2020
DOI: 10.1016/j.bioorg.2020.104170
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2-Aryl benzazole derived new class of anti-tubercular compounds: Endowed to eradicate mycobacterium tuberculosis in replicating and non-replicating forms

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Cited by 6 publications
(3 citation statements)
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“…In M. tuberculosis , DMK is a precursor in MK biosynthesis. Interestingly, small molecule inhibitors of MenG, the enzyme that converts DMK into MK, were bactericidal in M. tuberculosis 33,44 . This substantiates the inability of Mtbd to turn over DMK and highlights the tight redox control between the quinone pool and Mtbd .…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…In M. tuberculosis , DMK is a precursor in MK biosynthesis. Interestingly, small molecule inhibitors of MenG, the enzyme that converts DMK into MK, were bactericidal in M. tuberculosis 33,44 . This substantiates the inability of Mtbd to turn over DMK and highlights the tight redox control between the quinone pool and Mtbd .…”
Section: Discussionmentioning
confidence: 99%
“…Mtbd is characterized by a unique disulfide bond that was hypothesized to reduce the flexibility of the substrate binding Q-loop (Fig 5A ) and thereby confer a regulatory role for enzyme activity 12,33 . Previous studies faced limitations examining this mechanism, as they relied on chemical reductants such as DTT to reduce the quinone pool, which inadvertently affects the disulfide bond itself.…”
Section: Mtbd Activity Is Regulated By a Unique Q-loop Disulfide Bondmentioning
confidence: 99%
“…Velappan and co-workers synthesized 2-aryl benzothiazole based dual targeted compounds 118a–d , 120a , 123a–d through the reaction of 2-amino thio phenol 1 with various heterocyclic derivatives (Scheme 32, Table 26). 69…”
Section: Recent Synthesis Of Benzothiazole Based Anti-tubercular Mole...mentioning
confidence: 99%