2020 FDA TIDES (Peptides and Oligonucleotides) Harvest

Musaimi, Othman Al; Shaer, Danah Al; Alberício, Fernando; Torre, Beatriz G. de la

doi:10.3390/ph14020145

Cited by 59 publications

(60 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among them, 68 Ga-PSMA-11 has been approved by the American Food and Drug Administration. 21 Because several kinds of PSMA PET tracers are labeled with 18 F or 68 Ga, and each of them may have different biological characteristics (e.g., different physiological distribution and excretion pathways), the standardized evaluation of PROMISE 7 and PSMA-RADS 22 system were introduced to regulate the interpretation of PSMA PET imaging results. PSMA-RADS system is evaluated based on the location of the lesion and the level of PSMA uptake, and it is relatively subjective in judging the degree of PSMA uptake by lesions.…”

Section: Discussionmentioning

confidence: 99%

Comparison between ¹⁸F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer

et al. 2021

View full text Add to dashboard Cite

Background: We aimed to compare the diagnostic performance of 18 F-DCFPyL positron emission tomography (PET) and multiparameter magnetic resonance imaging (mp-MRI) in detecting transition zone (TZ) prostate cancer (PCa).Methods: This retrospective study included 20 patients who underwent 18 F-DCFPyL PET/MRI and 32 patients who underwent 18 F-DCFPyL PET/CT and MRI from January 2019 to June 2020. All patients had TZ lesions and underwent prostate biopsies. One senior (reader 1) and one junior (reader 2) nuclear medicine physician evaluated each TZ lesion independently, according to the molecular imaging prostate-specific membrane antigen scoring system and the Prostate Imaging Reporting and Data System version 2.1 (PI-RADS v2.1). The histologic diagnosis of prostate biopsy was used as the reference standard. The diagnostic performance of the two methods was compared in terms of inter-reader agreement and area under the receiver operating characteristic (AUC-ROC) curve.Results: Of the 52 patients, 43 had TZ PCa. For inter-reader agreement, the kappa value was 0.883 for 18 F-DCFPyL PET and 0.393 for mp-MRI. For PET, both readers had the same diagnostic sensitivity, specificity, and accuracy of 93.0%, 77.8%, and 90.4%, respectively. For mp-MRI, the diagnostic sensitivity, specificity, and accuracy was 67.4%, 33.3%, and 61.5% for reader 1, and 51.2%, 44.4%, and 51.9% for reader 2, respectively. PET outperformed mp-MRI for both readers with an AUC of 0.872 for PET versus 0.584 for mp-MRI, p = .0209 for reader 1, and an AUC of 0.860 for PET versus 0.505 for mp-MRI, p = .0213 for reader 2. Among the 43 patients with TZ PCa, 18 F-DCFPyL PET detected a distant bone metastasis missed by the CT in one case and two small lymph node metastases missed by the CT and MRI in another case.Conclusions: These results suggest that 18 F-DCFPyL PET, which was almost independent of the experience of the readers, was more objective in the evaluation of TZ lesions, and had higher diagnostic value than mp-MRI.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparison between ¹⁸F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer

et al. 2021

View full text Add to dashboard Cite

show abstract

“…As peptides account for a substantial proportion of FDAapproved drugs (Al Musaimi et al, 2021), numerous peptide epitopes could potentially be incorporated into lasso peptides to develop new therapeutics (Figure 2C). For example, the two melanocortin receptor agonists setmelanotide and bremelanotide are clinically used to treat obesity and hypoactive sexual desire disorder in women, respectively (Kingsberg et al, 2019;Markham, 2021).…”

Section: Improvement and Expansion Of Lasso Peptide Function By Mutagenesismentioning

confidence: 99%

“…In particular, microbes produce peptide-derived secondary metabolites that exhibit a wide range of activities (Demain, 1999), including compounds that function in quorum-sensing (e.g., N-acyl homoserine lactones), agents that bind and transport metals (e.g., siderophores like enterobactin), and antibiotics that exert a survival advantage against other microbes (e.g., vancomycin) (Williams et al, 1989). Antibiotic resistance has outpaced the discovery of new antibiotics for years; antimicrobial peptides produced by microorganisms have thus attracted considerable attention as promising alternatives to the currently limited antibiotic pipeline (Neu, 1992;Newman and Cragg, 2020;Al Musaimi et al, 2021). Generally, peptide natural products can be classified into several families based on their biosynthetic machinery.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides

