2067 Breast-conserving radiation therapy using combined electron and IMRT technique

Li, J.G.; Xing, L.; Williams, Sabrina; Boyer, Arthur L.

doi:10.1016/s0360-3016(99)90337-1

Cited by 2 publications

(3 citation statements)

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“…As a consequence, breast irradiation has been associated with a number of potential complications [5][6][7][8] , including radiation induced pneumonitis, cardiac toxicity, rib fracture, arm edema, severe breast or chest wall fibrosis, soft tissue or bone necrosis, and radiation induced secondary cancer. Intensity Modulated Radiation Therapy (IMRT) is a highly promising technology that can potentially overcome these problems [9][10][11][12][13][14] . However, there are several practical issues in the treatment planning, delivery and quality assurance (QA) processes, which add significant overhead as compared to the standard OTF and make it clinically less useful.…”

Section: Inrtodcuctionmentioning

confidence: 99%

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Multiple Aperture Radiation Therapy (MART) to Breast Cancer

Li¹

2005

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Public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. Send comments regarding this burden estimate or any other aspect of this collection of information, including suggestions for reducing this burden to Department of Defense, Washington Headquarters Services, Directorate for Information Operations and Reports (0704-0188), 1215 Jefferson Davis Highway, Suite 1204, Arlington, VA 22202-4302. Respondents should be aware that notwithstanding any other provision of law, no person shall be subject to any penalty for failing to comply with a collection of information if it does not display a currently valid OMB control number. PLEASE DO NOT RETURN YOUR FORM TO THE ABOVE ADDRESS. 5e. TASK NUMBER 5f. WORK UNIT NUMBER REPORT DATE 01-11-2005 REPORT TYPE Annual Summary DATES COVERED PERFORMING ORGANIZATION NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBERStanford University Stanford, CA 94305 SPONSORING / MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR'S ACRONYM(S) U.S. Army Medical Research and Materiel Command Fort Detrick, Maryland 21702-5012 SPONSOR/MONITOR'S REPORT NUMBER(S) DISTRIBUTION / AVAILABILITY STATEMENTApproved for Public Release; Distribution Unlimited SUPPLEMENTARY NOTESOriginal contains colored plates: ALL DTIC reproductions will be in black and white. ABSTRACTCompared with conventional methods for breast cancer RT such as opposed tangential fields (OTF), modern IMRT provides unprecedented potential to deliver 3D-dose distributions with superior tumor conformality and normal tissue spare. In practice, however, the current IMRT process deviates significantly from the conventional approach and requires considerable costs of the time and health care. The complexity of the treatment and deliver procedure make this technology problematic for the breast radiotherapy. We have carried out a systematic study on a new solution, which is a hybrid of the advantages of the IMRT and OTF, termed as multiple aperture radiotherapy (MART). The efficiency in dose shaping and simplicity in dose delivery make it a perfect choice for breast cancer treatment.A number of important milestones have been accomplished, which include (i) developed an efficient optimization method for MART inverse planning; (ii) implemented MART in a clinic environment for breast treatment; (iii) proposed a gated IMRT/MART based on the cutting-edge technology of 4D CT imaging; (iv) established a robust technique for low-dose 4D CT acquisition to reduce the risks of radiation-induced cancer. It is expected these tools will greatly facilitate the imaging, planning, delivery, and quality assurance of breast radiation treatment. Conventional radiotherapy for breast cancer utilizes two opposed tangential fields (OTF) with either uniform or wedged photon beams [1][2][3][4] , and often presents proble...

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Section: Inrtodcuctionmentioning

confidence: 99%

“…8 Its simplicity and yet accuracy make it a preferred tool for clinical applications. [9][10][11] In this model, a lattice of user-defined nodes is overlaid on the image. Each node contains a deformation vector, whose components are to be determined by the optimization procedure.…”

Section: Deformable Registration For Phase Imagesmentioning

confidence: 99%

Multiple Aperture Radiation Therapy (MART) to Breast Cancer

Li¹

2005

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“…This includes the use of matched electron and photon beams to reduce dose to the underlying structures [9], the combination of conventional electron field and intensity-modulated photon beams [10], the irradiation using fan-beam and cone-beam intensitymodulated radiation therapy (IMRT) fields [11][12][13][14]. Each of these methods has pros and cons.…”

Section: 1mentioning

confidence: 99%

Multiple Aperture Radiation Therapy (MART) for Breast Cancer

Shou¹

2004

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Public reporting burden for this collection of infonnation is estimated to average 1 hour per response, induding the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing this collection of information. I. INTRODUCTION This postdoctoral fellowship grant (DAMD17-03-1-0657, entitled "Multiple Aperture Radiation Therapy for Breast Cancer") was awarded to the principal investigator (PI) for the period of Nov. 1, 2003-Oct. 31, 2005. This is the annual report for the first funding period (Nov. 1, 2003 -Oct. 31, 2004. The goal of this project is to develop a novel technique, Multiple Aperture Radiation Therapy (MART), as a candidate modality for treating breast cancer. The specific aims of this work are: (a) To demonstrate that MART can lead to substantially improved dose distribution over the conventional method, without increasing the complexity of the radiation treatment; (b) To show that the superior dose distributions of MART can be realized efficiently and accurately. Under the generous support from the U.S. Army Medical Research and Materiel Command (AMRMC), the PI has gained a tremendous amount of knowledge on breast cancer and breast cancer management over the last year. The support has also made it possible for the P1 to contribute significantly to breast cancer research. A number of conference abstracts and a refereed paper has been resulted from the support. In this report, the past year's research activities of the PI are summarized.

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2067 Breast-conserving radiation therapy using combined electron and IMRT technique

Cited by 2 publications

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Multiple Aperture Radiation Therapy (MART) to Breast Cancer

Multiple Aperture Radiation Therapy (MART) to Breast Cancer

Multiple Aperture Radiation Therapy (MART) for Breast Cancer

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