2-Vinyl-4H-1,3-Dithiin, a Bioavailable Compound from Garlic, Inhibits Vascular Smooth Muscle Cells Proliferation and Migration by Reducing Oxidative Stress

Torres‐Palazzolo, Carolina; Paola, Matilde de; Quesada, Isabel; Camargo, Alejandra Beatríz; Castro, Claudia

doi:10.1007/s11130-020-00819-x

Cited by 18 publications

(7 citation statements)

References 29 publications

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“…The vinyldithiins of garlic have significant implications in the regulation of cardiovascular diseases. An in vivo study on hypertensive rats reported that intake of 2-vinyl-4H-1,3-dithiine could provide significant protective effects against arterial remodelling in hypertension ( Torres-Palazzolo, de Paola, Quesada, Camargo, & Castro, 2020 ). In our current study, the level of 2-vinyl-4H-1,3-dithiine was very high in the BARI-3 variety which could be an excellent source of this promising compound for protection against hypertension in humans.…”

Section: Resultsmentioning

confidence: 99%

Bioactive properties and organosulfur compounds profiling of newly developed garlic varieties of Bangladesh

et al. 2023

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Section: Resultsmentioning

confidence: 99%

Bioactive properties and organosulfur compounds profiling of newly developed garlic varieties of Bangladesh

et al. 2023

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“…Glucosamine, as an amine sugar, has been reported to stimulate immune cells and mediate immune function by activating NF-κB, p38 and PKA pathways [ 58 ]. It was reported that 2VD could reduce intracellular ROS and increase total antioxidant status in vivo [ 59 ]. At 3 d post infection, metabolites of UDP-glucose and UDP-galactose were upregulated; both are crucial extracellular signaling molecules acting as potent agonists of extensively expressed P2Y14 receptor [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Multilayer omics reveals the molecular mechanism of early infection of Clonorchis sinensis juvenile

Deng

et al. 2023

Parasites Vectors

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Background Clonorchiasis remains a non-negligible global zoonosis, causing serious socioeconomic burdens in endemic areas. Clonorchis sinensis infection typically elicits Th1/Th2 mixed immune responses during the course of biliary injury and periductal fibrosis. However, the molecular mechanism by which C. sinensis juvenile initially infects the host remains poorly understood. Methods The BALB/c mouse model was established to study early infection (within 7 days) with C. sinensis juveniles. Liver pathology staining and observation as well as determination of biochemical enzymes, blood routine and cytokines in blood were conducted. Furthermore, analysis of liver transcriptome, proteome and metabolome changes was performed using multi-omics techniques. Statistical analyses were performed using Student's t-test. Results Histopathological analysis revealed that liver injury, characterized by collagen deposition and inflammatory cell infiltration, occurred as early as 24 h of infection. Blood indicators including ALT, AST, WBC, CRP and IL-6 indicated that both liver injury and systemic inflammation worsened as the infection progressed. Proteomic data showed that apoptosis and junction-related pathways were enriched within 3 days of infection, indicating the occurrence of liver injury. Furthermore, proteomic and transcriptomic analysis jointly verified that the detoxification and antioxidant defense system was activated by enrichment of glutathione metabolism and cytochrome P450-related pathways in response to acute liver injury. Proteomic-based GO analysis demonstrated that biological processes such as cell deformation, proliferation, migration and wound healing occurred in the liver during the early infection. Correspondingly, transcriptomic results showed significant enrichment of cell cycle pathway on day 3 and 7. In addition, the KEGG analysis of multi-omics data demonstrated that numerous pathways related to immunity, inflammation, tumorigenesis and metabolism were enriched in the liver. Besides, metabolomic screening identified several metabolites that could promote inflammation and hepatobiliary periductal fibrosis, such as CA7S. Conclusions This study revealed that acute inflammatory injury was rapidly triggered by initial infection by C. sinensis juveniles in the host, accompanied by the enrichment of detoxification, inflammation, fibrosis, tumor and metabolism-related pathways in the liver, which provides a new perspective for the early intervention and therapy of clonorchiasis. Graphical Abstract

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“…Moreover, 2-vinyl-4H-1,3-dithiin, an organosulfur compound found in macerated garlic oil or in stir-fried garlic, decreased spontaneously hypertensive rat’s vascular smooth muscle cells proliferation and cell migration and arrested cell cycle at G2 phase. Furthermore, it decreased reactive oxygen species production induced by angiotensin II [ 157 ]. Also, diallyl disulphide and diallyl trisulphide have been reported for their capacity to induce neovasculogenesis via PI3K/Akt pathway activation [ 68 , 141 ].…”

Section: Importance Of Allioideae Species In Cardiovascular Diseasesmentioning

confidence: 99%

Natural Products in Cardiovascular Diseases: The Potential of Plants from the Allioideae Subfamily (Ex-Alliaceae Family) and Their Sulphur-Containing Compounds

Alves-Silva

Zuzarte

Girão

et al. 2022

Plants

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Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and, together with associated risk factors such as diabetes, hypertension, and dyslipidaemia, greatly impact patients’ quality of life and health care systems. This burden can be alleviated by fomenting lifestyle modifications and/or resorting to pharmacological approaches. However, due to several side effects, current therapies show low patient compliance, thus compromising their efficacy and enforcing the need to develop more amenable preventive/therapeutic strategies. In this scenario, medicinal and aromatic plants are a potential source of new effective agents. Specifically, plants from the Allioideae subfamily (formerly Alliaceae family), particularly those from the genus Allium and Tulbaghia, have been extensively used in traditional medicine for the management of several CVDs and associated risk factors, mainly due to the presence of sulphur-containing compounds. Bearing in mind this potential, the present review aims to gather information on traditional uses ascribed to these genera and provide an updated compilation of in vitro and in vivo studies validating these claims as well as clinical trials carried out in the context of CVDs. Furthermore, the effect of isolated sulphur-containing compounds is presented, and whenever possible, the relation between composition and activity and the mechanisms underlying the beneficial effects are pointed out.

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2-Vinyl-4H-1,3-Dithiin, a Bioavailable Compound from Garlic, Inhibits Vascular Smooth Muscle Cells Proliferation and Migration by Reducing Oxidative Stress

Cited by 18 publications

References 29 publications

Bioactive properties and organosulfur compounds profiling of newly developed garlic varieties of Bangladesh

Bioactive properties and organosulfur compounds profiling of newly developed garlic varieties of Bangladesh

Multilayer omics reveals the molecular mechanism of early infection of Clonorchis sinensis juvenile

Natural Products in Cardiovascular Diseases: The Potential of Plants from the Allioideae Subfamily (Ex-Alliaceae Family) and Their Sulphur-Containing Compounds

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