2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one

Arulmurugan, Subramaniyan; Kavitha, Helen P.

doi:10.3390/m695

Cited by 6 publications

(3 citation statements)

References 15 publications

(15 reference statements)

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“…A novel series of tetrazole compounds were reported to possess antimicrobial activity in vitro by the disc diffusion method measuring zones of inhibition. The results of the study showed that the synthesized compound 2-methyl-3-{4-[2-(1 H -tetrazol-5-yl-ethylamino]phenyl}-3 H -quinazolin-4-one ( 24 ) displayed fairly good antimicrobial activity against the test organisms, although the activity was less than that of the reference drugs (ciprofloxacin and fluconazole, respectively) [ 41 ]. It was reported that a series of new 5-thio-substituted tetrazole derivatives were synthesized and antimicrobial screening showed that all the synthesized compounds showed moderate activity against the tested organisms.…”

Section: Biological Activity Of Tetrazolium Derivativesmentioning

confidence: 99%

Tetrazolium Compounds: Synthesis and Applications in Medicine

2015

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Tetrazoles represent a class of five-membered heterocyclic compounds with polynitrogen electron-rich planar structural features. This special structure makes tetrazole derivatives useful drugs, explosives, and other functional materials with a wide range of applications in many fields of medicine, agriculture, material science, etc. Based on our research works on azoles and other references in recent years, this review covers reported work on the synthesis and biological activities of tetrazole derivatives.

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Section: Biological Activity Of Tetrazolium Derivativesmentioning

confidence: 99%

Tetrazolium Compounds: Synthesis and Applications in Medicine

2015

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“…Compounds 3-(4-(2-methyl-4-oxoquinazolin-3(4H)-yl)phenylamino)propanenitrile (1), 3,3'-(4,4'-sulfonylbis(4,1-phenylene)bis(azanediyl))dipropanenitrile (6), 3,3'-(6-phenyl--1,3,5-triazine-2,4-diyl)bis(azanediyl)dipropanenitrile (12) and 3,3,3',1,3,5-triazine-2,4,6--triyl)tris(azanediyl)tripropanenitrile (18) were prepared from primary amine by treatment with acrylonitrile and Triton B following reported literature (9).…”

Section: Methodsmentioning

confidence: 99%

Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles

Arulmurugan¹,

Kavitha²

2013

Acta Pharmaceutica

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2 The present work deals with the synthesis of some novel heterocyclic compounds such as benzoxazoles , 7, 13 and 19, imidazoles 3, 8, 14 and 20, benzimidazoles 4, 9, 15 and 21, and tetrazoles 10, 16, and 22. The synthesized compounds were characterized by IR, 1H NMR, mass spectrometry and elemental analysis. The compounds were evaluated for cytotoxicity against human cancer cell lines such as MCF-7 (breast cancer) and HT-29 (colon cancer) by the MTT assay method. Among the tested compounds, 4,4’-sulfonylbis(N-(2-(1H-benzo[d]imidazol- -2-yl)ethyl)aniline (9), N-bis(2-(benzo[d]oxazol-2-yl)-ethyl)- 6-phenyl-1,3,5-triazine-2,4-diamine (13), N-bis(2-(1H-benzo[ d]imidazol-2-yl)ethyl)-6-phenyl-1,3,5-triazine-2,4-diamine (15) and N-tris(2-1H-benzo[d]imidazol-2-yl)ethyl)- 1,3,5-triazine-2,4,6-triamine (21) showed potent cytotoxicity.

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“…Heterocyclic compounds have a great deal of attention because of their biological activity and also they make possible development of novel material with unique properties (Mostafa, 2010;Arulmurugan and Kavitha, 2010;Srinivas and Kumar, 2010;Caiazzo et al, 2004). One very interesting and promising class of heterocyclic is the series of 2,5-disubstituted-1,3,4oxadiazoles that have been proven to be effective antimicrobial, anti-inflammatory, fungicidal and bactericidal agents (Sharma et al, 2010;Narasimhan et al,2010;Banday et al, 2010;Dewangan et al, 2010;Bari et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

The Use of 3-Benzylidene Phthalide as Precursor to Synthesize New 1,3,4-Oxadiazole Derivatives

Younis¹

2011

RJS

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A series of new 2,5-disubstituted 1,3,4-oxadiazoles represented by compounds 2-phenyl-1-(2-(5-(5-aryl-1,3,4-oxadiazol-2-yl amino)-4H-1,2,4-triazol-3-yl)phenyl)ethanone (5a-f) have been synthesized from(Z)-3-benzylidene phthalide as useful precursor. 3-Benzylidene phthalide was reacted, firstly with urea under microwave irradiation and dry conditions to afford the corresponding 1-(2-(α-phenylacetyl)benzoyl)urea (1). The later compound underwent cycloaddition reaction with hydrazine hydrate (80%) to give 1-(2-(5-amino-4H-1,2,4-triazol-3yl)phenyl)-2-phenylethanone (2), which upon reaction with ethyl chloroformate provided the corresponding ethyl-5-(2-(α-phenylacetyl)phenyl)-4H-1,2,4-triazol-3-yl carbamate (3). 4-(5-(2-(α-Phenylacetyl)phenyl)-4H-1,2,4-triazol-3-yl) semicarbazide (4) was also prepared from the reaction of compound (3) with hydrazine hydrate (80%) under mild conditions. Finally, 2-phenyl-1-(2-(5-(5-aryl-1,3,4-oxadiazol-2-yl amino)-4H-1,2,4-triazole-3-yl)phenyl) ethanone (5a-f) were obtained via the reaction of compound (4) with various substituted benzoic acid by the action of phosphorous oxychloride. The structure of the prepared compounds were confirmed by the available physical and spectral methods.

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2-Methyl-3-{4-[2-(1H-tetrazol-5-yl)ethylamino]phenyl}-3H-quinazolin-4-one

Cited by 6 publications

References 15 publications

Tetrazolium Compounds: Synthesis and Applications in Medicine

Tetrazolium Compounds: Synthesis and Applications in Medicine

Synthesis and potential cytotoxic activity of some new benzoxazoles, imidazoles, benzimidazoles and tetrazoles

The Use of 3-Benzylidene Phthalide as Precursor to Synthesize New 1,3,4-Oxadiazole Derivatives

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