2012 American Geriatrics Society Beers Criteria: Enhanced Applicability for Detecting Potentially Inappropriate Medications in <scp>E</scp>uropean Older Adults? A Comparison with the Screening Tool of Older Person's Potentially Inappropriate Prescriptions

Blanco-Reina, Encarnación; Ariza-Zafra, Gabriel; Ocaña-Riola, Ricardo; Ortiz, Matilde León

doi:10.1111/jgs.12891

Cited by 92 publications

(109 citation statements)

References 46 publications

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“…Resultados semelhantes têm sido observados em investigações internacionais 30,31,32 e brasileiras 23,24,36 . Como já relatado em estudos anteriores, a polifarmácia tem sido associada a resultados negativos em saúde, como, por exemplo, reações adversas, interações medicamentosas, baixa adesão e síndromes geriátricas 9,37,38 .…”

Section: Métodosunclassified

Uso de medicamentos potencialmente inadequados entre idosos do Município de Viçosa, Minas Gerais, Brasil: um inquérito de base populacional

et al. 2015

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Resumo Avaliou-se o uso de medicamentos potencialmente inadequados entre idosos de Viçosa, Minas Gerais, Brasil, de acordo com os critérios de Beers 2012 e STOPP, bem como os fatores associados a esse uso. Estudo transversal com 621 idosos não institucionalizados, abordados por entrevista domiciliar. As variáveis explicativas foram sexo, idade, escolaridade, percepção da saúde, restrição de atividades nos últimos 15 dias, capacidade funcional, história de internação hospitalar, número de doenças autorreferidas e polifarmácia. Realizou-se análise de regressão de Poisson multivariada. Observou-se alta prevalência de uso de medicamentos potencialmente inadequados, 43,8% (IC95%: 37,8%-47,8%) e 44,8% (IC95%: 40,9%-48,8%), segundo os critérios de Beers 2012 e STOPP respectivamente. Sexo feminino e polifarmácia se mantiveram independentemente associados ao uso de medicamentos potencialmente inadequados, de acordo com os critérios de Beers. Para o critério STOPP, as variáveis independentemente associadas ao uso de medicamentos potencialmente inadequados foram sexo feminino, percepção de saúde regular e polifarmácia. Esforços são necessários para se qualificar a prática da polifarmácia entre idosos.

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Section: Métodosunclassified

Uso de medicamentos potencialmente inadequados entre idosos do Município de Viçosa, Minas Gerais, Brasil: um inquérito de base populacional

et al. 2015

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“…Among identified adverse drug events, preventable adverse drug events have been reported to be 27% in primary care and 42% in long-term care, where prescribing and monitoring stages of pharmaceutical care were emphasized for prevention of adverse drug events (6,7). Potentially inappropriate medications have been identified in Beers Criteria (8), which aimed to prevent poor outcomes in elderly patients such as ADRs, hospitalization, morbidity, or mortality (8). In the elderly population DDIs can be diagnosed as severe adverse outcomes (9).…”

Section: Introductionmentioning

confidence: 99%

Potential drug–drug interactions among prescriptionsfor elderly patients in primary health care

