2′-Chloro-4-methoxy-3-nitrobenzil

Nithya, G; Thanuja, B.; Chakkaravarthi, G.; Kanagam, Charles C.

doi:10.1107/s1600536811019532

Cited by 3 publications

(1 citation statement)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…By this technique, it is also possible to find a new drug and also prepare new synthetic compounds and lead molecules with different mechanisms and thereby different target organisms, especially against drugresistant bacteria and emerging microbes. For the purpose, three different substituted benzil compounds have been synthesized, characterized, and evaluated their capabilities in biological activity [14][15][16][17][18][19][20][21][22][23]. From the literature survey, it had been found that benzil has antitumor activity [24].…”

Section: Introductionmentioning

confidence: 99%

Biological Activity and Molecular Docking of 2’-Bromo-4-Methoxy-3-Nitro Benzil, 2,2’-Dibromo Benzil, and 4,4’-Dichloro Benzil

Nithya

Ramasamy

Kanakam

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

Objective: A series of benzil compounds have been synthesized by oxidation of corresponding benzoins which in turn were prepared from respective aldehydes. Using this protocol, three new benzils were prepared in good-to-excellent yields and their biological activity has been delineated. Methods:Molecular docking studies were conducted to validate the obtained pharmacological data and to provide understandable evidence for the observed antimicrobial activity of all synthesized compounds. Several benzils exhibited excellent antimicrobial and cytotoxic activity. To determine the cytotoxic effects, we used an MTT viability assay. Results:The results showed that cell growth is significantly lower in extract-treated cells compared to untreated control. The effect of inhibition of cell growth was shown in different concentration dosages for cytotoxic, antibacterial, and antioxidant activity in vitro. Discussion:The antimicrobial activity results indicated that some of the tested compounds showed the most promising antibacterial activities. These observations may promote a further development of our research in this field. The antioxidant activity was also performed for the compound benzil and its substituted analogs.

show abstract

Section: Introductionmentioning

confidence: 99%

Biological Activity and Molecular Docking of 2’-Bromo-4-Methoxy-3-Nitro Benzil, 2,2’-Dibromo Benzil, and 4,4’-Dichloro Benzil

Nithya

Ramasamy

Kanakam

2018

Asian J Pharm Clin Res

View full text Add to dashboard Cite

show abstract

XRD, CHNSO, fluorescence, filter-influx, NLO, photoconductivity, hardness and helical spring-fabricated device stress analysis of 2′-chloro-4-methoxy-3-nitrobenzil (CMNB) crystal of different scalings for opto-electronic filter and band gap engineering utilities

Kolanjinathan¹,

Hariharasuthan²,

Sivaramakrishnan

et al. 2021

J Mater Sci: Mater Electron

View full text Add to dashboard Cite

Study of intermolecular interactions in binary mixtures of 2′-chloro-4-methoxy-3-nitro benzil in various solvents and at different concentrations by the measurement of acoustic properties

Nithya¹,

Thanuja²,

Kanagam³

2013

Ultrasonics Sonochemistry

View full text Add to dashboard Cite

Density (ρ), ultrasonic velocity (u), adiabatic compressibility (β), apparent molar volume (Ø), acoustic impedance (Z), intermolecular free length (L(f)), relative association (RA) of binary mixtures of 2'-chloro-4-methoxy-3-nitro benzil (abbreviated as 2CBe) in ethanol, acetonitrile, chloroform, dioxane and benzene were measured at different concentrations at 298 K. Several useful parameters such as excess density, excess ultrasonic velocity, excess adiabatic compressibility, excess apparent molar volume, excess acoustic impedance and excess intermolecular free length have been calculated. These parameters are used to explain the nature of intermolecular interactions taking place in the binary mixture. The above study is useful in understanding the solute--solvent interactions occurring in different concentrations at room temperature.

show abstract

2′-Chloro-4-methoxy-3-nitrobenzil

Abstract: In the title compound, C15H10ClNO5, the dihedral angle between the aromatic rings is 87.99 (5)°. The O—C—C—O torsion angle between the two carbonyl units is −119.03 (16)°. The crystal structure is stabilized by a weak intermolecular C—H⋯O hydrogen bond.

Cited by 3 publications

References 8 publications

Biological Activity and Molecular Docking of 2’-Bromo-4-Methoxy-3-Nitro Benzil, 2,2’-Dibromo Benzil, and 4,4’-Dichloro Benzil

Biological Activity and Molecular Docking of 2’-Bromo-4-Methoxy-3-Nitro Benzil, 2,2’-Dibromo Benzil, and 4,4’-Dichloro Benzil

XRD, CHNSO, fluorescence, filter-influx, NLO, photoconductivity, hardness and helical spring-fabricated device stress analysis of 2′-chloro-4-methoxy-3-nitrobenzil (CMNB) crystal of different scalings for opto-electronic filter and band gap engineering utilities

Study of intermolecular interactions in binary mixtures of 2′-chloro-4-methoxy-3-nitro benzil in various solvents and at different concentrations by the measurement of acoustic properties

Contact Info

Product

Resources

About