Myocardial kinetics of 201Thallium, 99mTc-tetrofosmin, and 99mTc-sestamibi in an acute ischemia–reperfusion model using isolated rat heart

Abstract

Tracer extraction was higher for TL than for the (99m)Tc tracers and all tracers decreased according to the severity of ischemia-reperfusion in the three tracer groups. The clearance kinetics of not only MIBI but also TF is possibly useful for the evaluation of the severity of ischemia, and the Langendorff method and a methodological approach by continuous determinations of radioactivity may serve for the quantitative analysis of tracer kinetic profiles.

The Impact of Overnutrition on Insulin Metabolic Signaling in the Heart and the Kidney

“…PET imaging, using 18 F-deoxyglucose ( 18 FDG), is used to evaluate INS-stimulated glucose uptake (fig. 3) [41,45]. We have utilized magnetic resonance imaging in conditions of overnutrition and excessive tissue RAAS activation, and have demonstrated impaired/prolonged diastolic relaxation [7].…”

Fleming-Harrington Redistribution Wash-in Washout (FHRWW): The Platinum Standard for Nuclear Cardiology

“…Furthermore, comparisons of the initial 5-minute imaging with the 60-minute imaging demonstrated different results from the simple "uptake/retention" rest-stress model. Other investigators have noted similar differences between 5 minute and 60 minute imaging of the heart (Hurwitz 1993, Saha 1994, Giubbini 1995, Pace 2005) allowing for enhanced detection of congestive heart failure (Hurwitz 1998, Kumita 2002, Sugiura 2006, Matsuo 2007, cardiomyopathies (Meissner 2002, Ikawa 2007), Prinzmetal 's angina (Ono 2002(Ono , 2003 and underlying coronary artery disease (Meerdink 1990, Richter 1995, Shin 1995, Takeishi 1996, Takahashi 1996, Fujiwara 1998, Hurwitz 1998, Ayalew 2000, Liu 2001, Kumita 2002, Tanaka 2006, Fukushima 2007, VanBrocklin 2007 including evidence of wash-in (Meerdink 1990, Richter 1995 indicative of critical lesions not detected by conventional MPI. In the same way that thrombolysis in myocardial infarction (TIMI) flow is used to look for changes (sometimes subtle, sometimes not) in coronary blood flow in the catch lab, multiple imaging following pharmacologic or EST allows us to take a more advanced look at the physiologic function of the heart, unmasking ischemic heart disease missed by rest-stress imaging.…”

Accelerated BMIPP uptake immediately after reperfused ischemia in the isolated rat heart model

“…The radioactivity in the buffer was determined using a gamma-well counter (Well Counter Ò , ALOKA). The calibration factor for the radioactivity between the buffer and heart was determined as described [12].…”

“…Since flow in vessel should be constant due to continuous pump infusion (10 ml/min), K 1 was obviously defined as an extraction rate into myocardium. The principles and equation have been previously described [12].…”