2–Methylpyridinium 2,6-Dioxo-5-(2,4,6–Trinitrophenyl)–1,2,3,6-Tetrahydropyrimidin–4–Olate: Synthesis, Characterization, Single Crystal X-ray Analysis and Evaluation of Anticonvulsant/Hypnotic activity and Toxicity Effects

Isoquinolinium 5-(2,4-dinitrophenyl)-1,3-dimethyl-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-olate: crystal structure, Hirshfeld surface analysis and pharmacological evaluation

“…The isoquinoline unit also displays a wide spectrum of activity and it is an important component of many biologically active alkaloids (Montalban, 2011). Since 2008, we have been periodically synthesizing new barbiturate derivatives and exploring their anticonvulsant activity (Kalaivani et al, 2008;Kalaivani & Malarvizhi, 2009;Kalaivani & Buvaneswari, 2010;Manickkam & Kalaivani, 2011;Babykala & Kalaivani, 2012;Buvaneswari & Kalaivani, 2013;Vaduganathan & Doraisamyraja, 2014;Gomathi & Kalaivani, 2015). The title molecular salt, which is a new derivative of 1,3dimethylbarbituric acid (barbiturate), was recently obtained by our group.…”

Crystal structure of 3-methylpyridinium picrate: a triclinic polymorph

“…They reported the crystal structure of the monoclinic polymorph of the title molecular salt: space group P2 1 /n. The observation that the presence of more than one heterocyclic component in a molecule enhances the biological response and thermal stability encouraged us to synthesize several new carbon-bonded anionic sigma complexes from chloronitro-aromatic compounds and pyrimidine derivatives in the presence of pyridine bases (Babykala et al, 2014;Buvaneswari & Kalaivani, 2013;Mangaiyarkarasi & Kalaivani, 2013;Manickkam & Kalaivani, 2011Sridevi & Kalaivani, 2012). Surprisingly, when we made an attempt to synthesize a similar type of complex from the electrondeficient chloronitroaromatic compound (picryl chloride), an imidazole derivative (hydantoin) and 3-methylpyridine, the title salt crystallized from the medium (ethanol) instead of the expected carbon-bonded anionic sigma complex.…”

Syntheses, structures, catalytic and antitumor activities of a series of pyrimidine derivatives coordination complexes

“…As the previous studies reported, pyrimidine compounds could also be used as chemotherapeutic agents and hypnotic drugs for the nervous system [28][29][30][31][32][33]. In addition, during 1970s, Rosenberg found platinum pyrimidine compounds have anticancer activity, as a new class of potent antitumour agents, which opened up a new direction for cancer drug research [34].…”