201Tl-redistribution analysis in early and delayed myocordial scintigrams of patients with coronary heart disease (CHD)

Hör, G.; Sebening, H; Sauer, E.; Dressler, J.; Lutilsky, L; Wagner-Manslau, C.; Bofilias, I.; Wolf, Ingo; Pabst, H. W.

doi:10.1007/bf00263302

Cited by 11 publications

(2 citation statements)

References 21 publications

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“…The ( / is 0.0280 cm 2 .g -1 at 70 keV (gamma with maximum emitting percentage of 37%), heart muscle mass density  was adopted 1.05 g.cm -3 . From Eq.6, the specific gamma-ray constant for 201 Tl was 4.7 R. h -1 .mCi -1 at 1 cm. Thus, the mass energy-absorption coefficient of the heart muscle,  was 0.0294 cm -1 ; and, the S factor (Eq.…”

Section: Validationmentioning

confidence: 99%

“…[39] Despite the long-term application of MPI, spatial dose distribution at the myocardium during this procedure is poorly understood, due to the complex of radiopharmaceutical dynamics in such anatomic dynamic structure. Since 201 Tl is a good tracer for MPI, it has been applied in clinic for more than 20 years. [40] The present paper conducts a heart dosimetric investigation in MPI with Tl-201 radiopharmaceutical in order to elucidate the myocardium spatial imparted dose distribution.…”

Section: Introductionmentioning

confidence: 99%

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Dosimetria do Tl-201 em cintilografia de perfusão do miocárdio

Toledo

Trindade²,

Campos

2017

Sci. Plena

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Este trabalho conduz ao estudo da cintilografia de perfusão miocárdica, e investigação da dosimetria espacial do TI-201 distribuído no miocárdio. Métodos e Resultados: A manipulação de dados radiológicos foi realizado a fim de criar um modelo computacional do voxel do coração. Um conjunto de imagens obtidas por angiotomografia da aorta torácica e abdominal forneceu informações anatômicas e funcionais para a modelagem do coração no código SISCODES. A distribuição homogênea do TI-201 foi assumido no músculo cardíaco. Simulações do transporte de partículas através dos voxels e a interação com os tecidos do coração foram realizadas através do MCNP – Código Monte Carlo. A distribuição espacial de dose no modelo de coração é apresentado, bem como o histograma dose versus volume no músculo cardíaco. Para validação do estudo foi utilizado um modelo analítico. Conclusão: A presente ferramenta computacional gerou distribuição de dose espacial na cintilografia de perfusão do miocárdio. Especialmente, a dosimetria realizada elucida a dose transmitida no músculo cardíaco por unidade de atividade injetada de Tl-201, o que pode contribuir para futuras investigações de efeitos determinísticos no coração.

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Section: Validationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dosimetria do Tl-201 em cintilografia de perfusão do miocárdio

Toledo

Trindade²,

Campos

2017

Sci. Plena

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Myocardial Function Before and After Transluminal Coronary Angioplasty

KlepzigJr.

Scherer

Kober

et al. 1982

Transluminal Coronary Angioplasty and Intracoronary Thrombolysis

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Comparison of thallium-201 single-photon emission tomography after rest injection and fluorodeoxyglucose positron emission tomography for assessment of myocardial viability in patients with chronic coronary artery disease

Altehoeter¹,

Dahl²,

Buell³

et al. 1994

Eur J Nucl Med

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This prospective study in 42 patients with chronic coronary artery disease and severe wall motion abnormalities (sWMA) on cineventriculography (24 patients with previous myocardial infarction; ejection fraction, 45% +/- 13%) was designed to compare myocardial thallium-201 uptake after rest injection and normalized fluorodeoxyglucose (18FDG) uptake (after oral glucose load) for assessment of a rest 201Tl protocol to evaluate myocardial viability. The left ventricle was divided into the supply territory of the left anterior descending coronary artery (LAD) and the lateral wall and posterior territory (inferior, posterior and posteroseptal segments) because of the high variability of left circumflex and right coronary artery supply territories. Segmental 201Tl uptake in single-photon emission tomography (SPET) and segmental normalized 18FDG uptake (13 segments per patient) showed a close linear relationship in the LAD territory (r = 0.79) and in the lateral wall (r = 0.77), while the correlation in the posterior territory was considerably lower (r = 0.52). 201Tl/18FDG concordance was defined as an 18FDG uptake exceeding 201Tl uptake by < 20%. Discordance was assumed if 18FDG exceeded 201Tl uptake by at least 20%. Concordant results were shown by 81% (439/541) of segments. In segments with severe 201Tl reduction (< or = 50% of peak, n = 78) discordance was observed in 10% of segments in the LAD territory and lateral wall (n = 62) and in 44% of segments in the posterior territory (n = 16).(ABSTRACT TRUNCATED AT 250 WORDS)

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201Tl-redistribution analysis in early and delayed myocordial scintigrams of patients with coronary heart disease (CHD)

Cited by 11 publications

References 21 publications

Dosimetria do Tl-201 em cintilografia de perfusão do miocárdio

Dosimetria do Tl-201 em cintilografia de perfusão do miocárdio

Myocardial Function Before and After Transluminal Coronary Angioplasty

Comparison of thallium-201 single-photon emission tomography after rest injection and fluorodeoxyglucose positron emission tomography for assessment of myocardial viability in patients with chronic coronary artery disease

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