2013 IFT International Food Nanoscience Conference: Proceedings

Newsome, Rosetta

doi:10.1111/1541-4337.12055

Cited by 12 publications

(2 citation statements)

References 77 publications

(89 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…pH, secretion of digestive fluids) and transit times (Helbig et al 2013 ; Kong and Singh 2010 ; Minekus et al 1995 ; Wickham et al 2009 ; Zangenberg et al 2001 ). Such a dynamic computer controlled model was used to study the behaviour of engineered nanoclay materials (Newsome 2014 ).…”

Section: Gut In Vitro Modelsmentioning

confidence: 99%

Progress and future of in vitro models to study translocation of nanoparticles

et al. 2015

View full text Add to dashboard Cite

The increasing use of nanoparticles in products likely results in increased exposure of both workers and consumers. Because of their small size, there are concerns that nanoparticles unintentionally cross the barriers of the human body. Several in vivo rodent studies show that, dependent on the exposure route, time, and concentration, and their characteristics, nanoparticles can cross the lung, gut, skin, and placental barrier. This review aims to evaluate the performance of in vitro models that mimic the barriers of the human body, with a focus on the lung, gut, skin, and placental barrier. For these barriers, in vitro models of varying complexity are available, ranging from single-cell-type monolayer to multi-cell (3D) models. Only a few studies are available that allow comparison of the in vitro translocation to in vivo data. This situation could change since the availability of analytical detection techniques is no longer a limiting factor for this comparison. We conclude that to further develop in vitro models to be used in risk assessment, the current strategy to improve the models to more closely mimic the human situation by using co-cultures of different cell types and microfluidic approaches to better control the tissue microenvironments are essential. At the current state of the art, the in vitro models do not yet allow prediction of absolute transfer rates but they do support the definition of relative transfer rates and can thus help to reduce animal testing by setting priorities for subsequent in vivo testing.

show abstract

Section: Gut In Vitro Modelsmentioning

confidence: 99%

Progress and future of in vitro models to study translocation of nanoparticles

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Based on these facts, codification and unification of regulation requirements for nanotechnology and preparation and application of NPs especially in relation to nature, environment and health is strongly needed [415][416][417]. The Organisation for Economic Co-operation and Development (OECD) Working Party on Manufactured Nanomaterials (WPMN), which is comprised primarily of regulators from various countries, is looking to share information among the countries about regulatory actions and voluntary programs and the data they have or need for discussions relating to regulatory decisions [418,419].…”

Section: Nanoecotoxicology Health Risks and Regulationsmentioning

confidence: 99%

Application Of Nanotechnology In Agriculture And Food Industry, Its Prospects And Risks

Jampílek

Kráľová

2015

Ecological Chemistry and Engineering S

View full text Add to dashboard Cite

Nanoagrochemicals, such as nanopesticides, nanofertilizers or plant growth stimulating nanosystems, were primarily designed to increase solubility, enhance bioavailability, targeted delivery, controlled release and/or protection against degradation resulting in the reduced amount of applied active ingredients and finally in a decrease of dose-dependent toxicity/burden. This paper is a comprehensive up-to-date review related to the preparation and the biological activity of nanoformulations enabling gradual release of active ingredient into weeds and the body of pests and controlled release of nutrients to plants. The attention is also devoted to the decrease of direct environmental burden and economic benefits due to application of nanoformulations, where less amount of active ingredient is needed to achieve the same biological effect in comparison with bulk. The application of nanotechnology in the areas such as food packaging, food security, encapsulation of nutrients and development of new functional products is analysed. The use of nanoparticles in biosensors for detection of pathogens and contaminants as well as in DNA and gene delivery is discussed as well. Benefits and health risks of nanoagrochemicals are highlighted, and special attention is given to nanoecotoxicology and guidelines and regulatory documents related to the use of nanoformulations in agriculture and food industry.

show abstract