2-Chloro-1-(2,4,5-trichlorophenyl)vinyl Dimethyl Phosphate, a New Insecticide with Low Toxicity to Mammals

Degradation of tetrachlorvinphos and its major metabolite 2,4,5-trichlorophenacyl chloride in aqueous media

“…Analytically pure tetrachlorvinphos was prepared by the procedure described by Whetstone et al (1966). All solvents were of pesticide grade and used as received.…”

The metabolism and degradation of vinyl phosphate insecticides

“…The technical product contains a minimum of 94 percent w of tetrachlorvinphos. Some of the physical properties of the compound are summarised in Table X. Tetrachlorvinphos is an effective foliar insecticide and is active particularly against the adult and larval forms of lepidopterous pests (WHETSTONE et al 1966). It can be applied to a wide range of crops including fruits, vegetables, maize, rice, and cotton, as wen as forage crops.…”

“…It exhibits a very low order or mammalian toxieity to laboratory test animals (WHETSTONE et al 1966, WALKER et al 1972) and the LD50 values (aeute oral) are for the male rat 4,000 to 5,000 mg./kg. and for the male mouse >5,000 mg./kg.…”

“…In view of the similarities in the anticholinesterase properties of chlorfenvinphos and tetrachlorvinphos (WHETSTONE et al 1966) and the similar metabolie fate of the two compounds, the difIerence in toxicity to the rat is interesting. There is apparently no significant difIerence between plasma protein bindings of the two compounds (BoYER 1967).…”

“…There is apparently no significant difIerence between plasma protein bindings of the two compounds (BoYER 1967). WHETSTONE et al (1966) have suggested that the poor solubility and partition properties of tetrachlorvinphos may limit its penetration and translocation in mammals, thus preventing the development of locally high, biologically active concentrations. However, metabolism studies clearly show that the poor solubility properties do not lead to persistence of the compound in mammals.…”