Degradation of tetrachlorvinphos and its major metabolite 2,4,5-trichlorophenacyl chloride in aqueous media

Abstract

AKHTARterial. Since compounds 3 and 7 were also isolated from the [rir~g-'~C]fonofos standard solutions, the question of their metabolic formation cannot be answered at this time. Compound 4, which is directly formed from compound 3, is probably not formed from fonofos (compound 1).

Effect of pH and Cooking Temperature on the Stability of Organophosphate Pesticides in Beef Muscle

“…The stability of stirofos to acid hydrolysis noted in our investigation was reported previously. Akhtar (1977) studied the effects of various pHs on the stability of the insecticide stirofos and its metabolite 2,4,5-trichlorophenacyl chloride in aqueous media. Although the study found the compound to hydrolyze in both acidic and alkaline media, the half-life of its hydrolytic degradation was larger at pH 5.75 than at pH 6.5.…”

“…Acidand base-catalyzed oxidative and hydrolytic decompositions of parent OPs also have been studied. Akhtar (1977) investigated the degradation of the insecticide stirofos in buffered aqueous media at pH 5.75, 6.5, 7.4, 8.0, and 9.0. This research showed that the insecticide was hydrolyzed progressively as pH increased.…”

Study of the mechanism of Flavobacterium sp. for hydrolyzing organophosphate pesticides

“…The analytical procedure was established and validated for each pesticide. Additionally, metabolites of tetrachlorovinphos were identified and quantified according to their fragmentation pattern [10,11] while paranitrophenol was quantified colorimetrically as a metabolite of methyl‐parathion as described elsewhere [8], considering that one mole of paranitrophenol is produced per mole of hydrolyzed methyl‐parathion.…”

“…PTE proposed herein was based on X‐ray data previously described elsewhere [15], on data regarding chemical and enzymatic hydrolysis of methylparathion [8] and tetrachlorvinphos [10,11], and on findings of the QSAR analysis of the present study.…”

Metabolism and excretion of tetrachlorvinphos in dairy cows

“…Pesticide and reagent grade solvents were used. Analytically pure samples of tetrachlorvinphos (I), desmethyl tetrachlorvinphos (II), 2,4,54richlorophenacyl chloride (III), (2,4,5-trichlorophenyl)acetophenone (IV), 1-(2,4,5-trichlorophenyl)ethanol (V), 2-chloro-1-(2,4,5-trichloropheny1)ethanol (VI), (2,4,Btrichlorophenyl)ethane-1,2-diol (VII), 2,4,5-trichloromandelic acid (VIII), and 2,4,5-trichlorophenacyl alcohol were available from previous studies (Akhtar, 1977;Akhtar and Foster, 1977). Bovine liver @-glucuronidase (500 units/mL) was obtained from Sigma Chemical Co., St. Louis, MO.…”