Severe Dengue Fever Outbreak in Taiwan

Wang, Sheng-Fan; Wang, Wen Hung; Chang, Ko; Chen, Yen Hsu; Tseng, Sung-Pin; Yen, Chia-Hung; Wu, Deng Chyang; Chen, Yi Ming Arthur

doi:10.4269/ajtmh.15-0422

Cited by 61 publications

(62 citation statements)

References 17 publications

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“…4 We previously reported a correlation between the underground pipeline leaking gas explosion event, which was followed by continuous heavy rains, with the 2014 DF outbreak in Kaohsiung ( P <0.0001; r =0.87). 5 The cavities created by the explosion might have led to an increase in stagnant waters suitable for breeding of the Aedes mosquitoes. We found that the Breteau index for measuring the density of mosquitoes increased from 10%–19% to 35%–49% from July to September in Kaohsiung.…”

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confidence: 99%

Consecutive large dengue outbreaks in Taiwan in 2014–2015

Wang

Chang

Loh

et al. 2016

Emerging Microbes & Infections

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confidence: 99%

Consecutive large dengue outbreaks in Taiwan in 2014–2015

Wang

Chang

Loh

et al. 2016

Emerging Microbes & Infections

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“…6 This unique epidemiologic pattern has been unchanged in the past decade, with annual numbers of fatal cases ranging from 0 to 7. 7 However, in 2014, an unprecedented dengue outbreak, involving more than 15,000 infections, including 136 DHF cases and 20 fatalities, occurred, 8 followed by an even larger outbreak in 2015. These outbreaks suggest that dengue may have become endemic to Taiwan and that occurrence of tens of thousands of DENV infections annually might be not uncommon in future.…”

Section: Introductionmentioning

confidence: 99%

Characteristics and Risk Factors for Fatality in Patients with Dengue Hemorrhagic Fever, Taiwan, 2014

Wei¹,

Shu

Hung³

2016

The American Society of Tropical Medicine and Hygiene

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Abstract. An unprecedented dengue outbreak involving more than 15,000 infections, including 136 dengue hemorrhagic fever (DHF) cases and 20 fatalities, occurred in Taiwan in 2014. The median age of the DHF cases was 71 years (range: 4-92 years) and most of them (N = 100, 73.5%) had comorbidities, of which the majority were hypertension (56%) and diabetes mellitus (DM; 27%). Only approximately half of the DHF cases (59/136) were classified as severe dengue, based on the 2009 WHO-revised dengue classification. The fatality rate for this DHF outbreak was 14.7%. DM (odds ratio [OR] = 3.60, 95% confidence interval [CI] = 1.22-10.63) and presentation with severe plasma leakage (OR = 6.42, 95% CI = 1.76-23.63) were independent risk factors for fatality.

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“…Imported dengue has also caused local outbreaks in the United States and Japan [8,9]. Imported dengue fever cases frequently caused disastrous epidemics with thousands of patients in Taiwan [10,11]. Previous studies in Taiwan have revealed that a systematic approach to identifying infected passengers could minimize the risk of local transmissions of virus and outbreaks [12,13].…”

Section: Introductionmentioning

confidence: 99%

Clinical and epidemiological characteristics of imported dengue fever among inbound passengers: Infrared thermometer–based active surveillance at an international airport

Wang

et al. 2019

PLoS ONE

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BackgroundDengue fever is endemic in tropical and subtropical areas, especially Southeast Asia. International air travel facilitates the spread of dengue across and within borders. To date, no predictive factors have been established for assessing risk of dengue among febrile travelers.MethodsSince 2006, Taiwan has operated a program of infrared thermometer–based non-contact active surveillance at Taoyuan International Airport (TPE). All inbound passengers from dengue-endemic countries who are febrile (tympanic temperature ≥38°C) undergo routine laboratory testing for dengue. We analyzed clinical and epidemiological characteristics of all tested passengers entering Taiwan via TPE in 2011 to identify the predictive factors of dengue infection.ResultsIn 2011, of the 3,719 febrile passengers from dengue-endemic countries, 74 (2.0%) had laboratory-confirmed dengue infection. Multivariable logistic regression analysis revealed that those who were aged ≥60 years (adjusted odds ratio [aOR], 8.7; 95% confidence interval [CI], 2.6–29.6) and had self-reported fever (aOR, 2.5; 95% CI, 1.5–4.1), skin rashes (aOR, 11.0; 95% CI, 3.4–35.1), or a tympanic temperature ≥39°C (aOR, 2.9; 95% CI, 1.7–4.9) were significantly more likely to have dengue (all p values < 0.05). Compared with travelers who stayed in dengue-endemic countries for ≤7 days, those who traveled 8–14, 15–21, 22–28, and ≥29 days were also more likely to be infected (aORs of 10.2, 14.9, 39.0 and 12.0, respectively).ConclusionThese clinical and epidemiological features can facilitate timely recognition and diagnosis of imported dengue in febrile inbound passengers and therefore help prevent domestic transmission of dengue virus.

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Severe Dengue Fever Outbreak in Taiwan

Cited by 61 publications

References 17 publications

Consecutive large dengue outbreaks in Taiwan in 2014–2015

Consecutive large dengue outbreaks in Taiwan in 2014–2015

Characteristics and Risk Factors for Fatality in Patients with Dengue Hemorrhagic Fever, Taiwan, 2014

Clinical and epidemiological characteristics of imported dengue fever among inbound passengers: Infrared thermometer–based active surveillance at an international airport

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