2017 Yearbook of Neurorestoratology

Huang, Hongyun; Skaper, Stephen D.; Mao, Gengsheng; Saberi, Hooshang; Feng, Shiqing; Jeon, Sang Ryong; Chen, Lin; Dimitrijevič, Milan R.

doi:10.26599/jnr.2018.9040001

Cited by 5 publications

(2 citation statements)

References 68 publications

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“…Toward this goal, the standards for cell culture and quality control described in this special issue and a recent publication on clinical cell therapy guidelines for neurorestoration [9] provide professional references for both cell culture and clinical applications. It is expected that continuous progresses in preclinical studies and clinical trials [10,11] should further improve the safety, quality and efficacy of cell therapy, which will inevitably benefit patients with neurological diseases.…”

Section: Perspectivesmentioning

confidence: 99%

A brief introduction to the Special Issue of cell culture standard and quality control in neurorestoratology

2018

Journal of Neurorestoratology

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Brief background Cell-based therapy has been attracting public attention as one of the potential modern therapeutic approaches to treat various diseases that are untreatable by conventional medicine. Several decades of biomedical research using various types of cells, including stem cells, indicates that appropriate cells can be used to promote neurorestoration for diseases from neurotrauma, injury to neurodegenerative diseases. Accumulating evidence from numerous preclinical and clinical studies demonstrated that cell-mediated neurorestoration may act through relaying or triggering signals, replacing, repairing or protecting the lost or damaged neural cells, filling the injury gap or providing critical factors to modulate environment, immune-modulating, sprouting axons, promoting neurogenesis and angiogenesis and enhance neurorestorative mechanisms [1−8]. In order to promote translation from bench-top preclinical research to bedside clinical practice, many issues need to be considered and solved. One of them is lack of international or professional cell culture standards and quality control for clinical using cells. The special issue reports the cell culture standards and quality control of common cell types in clinical application of Neurorestoratology, most of which is setup by Chinese Association of Neurorestoratology.

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Section: Perspectivesmentioning

confidence: 99%

A brief introduction to the Special Issue of cell culture standard and quality control in neurorestoratology

2018

Journal of Neurorestoratology

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“…Currently clinical neurorestorative therapies are able to help patients with central nervous system (CNS) diseases or damage for improving their neurological function and quality of life following complete chronic spinal cord injury (SCI), stroke, amyotrophic lateral sclerosis (ALS) and many other diseases [1,2]. Although, these advancements were made in due course of time [3,4]; incorrect viewpoints about clinical neurorestorative treatment strategies are still noticed in this area, with special reference to SCI. This appears to be a common misunderstanding that "there are no any methods for restoring damaged neurological structure or functions so far, or even partial restoration" [5].…”

Section: Introductionmentioning

confidence: 99%

Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

Huang

Sharma

Chen

et al. 2018

Journal of Neurorestoratology

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KEYWORDS neurorestorative strategies; spinal cord injury; cell therapy; neuromodulation; nerve bridges.Clinical neurorestorative therapies recently made great progress for patients with spinal cord injury (SCI). This paper systemically reviews historical perspectives, recent advancements and achievements in SCI through key neurorestorative strategies.In this study, a search was performed in the PubMed, Scopus, and Scholar Google search engines using the keywords "neurorestorative strategies", "spinal cord injury", "cell therapy", "neuromodulation", and "nerve bridges". Clinical studies published in the English language were included. It is paramount for academic community involved in this field to take the initiative of a multicenter randomized, double-blind, and placebo-control clinical study with high level of evidence-based treatments for most SCI neurorestorative strategies in patient management. It is of utmost need to establish standard therapeutic methods for patients with SCI as early as possible.

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Effects of microRNA-338 Transfection into Sciatic Nerve on Rats with Experimental Autoimmune Neuritis

Yuan

Wei

et al. 2020

J Mol Neurosci

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2017 Yearbook of Neurorestoratology

Cited by 5 publications

References 68 publications

A brief introduction to the Special Issue of cell culture standard and quality control in neurorestoratology

A brief introduction to the Special Issue of cell culture standard and quality control in neurorestoratology

Review of clinical neurorestorative strategies for spinal cord injury: Exploring history and latest progresses

Effects of microRNA-338 Transfection into Sciatic Nerve on Rats with Experimental Autoimmune Neuritis

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