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A Z‐scheme heterojunction with high electron–hole pairs separation efficacy and enhanced redox potentials exhibits tremendous potential in photonic theranostics, but still remains unexplored and challenging. Herein, novel 2D thermally oxidized pyrite nanosheets (TOPY NSs) with FeS2 core and Fe2O3 shell are fabricated combining ball grinding and two‐step probe sonication assisted liquid exfoliation under different solution and air environments. The Fe2O3 shell and Fe3+/Fe2+ inside TOPY NSs can both damage the tumor microenvironment through glutathione consumption and O2 production, and produce ·OH by Fenton reaction. More interestingly, a direct Z‐scheme heterojunction based on FeS2 core and Fe2O3 shell is constructed, in which the electrons in the conduction band (CB) of Fe2O3 are recombined with the holes in the valence band (VB) of FeS2, leaving stronger reduction/oxidation potentials in the CB of FeS2 and the VB of Fe2O3. Under irradiation of a 650 nm laser, the generation of ·O2− from O2 and ·OH from OH− on the CB of FeS2 and VB of Fe2O3, respectively, is largely enhanced. Furthermore, the NSs can be triggered by an 808 nm laser to generate local hyperthermia for photothermal therapy. Moreover, the fluorescent, photoacoustic, and photothermal imaging capabilities of the NSs allow multimodal imaging‐guided cancer treatment.

Abstract-Game-based learning pedagogy has received widespread attention in recent years due to its conceivable potential in adapting to the evolving needs from the "Net Generation", or "digital natives". Due to difficulties in defining, constructing and measuring complex variables as well as the subsequent results, however, rigorous empirical research on the effectiveness of gamification in education or game-based learning has been limited, especially in tertiary education.In this research, we investigate the effectiveness of game-based learning as an instructional strategy for tertiary education. Particularly, we conducted a semi-structured survey in a finance class, where an online stock trading game was implemented. Based on the data retrieved from the survey, we are able to compare simulation game with traditional learning methods in terms of subjective effectiveness, difficulty and student preference. We find evidence that game-based learning is more effective, easier to grasp, and more preferred by students than traditional learning methods. We also find evidence that extrinsic motivation (e.g., monetary incentives) affect the effectiveness of gamification in higher education, consistent with existing literature.

Cancer recurrence and metastasis are still common causes of postsurgery death in patients with solid tumors, suggesting that additional consolidation therapeutic strategies are necessary. We have previously found that oxaliplatin (OXA) treatment causes further up-regulation of CD155, which is abundantly expressed in tumors for resulting in increased sensitivity of cancer to anti-CD155 therapy. Here, we report O-TPNVs, which are TIGIT-expressing cell membrane and platelet cell membrane fusion nanovesicles (TPNVs) loaded with OXA. Platelet-derived membrane components enable O-TPNVs to target postsurgery wounds and interact with circulating tumor cells (CTCs). OXA directly kills residual tumor cells and CTCs, induces immunogenic cell death, and activates the immune system. TPNVs bind to CD155 on tumor cells, block the CD155/TIGIT pathway, and restore CD8 + T cell activity. In vivo analyses reveal that O-TPNVs achieve synergistic chemotherapeutic and immunotherapeutic effects, effectively inhibiting the recurrence and metastasis of triple-negative breast cancer (4T1) after surgery.