2014 year in review: Cystic fibrosis

Abstract

In this article, we highlight cystic fibrosis (CF) research published in Pediatric Pulmonology during 2014, as well as related articles published in other journals.

Magnesium in cystic fibrosis—Systematic review of the literature

“…1 These agents also cause a shift of magnesium from the extra-to the intra-cellular compartment. 2 After lung transplant.…”

“…New therapies have entered the market and are part of the standard treatment of these patients . Now there are even more promising therapies directed at different components of the pathophysiology of the disease …”

“…1 Now there are even more promising therapies directed at different components of the pathophysiology of the disease. 2,3 Intriguingly, respiratory muscle weakness, inspissated mucus, increased airflow obstruction, and chronic pulmonary hypertension characterize both cystic fibrosis lung disease [1][2][3] and magnesium deficiency. 4,5 Nonetheless, textbooks and reviews only marginally address the possible association of magnesium deficiency with cystic fibrosis.…”

Una Paciente pediátrica diagnosticada con fibrosis quística con pronóstico reservado

“…(1,2) Esta induce alteraciones hidroelectrolíticas en las secreciones de las glándulas de vías respiratorias, digestivas, de las glándulas sudoríparas y del aparato genitourinario, lo que podrá conducir a infecciones crónicas. (3) Esa patología se presenta mayormente y con más letalidad en la raza caucásica, se calcula que en una tasa de 1 por cada 2.500 nacidos vivos. (4) Sin embargo, en los individuos de raza negra resulta mucho menor, en los que se estima una incidencia de 1 por cada 17.000 nacidos vivos.…”