2-Thienyl-4-furyl-6-aryl pyridine derivatives: Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure–activity relationship study

Synthesis and antiproliferative activity of novel symmetrical alkylthio- and alkylseleno-imidocarbamates

“…Among the many moieties identified, the following are included in our series of chemical structures: furyl [33,34], thienyl [35,36], isoxazole [37,38], benzothiophene [39], benzodioxole [40], quinoline [41,42], phenylquinoline [43,44] and acridine [45,46].…”

Synthesis and characterization of new 3,5-disubstituted-4,5-dihydro-1H-pyrazole and their carbothioamide derivatives

“…Although chalcones 1, 3-5 have been reported previously [44][45][46][47], their pyrazoles 6-10 and their carbothioamide derivatives 11-14 have not been reported in the literature.…”

2-Amino-3-cyanopyridine derivatives as carbonic anhydrase inhibitors

“…Among these, cyanopryridines and aminocyanopyridines substituted with different alkyl and aryl groups 5 were found to have antimicrobial 24 , anti-inflammatory, analgesic and antipyretic properties 25 . 2-Thienyl-4-furyl-pyridine and 2-thienyl-4-furyl-6-aryl pyridine derivatives exhibited strong inhibitory activity against the nuclear enzymes topoisomerase I and II and inhibitory activities and cytotoxicity against several human cancer cell lines 26 . These compounds are also valuable intermediates in the syntheses of a variety of biologically active heterocyclic compounds 27 .…”