Overview on Biological Activities of Thiazole Derivatives

Gujjarappa, Raghuram; Kabi, Arup K.; Sravani, Sattu; Garg, Aakriti; Vodnala, Nagaraju; Tyagi, Ujjawal; Kaldhi, Dhananjaya; Gupta, Shikhar; Malakar, Chandi C.

doi:10.1007/978-981-16-8399-2_5

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2023

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“…Among the wide variety of nitrogen-and sulfurcontaining heterocyclic compounds, thiazoles are of paramount importance because of their broad-spectrum biological activity [1][2][3]. In particular, evaluation of the anticancer activity of thiazole derivatives revealed a lead compound exhibiting cytotoxic properties against many cancer cell lines and exceeding that of reference drug 5-fluorouracil.…”

Section: Introductionmentioning

confidence: 99%

One‐pot regioselective synthesis of new imidazo[4,5‐e]thiazolo[3,2‐b][1,2,4]triazines by reaction of imidazotriazines with propargyl bromide

Vinogradova

Кравченко

Газиева

2023

Journal of Heterocyclic Chem

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A regioselective one‐pot method for the synthesis of imidazo[4,5‐e]thiazolo[3,2‐b][1,2,4]triazine derivatives has been developed by the reaction of imidazotriazinethiones with propargyl bromides upon treatment with potassium carbonate in methanol. The synthesis was accomplished by converting the imidazotriazinethiones into S‐propargyl derivatives followed by subsequent 5‐exo‐dig cyclization. The mechanism of the cyclization was studied using deuterium labels.

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Section: Introductionmentioning

confidence: 99%