2-Pyrazol-1-yl-thiazole derivatives as novel highly potent antibacterials

Convenient Multicomponent One‐Pot Synthesis of 2‐Iminothiazolines and 2‐Aminothiazoles Using Elemental Sulfur Under Aqueous Conditions

“…2-Iminothiazolines are biologically active compounds represented by selective cannabinoid receptor type 2 (CB2) agonists, [1][2][3][4] carbonic anhydrase (CA), cyclooxygenase (COX) and lipoxygenase (LOX) inhibitors, [5][6][7][8][9] anticancer [10,11] and antithrombotic agents, [12] HIV1 reverse transcriptase inhibitors [13] and fungicides (Figure 1). [14] Similarly, related 2-aminothiazoles showed anticancer, [15][16][17][18] antibacterial, [19] anticonvulsant, antidiabetic, antihypertensive, anti-inflammatory, antiviral, antimicrobial and neuroprotective activities. [20] They are represented by the marketed antiviral and antiparasitic drug Nitazoxanide, the β3 adrenergic receptor agonist Mirabegron, the antileukemic Dasatinib and the antiulcer Famotidine (Figure 1).…”