2004 WHO Classification of the Renal Tumors of the Adults

López-Beltrán, Antonio; Scarpelli, Marina; Montironi, Rodolfo; Kirkali, Ziya

doi:10.1016/j.eururo.2005.11.035

Cited by 762 publications

(564 citation statements)

References 29 publications

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“…All patients were staged according to the 2002 TNM criteria [24], and nuclear grading was assigned according to criteria proposed by Fuhrman et al [25]. The histopathology was reviewed according to the 2004 World Health Organization (WHO) classification [26].…”

Section: Histopathologymentioning

confidence: 99%

Histopathologic Analysis of Peritumoral Pseudocapsule and Surgical Margin Status after Tumor Enucleation for Renal Cell Carcinoma

et al. 2009

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Section: Histopathologymentioning

confidence: 99%

Histopathologic Analysis of Peritumoral Pseudocapsule and Surgical Margin Status after Tumor Enucleation for Renal Cell Carcinoma

et al. 2009

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“…[1][2][3][4][5][6] It is currently defined by strict morphologic criteria according to the 2004 World Health Organization (WHO) classification of tumors. 1 Currently it is classified as a subtype of clear cell renal cell carcinoma; however, due to the excellent prognosis and distinct morphology debate exists regarding the nature of this tumor and whether it truly represents a variant of clear cell renal cell carcinoma.…”

mentioning

confidence: 99%

Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma

et al. 2010

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Multilocular cystic renal cell carcinoma is an uncommon low grade renal cell carcinoma with unique morphologic features. Its cytogenetic characteristics have not been fully investigated. Its relationship to typical clear cell renal cell carcinoma is uncertain. We evaluated 19 cases of multilocular cystic renal cell carcinoma diagnosed by strict morphologic criteria using the 2004 WHO classification system. The control group consisted of 19 low grade (Fuhrman grades 1 or 2) clear cell renal cell carcinomas. Chromosome 3p deletion status was determined by dual color interphase fluorescence in situ hybridization analysis. Chromosome 3p deletion was identified in 17 out of 19 (89%) of the clear cell renal cell carcinoma cases and 14 out of 19 (74%) of the multilocular cystic renal cell carcinoma cases, respectively. There was no difference in the status of chromosome 3p deletion between clear cell renal cell carcinoma and multilocular cystic renal cell carcinoma (P ¼ 0.40). These results support the concept that multilocular cystic renal cell carcinoma as a subtype of clear cell renal cell carcinoma.

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“…Renal cancer, a common neoplasm in Western Countries with more than 62,000 expected deaths in the USA in 2016 4 , is a complex disease with several distinct tumor subtypes 5, 6 . CCRCC is by far the most common renal cancer histological variant, accounting for 75 to 80% of renal neoplasms in adults 7 .…”

Section: The Contextmentioning

confidence: 99%

A divide-and-conquer strategy in tumor sampling enhances detection of intratumor heterogeneity in routine pathology: A modeling approach in clear cell renal cell carcinoma

López

Cortés

2016

F1000Res

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Intratumor heterogeneity (ITH) is an inherent process in cancer development which follows for most of the cases a branched pattern of evolution, with different cell clones evolving independently in space and time across different areas of the same tumor. The determination of ITH (in both spatial and temporal domains) is nowadays critical to enhance patient treatment and prognosis. Clear cell renal cell carcinoma (CCRCC) provides a good example of ITH. Sometimes the tumor is too big to be totally analyzed for ITH detection and pathologists decide which parts must be sampled for the analysis. For such a purpose, pathologists follow internationally accepted protocols. In light of the latest findings, however, current sampling protocols seem to be insufficient for detecting ITH with significant reliability. The arrival of new targeted therapies, some of them providing promising alternatives to improve patient survival, pushes the pathologist to obtain a truly representative sampling of tumor diversity in routine practice. How large this sampling must be and how this must be performed are unanswered questions so far. Here we present a very simple method for tumor sampling that enhances ITH detection without increasing costs. This method follows a divide-and-conquer (DAC) strategy, that is, rather than sampling a small number of large-size tumor-pieces as the routine protocol (RP) advises, we suggest sampling many small-size pieces along the tumor. We performed a computational modeling approach to show that the usefulness of the DAC strategy is twofold: first, we show that DAC outperforms RP with similar laboratory costs, and second, DAC is capable of performing similar to total tumor sampling (TTS) but, very remarkably, at a much lower cost. We thus provide new light to push forward a shift in the paradigm about how pathologists should sample tumors for achieving efficient ITH detection.

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2004 WHO Classification of the Renal Tumors of the Adults

Cited by 762 publications

References 29 publications

Histopathologic Analysis of Peritumoral Pseudocapsule and Surgical Margin Status after Tumor Enucleation for Renal Cell Carcinoma

Histopathologic Analysis of Peritumoral Pseudocapsule and Surgical Margin Status after Tumor Enucleation for Renal Cell Carcinoma

Multilocular cystic renal cell carcinoma is a subtype of clear cell renal cell carcinoma

A divide-and-conquer strategy in tumor sampling enhances detection of intratumor heterogeneity in routine pathology: A modeling approach in clear cell renal cell carcinoma

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