Wang

Fage

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Ribosomally synthesized and post-translationally modified peptides (RiPPs) are a growing family of natural products that exhibit a range of structures and bioactivities. Initially assembled from the twenty proteinogenic amino acids in a ribosome-dependent manner, RiPPs assume their peculiar bioactive structures through various post-translational modifications. The essential modifications representative of each subfamily of RiPP are performed on a precursor peptide by the so-called processing enzymes; however, various tailoring enzymes can also embellish the precursor peptide or processed peptide with additional functional groups. Lasso peptides are an interesting subfamily of RiPPs characterized by their unique lariat knot-like structure, wherein the C-terminal tail is inserted through a macrolactam ring fused by an isopeptide bond between the N-terminal amino group and an acidic side chain. Until recently, relatively few lasso peptides were found to be tailored with extra functional groups. Nevertheless, the development of new routes to diversify lasso peptides and thus introduce novel or enhanced biological, medicinally relevant, or catalytic properties is appealing. In this review, we highlight several strategies through which lasso peptides have been successfully modified and provide a brief overview of the latest findings on the tailoring of these peptides. We also propose future directions for lasso peptide tailoring as well as potential applications for these peptides in hybrid catalyst design.

show abstract

“…Additionally, over the last 14 decades numerous methods [3] enabling synthesis of a wide range of peptides [4] as well as their large‐scale manufacturing [5] were developed. Owing to their generally attractive pharmacological and safety profiles [6] peptides have been developed as many drugs, [7] with several new approvals appearing each year [8] . Further uses, for example, in material science, [9] cosmeceuticals, [10] and CO 2 capture, [11] have been found; however, despite this breadth of applications in recent years it has been recognized that the profound impact of peptide synthesis on the environment is untenable and more sustainable alternatives are urgently needed [12] .…”

Section: Methodsmentioning

confidence: 99%

Circular Aqueous Fmoc/t‐Bu Solid‐Phase Peptide Synthesis

Pawlas

Rasmussen

2021

ChemSusChem

View full text Add to dashboard Cite

Circular economy and aqueous synthesis are attractive concepts for sustainable chemistry. Here it is reported that the two can be combined in the universal method for peptide chemistry, fluorenylmethoxycarbonyl(Fmoc)/t‐Bu solid‐phase peptide synthesis (SPPS). It was demonstrated that Fmoc/t‐Bu SPPS could be performed under aqueous conditions using standard Fmoc amino acids (AAs) employing TentaGel S as resin and 4 : 1 mixture of water with inexpensive green solvent PolarClean. This resin/solvent combination played a crucial dual role by virtue of improving resin swelling and solubility of starting materials. In a model coupling, TCFH and 2,4,6‐collidine afforded a full conversion at only 1.3 equiv. AA, and these conditions were used in SPPS of Leu enkephaline amide affording the model peptide in 85 % yield and 86 % purity. A method to recycle the waste by filtration through a mixed ion exchange resin was developed, allowing reusing the waste without affecting quality of the peptide. The method herein obviates the use of unconventional or processed AAs in aqueous SPPS while using lower amounts of starting materials. By recycling/reusing SPPS waste the hazardous dipolar aprotic solvents used in SPPS were not only replaced with an aqueous medium, solvent use was also significantly reduced. This opens up a new direction in aqueous peptide chemistry in which efficient use of inexpensive starting materials and waste minimization is coupled with the universal Fmoc/t‐Bu SPPS.

show abstract

2020 FDA TIDES (Peptides and Oligonucleotides) Harvest

Cited by 59 publications

References 44 publications

Comparison between ¹⁸F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer

Comparison between ¹⁸F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer

Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides

Circular Aqueous Fmoc/t‐Bu Solid‐Phase Peptide Synthesis

Contact Info

Product

Resources

About

2020 FDA TIDES (Peptides and Oligonucleotides) Harvest

Cited by 59 publications

References 44 publications

Comparison between 18F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer

Comparison between 18F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer

Recent Advances and Perspectives on Expanding the Chemical Diversity of Lasso Peptides

Circular Aqueous Fmoc/t‐Bu Solid‐Phase Peptide Synthesis

Contact Info

Product

Resources

About

Comparison between ¹⁸F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer

Comparison between ¹⁸F‐DCFPyL PET and MRI for the detection of transition zone prostate cancer