Gören¹,

Demirkapu²,

Acet³

et al. 2017

Turk J Med Sci

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IntroductionAlthough combination therapies are generally used to achieve better therapeutic results, drug-drug interactions (DDIs) can lead to life-threatening adverse reactions (ADRs) or therapeutic failure by changing the therapeutic efficacy of drugs. DDIs have been reported to cause 4% of drug-related emergency visits (1). Changes in the pharmacokinetic properties of drugs may produce adverse drug reactions or therapeutic failure. The pharmacodynamics of DDIs can produce additive, synergistic, or antagonistic pharmacological effects (2).ADRs can be considered an important public health problem, particularly in the elderly patients (3). Polypharmacy and DDIs play critical roles in the production of ADRs and are related to an increased risk of mortality (4,5). Among identified adverse drug events, preventable adverse drug events have been reported to be 27% in primary care and 42% in long-term care, where prescribing and monitoring stages of pharmaceutical care were emphasized for prevention of adverse drug events (6,7). Potentially inappropriate medications have been identified in Beers Criteria (8), which aimed to prevent poor outcomes in elderly patients such as ADRs, hospitalization, morbidity, or mortality (8). In the elderly population DDIs can be diagnosed as severe adverse outcomes (9). Increased sensitivity to DDIs in elderly patients and the most frequent ADRs experienced by this age group have been shown in many studies (10-12). Elderly patients exposed to polypharmacy are at high risk of DDIs that depend on agerelated changes in pharmacokinetics or pharmacodynamics of drugs, and multiple co-morbidities.Another important factor for the increased vulnerability of elderly patients to DDIs can be poor compliance, underuse, overuse, or misuse of the medications (13). Moreover, elderly patients who will undergo surgical treatment or treatment in an intensive care unit have been reported to have a high risk for the occurrence of DDIs ( 14). Although there are publications investigating the use of inappropriate drugs in Turkish elderly patients (15,16), there are no data evaluating potential DDIs in Turkish elderly patients.Background/aim: Elderly patients are at high risk from drug-drug interactions (DDIs). This study evaluates the potential DDIs in Turkish elderly patients at a primary health care outpatient clinic. Materials and methods:Online database systems were used to examine DDIs on the prescriptions of patients (n = 1206). The clinical severity of DDIs was classified by the Lexi-Interact Online database.Results: Of the 5059 prescriptions, 33% were found to have DDIs. We detected 29 (0.9%) A, 380 (11.8%) B, 2494 (77.7%) C, 289 (9%) D, and 18 (0.6%) X risk rating category DDIs among the prescriptions. Prescriptions of female patients and patients aged between 65 and 72 years showed significantly higher number of DDIs. The frequency of DDIs increased both with the number of drugs and combined preparations per prescription. Acetylsalicylic acid and salbutamol were the most frequently prescribed drugs ...

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“…Other studies have also reported high prevalence of prescription of non-steroid anti-inflammatory drugs (NSAIDs) detected by 2008 STOPP (Ubeda et al, 2012;Blanco-Reina et al, 2014;Vezmar Kovačević et al, 2014). Even though the international guidelines continue to indicate low-dose aspirin for reducing cardiovascular risk, this benefit may not overcome the risk of gastrointestinal bleeding in older patients (Lanas, Polo-Tomás, CasadoArroyo, 2013;Ikeda et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

“…Amitriptyline was considered a PIM in a few cases by both criteria, while aspirin was a major PIM according to 2008 STOPP but a minor PIM by 2003 Beers. It has been suggested that the use of both 2012 Beers and 2008 STOPP may be complementary to detect PIMs in older adults (Blanco-Reina et al, 2014). However, a general guideline including these lists may not be suitable for all populations, considering that the medications approved for commercialization may differ between countries.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Exposure to potentially inappropriate medications in Brazilian elderly outpatients with metabolic diseases

Martins

Mori

Dórea

et al. 2016

Braz. J. Pharm. Sci.

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2012 American Geriatrics Society Beers Criteria: Enhanced Applicability for Detecting Potentially Inappropriate Medications in European Older Adults? A Comparison with the Screening Tool of Older Person's Potentially Inappropriate Prescriptions

Abstract: The 2012 Beers criteria detected the highest number of PIMs, and given the scant overlapping with the STOPP criteria, the use of both tools may be seen as complementary.

Cited by 92 publications

References 46 publications

Uso de medicamentos potencialmente inadequados entre idosos do Município de Viçosa, Minas Gerais, Brasil: um inquérito de base populacional

Uso de medicamentos potencialmente inadequados entre idosos do Município de Viçosa, Minas Gerais, Brasil: um inquérito de base populacional

Potential drug–drug interactions among prescriptionsfor elderly patients in primary health care

Exposure to potentially inappropriate medications in Brazilian elderly outpatients with metabolic diseases

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