2017 FDA Peptide Harvest

Abstract

approved by the FDA, with a total of forty-six. In turn, one of the highlights was the number of 14 peptides (six) included in this list. Here, the six peptides are analysed in terms of chemical structure, 15synthetic strategy used for their production, source, biological target, and mode of action. 16

Harnessing snake venom phospholipases A2 to novel approaches for overcoming antibiotic resistance

“…Hence, the recent revival of peptide‐based drugs both in academia and in the pharmaceutical industry comes with no surprise, as peptide therapeutics can address many unmet medical needs, by complementing or even replacing small molecules or large protein‐based therapeutics currently in the clinics (Craik, Fairlie, Liros, & Price, ; Henninot, Collins, & Nuss, ; Otvos Jr. & Wade, ). Accordingly, peptide drug sales have been steadily increasing, at present having an expected volume of sales likely over US$ 70 billion in 2019 (insulins included) (Henninot et al, ), and US$ 47 billion (insulins excluded) by 2024 (Al Musaimi, Al Shaer, de la Torre, & Albericio, ).…”

Greening Fmoc/tBu solid-phase peptide synthesis

“…Peptides play an important role in the fields of drug discovery and delivery [8][9][10], immunology [11], diagnostics [12], and biomaterials [13]. This relevance is attributed to their potential as drugs with high efficacy and minimal side effects.…”

“…Indeed, hundreds of peptides are currently being tested in preclinical trials. In addition, about 150 peptides have yielded promising results in clinical phases, and approximately 70 others are already on the market [8,9,14,15].…”

Expanding the Use of Dynamic Electrostatic Repulsion Reversed-Phase Chromatography: An Effective Elution Mode for Peptides Control and Analysis

“…They have also been shown to have several advantages, such as effectiveness at extremely low concentrations (due to their very high specificity) and their non-accumulation in the human body or the environment after being excreted. As a consequence of these advantages, the relevance of peptide pharmaceuticals (e.g., as antitumoral, anticoagulant, anti-hypertensive, antioxidant, antimicrobial drugs) began to increase [ 3 , 7 , 8 , 9 , 10 ].…”