Magnesium in cystic fibrosis—Systematic review of the literature

Santi, Maristella; Milani, Gregorio P.; Simonetti, Giacomo D.; Fossali, Emilio F.; Bianchetti, Mario G.; Lava, Sebastiano A. G.

doi:10.1002/ppul.23356

Cited by 11 publications

(11 citation statements)

References 39 publications

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“…LadS is stimulated by high calcium in the extracellular milieu (Broder et al, 2016). Further, recent work (Chakravarty et al, 2017) has reported that the inner membrane magnesium transporter MgtE, whose own expression is augmented during antibiotic pressure (Redelman et al, 2014) and low magnesium (both signals present in CF airway) (Coffey et al, 2014; Santi et al, 2016), signals through GacS to increase rsmYZ transcription. GacAS thus represents a hub of environmental regulation of the Rsm signaling.…”

Section: Pseudomonas Aeruginosamentioning

confidence: 99%

RNA-Dependent Regulation of Virulence in Pathogenic Bacteria

Chakravarty

Massé

2019

Front. Cell. Infect. Microbiol.

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During infection, bacterial pathogens successfully sense, respond and adapt to a myriad of harsh environments presented by the mammalian host. This exquisite level of adaptation requires a robust modulation of their physiological and metabolic features. Additionally, virulence determinants, which include host invasion, colonization and survival despite the host's immune responses and antimicrobial therapy, must be optimally orchestrated by the pathogen at all times during infection. This can only be achieved by tight coordination of gene expression. A large body of evidence implicate the prolific roles played by bacterial regulatory RNAs in mediating gene expression both at the transcriptional and post-transcriptional levels. This review describes mechanistic and regulatory aspects of bacterial regulatory RNAs and highlights how these molecules increase virulence efficiency in human pathogens. As illustrative examples, Staphylococcus aureus, Listeria monocytogenes, the uropathogenic strain of Escherichia coli, Helicobacter pylori, and Pseudomonas aeruginosa have been selected.

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Section: Pseudomonas Aeruginosamentioning

confidence: 99%

RNA-Dependent Regulation of Virulence in Pathogenic Bacteria

Chakravarty

Massé

2019

Front. Cell. Infect. Microbiol.

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“…deficiency is reported in patients with cystic fibrosis and is mainly due to four reasons; insufficient dietary intake, reduced intestinal absorption (due to pancreatic insufficiency associated with the disease), hyperglycemia associated with cystic fibrosis may trigger hypomagnesaemia and renal wasting associated with intake of drugs like b 2 agonists, thiazides, loop diuretics, calcineurin inhibitor, amino-glycoside antibiotics etc. (Lee et al 2015;Santi et al 2016). Recombinant human DNase is used for treatment purposes, and magnesium is essential for its activation (Santi et al 2016).…”

Section: Cystic Fibrosis Cystic Fibrosis Is An Autosomal Recessive Disorder Due To Mutation In the Cftr (Cystic Fibrosis Transmembrane Comentioning

confidence: 99%

“…(Lee et al 2015;Santi et al 2016). Recombinant human DNase is used for treatment purposes, and magnesium is essential for its activation (Santi et al 2016). Therefore the efficiency of the treatment is related to the Mg 2?…”

Section: Cystic Fibrosis Cystic Fibrosis Is An Autosomal Recessive Disorder Due To Mutation In the Cftr (Cystic Fibrosis Transmembrane Comentioning

confidence: 99%

“…Possible benefits of Mg 2? in cystic fibrosis treatments are improved respiratory muscle strength, pulmonary vasodilation in the case of pulmonary hypertension, and improved mucolytic activities of both endogenous and exogenous DNase (Santi et al 2016).…”

Section: Cystic Fibrosis Cystic Fibrosis Is An Autosomal Recessive Disorder Due To Mutation In the Cftr (Cystic Fibrosis Transmembrane Comentioning

confidence: 99%

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‘Magnesium’-the master cation-as a drug—possibilities and evidences

Mathew

Panonnummal

2021

Biometals

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Magnesium (Mg 2? ) is the 2nd most abundant intracellular cation, which participates in various enzymatic reactions; there by regulating vital biological functions. Magnesium (Mg 2? ) can regulate several cations, including sodium, potassium, and calcium; it consequently maintains physiological functions like impulse conduction, blood pressure, heart rhythm, and muscle contraction. But, it doesn't get much attention in account with its functions, making it a ''Forgotten cation''. Like other cations, maintenance of the normal physiological level of Mg 2? is important. Its deficiency is associated with various diseases, which point out to the importance of Mg 2? as a drug. The roles of Mg 2? such as natural calcium antagonist, glutamate NMDA receptor blocker, vasodilator, antioxidant and anti-inflammatory agent are responsible for its therapeutic benefits. Various salts of Mg 2? are currently in clinical use, but their application is limited. This review collates all the possible mechanisms behind the behavior of magnesium as a drug at different disease conditions with clinical shreds of evidence. Keywords Magnesium Á Calcium antagonist Á Hypomagnesemia Á NMDA blocker Á Forgotten cation Á Vasodilator Abbreviations ACE Angiotensin converting enzyme AD Alzheimer's disease (AD) ALP Alkaline phosphatase ALT Aminotransferase AMPA a-Amino-3-hydroxy-5-methyl-4isoxazolepropionic acid APP Amyloid precursor protein AST Aspartate aminotransferase ATP Adenosine triphosphate BBB Blood brain barrier BMD Bone mineral density BMP2 Bone morphogenetic protein 2 BP Blood pressure cAMP Cyclic Adenosine mono phosphate CAD Coronary arytery diseases CFTR Cystic fibrosis transmembrane conductance regulator CGRP Calcitonin gene related peptide CHF Congestive heart Failure Claudin CLDN CNS Central nervous system CSD Cortical spreading depression CSF Cerebrospinal fluid CTF b C terminal fragment b CVD Cardiovascular diseases

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“…Studies addressing the intracellular magnesium concentration and the kidney magnesium handling were also included. Chronic alcohol-use disorder subjects in treatment with drugs with a potential to cause hypomagnesemia such as aminoglycosides, calcineurin inhibitors, diuretics, or proton-pump inhibitors were excluded [4,7,8].…”

Section: Selection Criteriamentioning

confidence: 99%

Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review

et al. 2021

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Chronic alcohol-use disorder has been imputed as a possible cause of dietary magnesium depletion. The purpose of this study was to assess the prevalence of hypomagnesemia in chronic alcohol-use disorder, and to provide information on intracellular magnesium and on its renal handling. We carried out a structured literature search up to November 2020, which returned 2719 potentially relevant records. After excluding non-significant records, 25 were retained for the final analysis. The meta-analysis disclosed that both total and ionized circulating magnesium are markedly reduced in chronic alcohol-use disorder. The funnel plot and the Egger’s test did not disclose significant publication bias. The I2-test demonstrated significant statistical heterogeneity between studies. We also found that the skeletal muscle magnesium content is reduced and the kidney’s normal response to hypomagnesemia is blunted. In conclusion, magnesium depletion is common in chronic alcohol-use disorder. Furthermore, the kidney plays a crucial role in the development of magnesium depletion.

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Magnesium in cystic fibrosis—Systematic review of the literature

Cited by 11 publications

References 39 publications

RNA-Dependent Regulation of Virulence in Pathogenic Bacteria

RNA-Dependent Regulation of Virulence in Pathogenic Bacteria

‘Magnesium’-the master cation-as a drug—possibilities and evidences

Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review

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