.004

Cited by 3 publications

(3 citation statements)

References 46 publications

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“…Гуйе и соавт. указывают, что нефропатия, ассоциированная с отложениями ЦИК, является наиболее часто встречающейся гистологической формой болезни Лайма [29]. Данный механизм нарушения функции почек был идентифицирован в 6 из 9 обнаруженных в литературных источниках описаний случаев развития нефрита Лайма: диагностировано три случая мембранопролиферативного гломерулонефрита I типа (один из них связан с криоглобулинемией II типа), один случай экстрамембранозного и два случая эндокапиллярного гломерулонефрита.…”

Section: результаты и обсуждениеunclassified

Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease

Velts¹,

Журавлева²,

Кутехова³

et al. 2022

Bezopasnost' i risk farmakoterapii

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Adverse drug reactions (ADRs) are recorded throughout the lifecycle of a medicinal product. In the post-marketing period, new ADRs are primarily identified via drug safety signals. In order to assess a signal and establish causality between an adverse drug reaction and a suspected medicinal product, it is necessary to evaluate the signal strength and quality.The aim of the study was to analyse the information submitted to Russian regulatory authorities by a patient and check it for a potential causal association of acute tubulointerstitial nephritis (ATIN) with the use of ceftriaxone and with the patient’s principal diagnosis, Lyme disease.Materials and methods: the authors analysed the patient’s submission received by the Ministry of Health of the Russian Federation in 2022 with a complaint that the treatment of Lyme disease with ceftriaxone had caused ATIN. The probability of a causal relationship between the medicinal product and the ADR was evaluated using the Naranjo algorithm.Results: according to the review of literature and the spontaneous reports collected in Pharmacovigilance 2.0, the database in the Automated Information System of the Russian Federal Service for Surveillance in Healthcare, both ceftriaxone and the underlying condition (Lyme disease) may cause renal abnormalities. Ceftriaxone is potentially nephrotoxic; it mainly affects the tubular system of the kidneys. Borreliosis may cause kidney damage as well; such damage manifests clinically as rapidly progressing and fatal damage to the glomeruli.Conclusions: the probability of a causal relationship between the development of ATIN in the complainant and the use of ceftriaxone was categorised as “possible”. However, the information available did not allow for establishing a definite relationship between kidney damage and the use of the medicinal product. Further monitoring of similar cases is necessary to minimise the risks of developing this pathology during treatment with ceftriaxone.

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Section: результаты и обсуждениеunclassified

Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease

Velts¹,

Журавлева²,

Кутехова³

et al. 2022

Bezopasnost' i risk farmakoterapii

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“…Lyme IgG and IgM were sent to investigate Lyme nephritis and were not detected, as Lyme disease has been reported to cause a diverse spectrum of glomerular disease. 10 – 15 …”

Section: Case Presentationmentioning

confidence: 99%

“…Lyme IgG and IgM were sent to investigate Lyme nephritis and were not detected, as Lyme disease has been reported to cause a diverse spectrum of glomerular disease. [10][11][12][13][14][15] Given the concern for a potential drug-induced MN, lack of serologic evidence for a primary form, and its low-grade chronic nature, immunosuppressants such as cyclophosphamide or rituximab were not pursued. The patient was further diuresed with metolazone 5 mg and furosemide 80 mg IV (intravenous) twice a day with improvements to his urine output and edema.…”

Section: Case Presentationmentioning

confidence: 99%

Ibuprofen-associated minimal change disease and acute interstitial nephritis with possibly linked membranous glomerulonephritis

Liu

Chang

Zuckerman

et al. 2021

SAGE Open Medical Case Reports

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Non-steroidal anti-inflammatory drugs are not only potent analgesics and antipyretics but also nephrotoxins, and may cause electrolyte disarray. In addition to the commonly expected effects, including hyperkalemia, hyponatremia, acute renal injury, renal cortical necrosis, and volume retention, glomerular disease with or without nephrotic syndrome or nephritis can occur as well including after years of seemingly safe administration. Minimal change disease, secondary membranous glomerulonephritis, and acute interstitial nephritis are all reported glomerular lesions seen with non-steroidal anti-inflammatory use. We report a patient who used non-steroidal anti-inflammatory drugs for years without diabetes, chronic kidney disease, or proteinuria; he then developed severe nephrotic range proteinuria with 7 g of daily urinary protein excretion. Renal biopsy showed minimal change nephropathy, a likely secondary membranous glomerulonephritis, and acute interstitial nephritis present simultaneously in one biopsy. Cessation of non-steroidal anti-inflammatory drug use along with steroid treatment resulted in a moderate improvement in renal function, though residual impairment remained. Urine heavy metal screen returned with elevated levels of urine copper, but with normal ceruloplasmin level. Workup suggested that the elevated copper levels were due to cirrhosis from non-alcoholic fatty liver disease. The membranous glomerulonephritis is possibly linked to non-steroidal anti-inflammatory drug exposure, and possibly to heavy metal exposure, and is clinically and pathologically much less likely to be a primary membranous glomerulonephritis with negative serological markers.

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Infectious Agents in Feline Chronic Kidney Disease

Hartmann¹,

Pennisi

Dorsch³

2020

Advances in Small Animal Care

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La néphrite de Lyme chez l’homme : bases physiopathologiques et spectre lésionnel rénal

Cited by 3 publications

References 46 publications

Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease

Analysis of the Causes for Renal Dysfunction during Antibiotic Therapy in a Patient with Lyme Disease

Ibuprofen-associated minimal change disease and acute interstitial nephritis with possibly linked membranous glomerulonephritis

Infectious Agents in Feline Chronic Kidney Disease

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