2-Oxo-1,8-naphthyridine-3-carboxylic acid derivatives with potent gastric antisecretory properties

Santilli, Arthur A.; Scotese, Anthony C.; Bauer, R. F.; Bell, Stanley C.

doi:10.1021/jm00395a015

Cited by 65 publications

(34 citation statements)

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“…These compounds were evaluated by Santilli et al [169] in the pyloric-ligated (Shay) rat model. Active compounds were 4-amino-1-ethyl-1,2-dihydro-2-oxonaphthyridine-3-carboxylic acid ethyl ester (105) and 1-ethyl-1,2-dihydro-7-methyl-4-(4-methyl-1-piperazinyl)-2-oxo-1,8-naphthyridine-3-carboxylic acid ethyl ester, which lowered total acid output in the rat in a dose-related fashion.…”

Section: Antimalarial Propertiesmentioning

confidence: 99%

1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

Madaan

Verma

Kumar

et al. 2015

Archiv der Pharmazie

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The 1,8-naphthyridine group of compounds have gained special attention of researchers on account of their demonstrating a variety of interesting biological activities. A wide range of biological properties establishes them as potent scaffolds in therapeutic and medicinal research. The broad spectrum of activities primarily includes antimicrobial, antiviral, anticancer, anti-inflammatory, and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer's disease, multiple sclerosis, and depression. In addition, these synthetic derivatives have been found to possess activities such as anti-osteoporotic (α(v)β(3) antagonists), anti-allergic, antimalarial, gastric antisecretory, bronchodilator, anticonvulsant, anti-hypertensive, platelet aggregation inhibition, anti-oxidant, EGFR inhibition, protein kinase inhibition, ionotropic agent, β-3 antagonist, MDR modulator, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities. In spite of the widespread application of the 1,8-naphythyridine scaffolds, only a limited number of review articles are available till date. In this review, we attempt to compile and discuss the key data available in the literature for the multiple biological activities of 1,8-naphthyridine derivatives, in a chronological manner. This review compilation (with 199 references) may be helpful in understanding the diverse biological properties of 1,8-naphthyridines and provide insights into their mechanism of action. This may direct future research in the synthesis of new derivatives and exploring this scaffold for other possible biological activities.

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Section: Antimalarial Propertiesmentioning

confidence: 99%

1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

Madaan

Verma

Kumar

et al. 2015

Archiv der Pharmazie

View full text Add to dashboard Cite

show abstract

“…The first naphthyridine derivatives were prepared in 1893 by Reissert who suggested the name naphthyridine [5]. From literature it was also noted that 1,8-naphthyridine derivatives were not only use as luminescence materials in molecular recognition because of their rigid planer structure [6][7][8], possess antibacterial [9], antymicobacterial [10], antitumoral [11], anti-inflammatory [12], antiplatelet [13], gastric antisecretary [14], antiallergic [15] and local anaesthetic [16]. Recently, our research group reported systematic studies about the fluorescence properties of differently substituted pyrazolofused heterocycles [17][18][19][20][21][22] and benzo naphthyridines [23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

An efficient Synthesis and Photophysical Properties of 1H-pyrazolo-[3,4-b]pyridine and pyrazolo[3,4-b][1,8]naphthyridines

2015

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A novel synthon 6-amino-3-(4-methoxyphenyl)-1-phenyl-1H-pyrazolo[3,4-b] pyridine-5-carbaldehyde 4 was synthesized by multistep process. Then Friedlander condensation of this synthon with reactive methylenes was performed to achieve interesting tricyclic 6a-b, tetracyclic 6d and pentacyclic 6c N-heterocycles in excellent yield. The absorption and emission spectra of compounds 1-4 and 6 were measured and observed that the absorption and emission depends on the substituent at C-6 and C-7 position of pyridine ring in naphthyridines skeleton 6.

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“…A survey of the literature shows that the major synthetic approaches that are used to prepare various types of 1,8-naphthyridine system involves condensation of 2-aminopyridine derivatives with carbonyl compounds containing an activated methylene group [10][11][12][13][14][15][16] or with β-ketoesters [17]. Another general procedure for the preparation of 1,8-naphthyridine condensed ethanolic 2-amino-3-formylpyridines, in the presence piperidine base, with active methylene compounds, aldehydes, acyclic and cyclic ketones or diketones [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%