Flaxseed dietary fibers suppress postprandial lipemia and appetite sensation in young men

Kristensen, Mette; Savorani, Francesco; Christensen, S.; Engelsen, Søren B.; Bügel, Susanne; Toubro, Søren; Tetens, Inge; Astrup, Arne

doi:10.1016/j.numecd.2011.03.004

Cited by 68 publications

(60 citation statements)

References 25 publications

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“…These results are in concordance with those reported by Brant et al (2012), who found flaxseed to prevent excess of body weight gain in pregnant rats because of its beneficial effects on lipids and glucose profiles. This same observation had also been made by Daleprane et al (2010) in weaned rats, for the reason that flaxseed fibres and long-chain N-3 polyunsaturated fatty acid content could reduce both appetite sensation and energy intake (Kristensen et al, 2013). According to Bielanski and Kowalska (2008), the addition of linseed oil to rabbit diets has a favourable effect on the composition of the lipid fraction of its meat, with a significant decrease in total saturated fatty acids and cholesterol, as well as an increase in polyunsaturated fatty acids contents.…”

Section: Body Weight and Clinical Observationssupporting

confidence: 70%

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Beroual¹,

Almasi‐Hashiani²,

Bachtarzi³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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Background: The therapeutic safety of herbal medicine is a major concern for consumers and users. After studying the effects of linseed on hair growth in rabbits, the turn is to evaluate its safety by the observation of some clinical, biological and anatomo-pathological aspects. Materials and Methods: A study was conducted during a period of three months on two groups of rabbits (control and test). Test group daily received feed supplemented with 3g of ground linseed while the control animals received the same feed without any additives. Weekly, rabbits were weighed and monthly blood samples were taken. By the end of the trial, liver and kidneys biopsies were analyzed for histological and cytological lesions. Results: There was no significant improvement in weight gain in the test group rabbits, in which biochemical parameters had differentially evolved with a decrease in their Glycemia and cholesterolemia. There were also no modifications in their serum hepatic and renal marker enzymes and their liver and kidneys exhibited noticeably normal histology without any anatomically detectable anomalies. Conclusion: These findings confirm that prolonged linseed ingestion in rabbits is safe.

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Section: Body Weight and Clinical Observationssupporting

confidence: 70%

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Beroual¹,

Almasi‐Hashiani²,

Bachtarzi³

et al. 2016

Afr. J. Trad. Compl. Alt. Med.

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“…In line with this, we previously found that addition of whole linseed to rye breads (18 g/day) significantly reduced the digestibility of fat and energy in humans [13]. It was also found that a linseed DF extract incorporated into breads decreased not only hunger, but also postprandial triacylglycerol supporting that linseed DF decrease lipid absorption [14]. However, we also found that food matrix may affect the magnitude of effect, as linseed DF in drinks were more effective than when incorporated into breads in increasing faecal fat excretion [15].…”

Section: Introductionmentioning

confidence: 53%

“…The macronutrient composition of all six diets was the same, with ~110 g protein/kg DM, but they differed in DF content and source (Table 1). The DF were extracted from linseed hulls (provided by Natunola Health Inc., Ontario, Canada) as described elsewhere [14]. DF content of the linseed DF extract was measured according to the AOAC (No.…”

Section: Methodsmentioning

confidence: 99%

Linseed Dietary Fibers Reduce Apparent Digestibility of Energy and Fat and Weight Gain in Growing Rats

et al. 2013

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Dietary fibers (DF) may affect energy balance, an effect often ascribed to the viscous nature of some water soluble DF, which affect luminal viscosity and thus multiple physiological processes. We have tested the hypothesis that viscous linseed DF reduce apparent nutrient digestibility, and limit weight gain, in a randomized feeding trial where 60 male, growing, Wistar rats, with an initial weight of ~200 g, were fed different diets (n = 10 per group): low DF control (C), 5% DF from cellulose (5-CEL), CEL + 5% DF from whole (5-WL) or ground linseed (5-GL), CEL + 5% DF from linseed DF extract (5-LDF), and CEL + 10% DF from linseed DF extract (10-LDF). Diets were provided ad libitum for 21 days. Feed intake and faecal output were measured during days 17–21. Faecal fat excretion increased with increasing DF content and was highest in the 10-LDF group. Apparent fat digestibility was highest with the C diet (94.9% ± 0.8%) and lowest (74.3% ± 0.6%) with the 10-LDF diet, and decreased in a non-linear manner with increasing DF (p < 0.001). Apparent fat digestibility also decreased with increased accessibility of DF (5-WL vs. 5-GL) and when the proportion of viscous DF increased (5-GL vs. 5-LDF). The 10-LDF resulted in a lower final body weight (258 ± 6.2 g) compared to C (282 ± 5.9 g), 5-CEL (281 ± 5.9 g), and 5-WL (285 ± 5.9 g) (p < 0.05). The 10-LDF diet reduced body fat compared to 5-CEL (p < 0.01). In conclusion, DF extracted from linseed reduced apparent energy and fat digestibility and resulted in restriction of body weight gain in growing rats.

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“…This was unexpected as we have previously observed that flax fibers significantly increases both satiety and fullness [19] and no studies on viscous dietary fibers indicate that they should induce hunger. However, we believe that the Control drink based on MCS may have caused bloating, which may have been mistaken for fullness.…”

Section: Discussionmentioning

confidence: 80%

Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type

et al. 2012

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BackgroundDietary fibers have been proposed to play a role in cardiovascular risk as well as body weight management. Flaxseeds are a good source of dietary fibers, and a large proportion of these are water-soluble viscous fibers.MethodHere, we examine the effect of flaxseed dietary fibers in different food matrices on blood lipids and fecal excretion of fat and energy in a double-blind randomized crossover study with 17 subjects. Three different 7-d diets were tested: a low-fiber control diet (Control), a diet with flaxseed fiber drink (3/day) (Flax drink), and a diet with flaxseed fiber bread (3/day) (Flax bread). Total fat and energy excretion was measured in feces, blood samples were collected before and after each period, and appetite sensation registered 3 times daily before main meals.ResultsCompared to control, Flax drink lowered fasting total-cholesterol and LDL-cholesterol by 12 and 15%, respectively, (p < 0.01), whereas Flax bread only produced a reduction of 7 and 9%, respectively (p < 0.05). Fecal fat and energy excretion increased by 50 and 23% with Flax drink consumption compared to control (p < 0.05), but only fecal fat excretion was increased with Flax bread compared to control (p < 0.05).ConclusionBoth Flax drink and Flax bread resulted in decreased plasma total and LDL-cholesterol and increased fat excretion, but the food matrix and/or processing may be of importance. Viscous flaxseed dietary fibers may be a useful tool for lowering blood cholesterol and potentially play a role in energy balance.Trial RegistrationClinicalTrials.gov: NCT00953004

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Flaxseed dietary fibers suppress postprandial lipemia and appetite sensation in young men

Cited by 68 publications

References 25 publications

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Safety assessment of <i>Linum usitatissimum</i> (Linn.) Ingestion in New Zealand rabbits

Linseed Dietary Fibers Reduce Apparent Digestibility of Energy and Fat and Weight Gain in Growing Rats

Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type

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