201 Tl, 99m Tc-MIBI, 99m Tc-tetrofosmin and 99m Tc-furifosmin: relative retention and clearance kinetics in retrogradely perfused guinea pig hearts

Schaefer, Wolfgang M.; Moka, D.; Brockmann, Holger; Schomaecker, Klaus; Schicha, H.

doi:10.1016/s0969-8051(01)00288-8

Cited by 16 publications

(17 citation statements)

References 22 publications

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“…7,2~ Despite the difference in fractional mitochondrial retention for MIBI and TF, Schaefer et al reported that the initial cellular uptake of these tracers should be the same . 7 Although it has been reported that both have similar properties, MIBI seems to be more suitable than TF for the detection of myocardial reversibility and viability since it accumulates mostly inside the mitochondria where the washout is much slower than the cytosol, this conflicts with our results. We think that this situation is related to the faster clearance of TF from the extra-cardiac organs, and application of rest study first with low dose for real rest imaging.…”

Section: Discussioncontrasting

confidence: 99%

“…Despite the difference in fractional mitochondrial retention between MIBI and TF, Schaefer et al reported that the initial cellular uptake of these tracers should be the same/Although, both have similar properties, MIBI seems to be more suitable than TF for the detection of myocardial reversibility and viability since it accumulates mostly inside the mitochondria. 7 Certainly, besides radiopharmaceutical selection and imaging protocols, the clinical condition of the patient and stress techniques are also important in myocardial perfusion imaging. Although both tracers have similar physiologic characteristics, to our knowledge, adequate clinical investigations which simultaneously compare the diagnostic effectiveness of these tracers in CAD especially in patients unable to perform treadmill exercise or unsuitable for pharmacological vasodilator stress testing have yet to be performed.…”

Section: Introductionmentioning

confidence: 99%

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Dobutamine stress tetrofosmin SPECT; evaluation of short rest-stress protocol and head to head comparison with MIBI in detection of coronary artery disease

2005

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MIBI and TF showed similar perfusion defects and good segmental correlation during dobutamine stress with the same quality images. Both radiopharmaceuticals may be acceptable with this imaging protocol. Besides this, TF study showed better reversibility degree (55%) in a shorter time when compared to MIBI study (25%) in perfusion defects (especially in segments with severely decreased perfusion or no uptake).

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Section: Discussioncontrasting

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dobutamine stress tetrofosmin SPECT; evaluation of short rest-stress protocol and head to head comparison with MIBI in detection of coronary artery disease

2005

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“…The present study not only confirmed stable 18 F-FBnTP distribution without redistribution, comparable to 99m Tcsestamibi and 99m Tc-tetrofosmin (17), but also added new information to prior work. First, it showed that 18 F-FBnTP detects perfusion defects accurately in rats, using smallanimal imaging, whereas prior results were obtained in dogs.…”

Section: Discussionsupporting

confidence: 81%

Stable Delineation of the Ischemic Area by the PET Perfusion Tracer ¹⁸F-Fluorobenzyl Triphenyl Phosphonium After Transient Coronary Occlusion

