1,8‐Naphthyridine Derivatives: A Review of Multiple Biological Activities

Abstract

The 1,8-naphthyridine group of compounds have gained special attention of researchers on account of their demonstrating a variety of interesting biological activities. A wide range of biological properties establishes them as potent scaffolds in therapeutic and medicinal research. The broad spectrum of activities primarily includes antimicrobial, antiviral, anticancer, anti-inflammatory, and analgesic activities. 1,8-Naphthyridine derivatives have also exhibited potential applications in neurological disorders such as Alzheimer's disease, multiple sclerosis, and depression. In addition, these synthetic derivatives have been found to possess activities such as anti-osteoporotic (α(v)β(3) antagonists), anti-allergic, antimalarial, gastric antisecretory, bronchodilator, anticonvulsant, anti-hypertensive, platelet aggregation inhibition, anti-oxidant, EGFR inhibition, protein kinase inhibition, ionotropic agent, β-3 antagonist, MDR modulator, adenosine receptor agonist, adrenoceptor antagonist, and pesticide activities. In spite of the widespread application of the 1,8-naphythyridine scaffolds, only a limited number of review articles are available till date. In this review, we attempt to compile and discuss the key data available in the literature for the multiple biological activities of 1,8-naphthyridine derivatives, in a chronological manner. This review compilation (with 199 references) may be helpful in understanding the diverse biological properties of 1,8-naphthyridines and provide insights into their mechanism of action. This may direct future research in the synthesis of new derivatives and exploring this scaffold for other possible biological activities.

Novel 1,8-Naphthyridine Derivatives: Design, Synthesis and in vitro screening of their cytotoxic activity against MCF7 cell line

“…Certain 1,8-naphthyridine derivatives are considered good DNA intercalators. They bind with double stranded DNA (ds-DNA) by intercalating between adjacent base pairs, thus changing the DNA conformation and inhibit DNA duplication or transcription leading to suppression of cancer cell growth [15][16][17]. Due to their wide range of biological effects, 1,8-naphthyridine derivatives have been considered promising antitumor agents [18][19][20].…”

Recent Developments and Multiple Biological Activities Available With 1, 8-Naphthyridine Derivatives: A Review

“…Recently, there are significant numbers of reviews which have been published related to the chemistry, synthesis and biological activity of 1, 8-naphthyridine and bioactivities of the 1, 8-naphthyridine metal complexes and multiple activities of 1, 8-naphthyridine [131].…”

Expeditious Sonochemical Synthesis of New 1,8-Naphthyridine Derivatives and their Inhibitory Activity on HepG2 Cell Line

“…Despite the tremendous efforts made in discovering and developing innovative anticancer drugs, it still holds the record for being one of the most common leading causes of death worldwide. 1,8-Naphthyridine derivatives' anticancer properties earned exceptional recognition by researchers, a number of their derivatives were explored as antitumor agents [1][2][3][4][5][6][7]. The highly significant and best explored derivative of 1,8-naphthyridine as anticancer is voreloxin, SNS-595(+)-1,4-dihydro-7-(trans-3-methoxy-4 methylamino-1-pyrrolidinyl)-4oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic acid Fig.…”