2013 Dengue Outbreaks in Singapore and Malaysia Caused by Different Viral Strains

Ng, Lee Ching; Chem, Yu-kie; Koo, Carmen; Mudin, Rose Nani; Amin, Faridah; Lee, Kim-Sung; Kheong, Chong Chee

doi:10.4269/ajtmh.14-0588

Cited by 61 publications

(60 citation statements)

References 18 publications

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“…DENV-3 was used as a reference DENV serotype because it is widespread in South-East Asia, [48][49][50][51] and was kindly provided by the National Public Health Laboratory (NPHL), Singapore. DENV-3 was used as a reference DENV serotype because it is widespread in South-East Asia, [48][49][50][51] and was kindly provided by the National Public Health Laboratory (NPHL), Singapore.…”

Section: Virusesmentioning

confidence: 99%

Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients

et al. 2019

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Objectives Recent Zika virus (ZIKV) outbreaks challenged existing laboratory diagnostic standards, especially for serology‐based methods. Because of the genetic and structural similarity of ZIKV with other flaviviruses, this results in cross‐reactive antibodies, which confounds serological interpretations. Methods Plasma from Singapore ZIKV patients was screened longitudinally for antibody responses and neutralising capacities against ZIKV. Samples from healthy controls, ZIKV patients and DENV patients were further assessed using ZIKV and DENV peptides of precursor membrane (prM), envelope (E) or non‐structural 1 (NS1) viral proteins in a peptide‐based ELISA for epitope identification. Identified epitopes were re‐validated and diagnostically evaluated using sera of patients with DENV, bacteria or unknown infections from Thailand. Results Long‐lasting ZIKV‐neutralising antibodies were elicited during ZIKV infection. Thirteen potential linear B‐cell epitopes were identified, and of these, four common flavivirus, three ZIKV‐specific and one DENV‐specific differential epitopes had more than 50% sensitivity and specificity. Notably, ZIKV‐specific peptide 26 on domain I/II of E protein (amino acid residues 271–288) presented 80% sensitivity and 85.7% specificity. Importantly, the differential epitopes also showed significance in differentiating non‐flavivirus patient samples. Conclusion Linear B‐cell epitope candidates to differentiate between ZIKV and DENV infections were identified, providing the first step towards the design of a much‐needed serology‐based assay.

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Section: Virusesmentioning

confidence: 99%

Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients

et al. 2019

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“…The area is one of the homelands of overseas Chinese, especially to the those live in Southeast Asia, which brings about many travels from there each year. Dengue is endemic in Southeast Asia, with severe dengue outbreaks in Indonesia, Thailand, Singapore and Malaysia in 2013 [38–40]. These countries are tourism resorts and there have been intensive trade activities between these countries and the PRD.…”

Section: Discussionmentioning

confidence: 99%

The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013

Sang

Wang

et al. 2016

PLoS Negl Trop Dis

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BackgroundThere was a dengue epidemic in several regions of China in 2013. No study has explored the dynamics of dengue transmission between different geographical locations with dengue outbreaks in China. The purpose of the study is to analyze the epidemiological characteristics and to explore the dynamic transmission of dengue in China, 2013.Methodology and Principal FindingsRecords of dengue cases of 2013 were obtained from the China Notifiable Disease Surveillance System. Full E-gene sequences of dengue virus detected from the outbreak regions of China were download from GenBank. Geographical Information System and heatmaps were used to describe the epidemiological characteristics. Maximum Likelihood phylogenetic and Bayesian phylogeographic analyses were conducted to explore the dengue dynamic transmission. Yunnan Province and Guangdong Province had the highest imported cases in the 2013 epidemic. In the locations with local dengue transmission, most of imported cases occurred from June to November 2013 while local dengue cases developed from July to December, 2013. There were significant variations for the incidences of dengue, in terms of age distributions, among different geographic locations. However, gender differences were identified in Guangzhou, Foshan and Xishuangbanna. DENV 1–3 were detected in all locations with the disease outbreaks. Some genotypes were detected in more than one locations and more than one genotypes have been detected in several locations. The dengue viruses introduced to outbreak areas were predominantly from Southeast Asia. In Guangdong Province, the phylogeographical results indicated that dengue viruses of DENV 1 were transmitted to neighboring cities Foshan and Zhongshan from Guangzhou city, and then transmitted to Jiangmen city. The virus in DENV 3 was introduced to Guangzhou city, Guangdong Province from Xishuangbanna prefecture, Yunnan Province.ConclusionsRepeated dengue virus introductions from Southeast Asia and subsequent domestic dengue transmission within different regions may have contributed to the dengue epidemics in China, 2013.

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“…During the past 2 years (2014-2015) outbreaks of DF have also been reported in our neighboring countries such as China, 12 Japan, 18 Malaysia, 19 and Singapore. 19 This reminds us that we ought to pay more attention to this infectious disease as it is becoming an issue in southeastern Asian countries. We suggest that active surveillance systems, mosquito vector monitoring, and development of fast diagnostic assays and dengue vaccine should be reinforced for effective control of DENV infection and dissemination.…”

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confidence: 99%

Severe Dengue Fever Outbreak in Taiwan

Wang

Chang

et al. 2016

The American Society of Tropical Medicine and Hygiene

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Abstract. Dengue fever (DF) is a vector-borne disease caused by dengue viruses (DENVs). Epidemic dengue occurs intermittently in Taiwan. In 2014, Taiwan experienced its largest DF outbreak. There were 15,732 DF cases reported. There were a total of 136 dengue hemorrhagic fever (DHF) cases, of which 20 resulted in death. Most DF cases were reported in southern Taiwan. A total of 15,043 (96%) cases were from Kaohsiung, a modern city in southern Taiwan. This report reviews DF epidemics in Taiwan during [2005][2006][2007][2008][2009][2010][2011][2012][2013][2014]. The correlation between DF and DHF along with temperature and precipitation were conjointly examined. We conclude that most dengue epidemics in Taiwan resulted from imported DF cases. Results indicate three main factors that may have been associated with this DF outbreak in Kaohsiung: an underground pipeline explosion combined with subsequent rainfall and higher temperature. These factors may have enhanced mosquito breeding activity, facilitating DENV transmission.Dengue fever (DF) is caused by dengue viruses (DENVs) infection. It is a mosquito-borne viral disease in tropical and subtropical regions of the world.

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2013 Dengue Outbreaks in Singapore and Malaysia Caused by Different Viral Strains

Cited by 61 publications

References 18 publications

Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients

Novel differential linear B‐cell epitopes to identify Zika and dengue virus infections in patients

The Epidemiological Characteristics and Dynamic Transmission of Dengue in China, 2013

Severe Dengue Fever Outbreak in Taiwan

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