Higuchi¹,

Fukui

Rischpler

et al. 2011

J Nucl Med

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18 F-fluorobenzyl triphenyl phosphonium (FBnTP) has recently been introduced as a myocardial perfusion PET agent. We used a rat model of transient coronary occlusion to determine the stability of the perfusion defect size over time and the magnitude of redistribution. Methods: Wistar rats (n 5 15) underwent thoracotomy and 2-min occlusion of the left coronary artery (LCA), followed by reperfusion. During occlusion, 18 F-FBnTP (92.5 MBq) and 201 Tl-thallium chloride (0.74 MBq) were injected intravenously. One minute before the animals were sacrificed at 5, 45, and 120 min after reperfusion, the LCA was occluded again and 2% Evans blue was injected intravenously to determine the ischemic territory. The hearts were excised, frozen, and sliced for serial dual-tracer autoradiography and histology. Dynamic in vivo 18 F-FBnTP PET was performed on a subgroup of animals (n 5 4). Results: 18 F-FBnTP showed stable ischemic defects at all time points after tracer injection and reperfusion. The defects matched the blue dye defect (y 5 0.97x11.5, R 2 5 0.94, y 5 blue-dye defect, x 5 18 F-FBnTP defect). Count density analysis showed no defect fill-in at 45 min but slightly increased activity at 120 min (LCA/remote uptake ratio 5 0.19 6 0.02, 0.19 6 0.05, and 0.34 6 0.06 at 5, 45, and 120 min, respectively, P , 0.05). For comparison, 201 Tl showed complete redistribution at 120 min (LCA/remote 5 0.42 6 0.04, 0.72 6 0.03, and 0.97 6 0.05 at 5, 45, and 120 min, respectively, P , 0.001). Persistence of the 18 F-FBnTP defect over time was confirmed by in vivo dynamic small-animal PET. Conclusion: In a transient coronary occlusion model, perfusion defect size using the new PET agent 18 F-FBnTP remained stable for at least 45 min and matched the histologically defined ischemic area. This lack of significant redistribution suggests a sufficient time window for future clinical protocols with tracer injection remote from the scanner, such as in a stress testing laboratory or chest pain unit. PET myocardial perfusion imaging is increasingly entering the clinical arena as a highly accurate technique for the workup of coronary artery disease (1,2). When compared with standard SPECT, it provides better temporal and spatial resolution, higher sensitivity for tracer detection, and robust correction of attenuation artifacts (3,4). The currently established PET myocardial perfusion tracers include 82 Rb-rubidium chloride, 13 N-ammonia, and 15 Owater, but their short radioactive half-lives (76 s, 10 min, and 2.1 min, respectively) require expensive on-site production by a cyclotron or commitment to a dedicated generator. Additionally, a physical-exercise stress test is not practical because of the rapid decay of these tracers.18 F-fluorobenzyl triphenyl phosphonium (FBnTP) is one of several recently introduced 18 F-labeled perfusion tracers. It is a cation with a mechanism of uptake similar to 99m Tctetrofosmin and 99m Tc-sestamibi and has shown promising properties such as high cardiac uptake and retention in animal models (5-8). Because of t...

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“…(The intracellular distribution of MIBI mainly depends on mitochondrial membrane potential, and that of TF is related to cytosolic and mitochondrial accumulation.) [16][17][18][19][20]. In the present study, the k 2 values of TF and MIBI differed in the normal control group, and the k 2TF value was nearly tenfold greater than that of k 2MIBI .…”

Section: Discussionmentioning

confidence: 62%

Myocardial kinetics of 201Thallium, 99mTc-tetrofosmin, and 99mTc-sestamibi in an acute ischemia–reperfusion model using isolated rat heart

et al. 2007

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Tracer extraction was higher for TL than for the (99m)Tc tracers and all tracers decreased according to the severity of ischemia-reperfusion in the three tracer groups. The clearance kinetics of not only MIBI but also TF is possibly useful for the evaluation of the severity of ischemia, and the Langendorff method and a methodological approach by continuous determinations of radioactivity may serve for the quantitative analysis of tracer kinetic profiles.

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201 Tl, 99m Tc-MIBI, 99m Tc-tetrofosmin and 99m Tc-furifosmin: relative retention and clearance kinetics in retrogradely perfused guinea pig hearts

Cited by 16 publications

References 22 publications

Dobutamine stress tetrofosmin SPECT; evaluation of short rest-stress protocol and head to head comparison with MIBI in detection of coronary artery disease

Dobutamine stress tetrofosmin SPECT; evaluation of short rest-stress protocol and head to head comparison with MIBI in detection of coronary artery disease

Stable Delineation of the Ischemic Area by the PET Perfusion Tracer ¹⁸F-Fluorobenzyl Triphenyl Phosphonium After Transient Coronary Occlusion

Myocardial kinetics of 201Thallium, 99mTc-tetrofosmin, and 99mTc-sestamibi in an acute ischemia–reperfusion model using isolated rat heart

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201 Tl, 99m Tc-MIBI, 99m Tc-tetrofosmin and 99m Tc-furifosmin: relative retention and clearance kinetics in retrogradely perfused guinea pig hearts

Cited by 16 publications

References 22 publications

Dobutamine stress tetrofosmin SPECT; evaluation of short rest-stress protocol and head to head comparison with MIBI in detection of coronary artery disease

Dobutamine stress tetrofosmin SPECT; evaluation of short rest-stress protocol and head to head comparison with MIBI in detection of coronary artery disease

Stable Delineation of the Ischemic Area by the PET Perfusion Tracer 18F-Fluorobenzyl Triphenyl Phosphonium After Transient Coronary Occlusion

Myocardial kinetics of 201Thallium, 99mTc-tetrofosmin, and 99mTc-sestamibi in an acute ischemia–reperfusion model using isolated rat heart

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Stable Delineation of the Ischemic Area by the PET Perfusion Tracer ¹⁸F-Fluorobenzyl Triphenyl Phosphonium After Transient Coronary Occlusion