2-Amino-5-Substituted 1,3,4-Oxadiazoles and 5-Imino-2-Substituted Δ²-1,3,4-Oxadiazolines. A Group of Novel Muscle Relaxants

Synthesis and antibacterial study of some s-substituted aliphatic analogues of 2-mercapto-5-(1-(4-toluenesulfonyl) piperidin-4-yl)-1,3,4-oxadiazole

“…Derivatives of 1,3,4-oxadiazole, aromatic heterocyclic class bearing two nitrogens and one oxygen, have demonstrated a broad spectrum of biological activities including anticonvulsant, antidepressant, anti-inflammatory, antifungal, hypoglycemic, antimitotic, antimicrobial, analgesic, insecticidal, herbicidal and anticancer activities [1][2][3][4][5][6][7][8][9][10][11]. Piperidine, derivatives are known for the therapeutic potential [12].…”

Microwave-assisted solvent free efficient synthesis of 1,3,4-oxadiazole-2(3H)-thiones and their potent in vitro urease inhibition activity

“…The substituted oxadiazoles serve both as biomimetic and reactive pharmacophores. Such compounds offer a privileged motif in medicinal chemistry; such as antidiabetic [22], anticancer [23], antialzimer activity, inhibitors of glycogen synthase kinase-3β [24], insecticidal [25], bactericidal [26], hypoglycemic [27], analgesic, anticonvulsive, antiemetic, diuretic [28], muscle relaxant [29,30], herbicidal [31,32] and fungicidal activity [33,34].…”

Synthesis and Antimicrobial Activity of Oxazolone, Imidazolone and Triazine Derivatives Containing Benzothiophene

“…The benzothiophene nucleus is associated with diverse pharmacological activities such as nervous system depressing, 7 analgesic, 8 herbicidal, 9 muscle relaxant 10 and tranquilizing 11 activities. The synthesis of compounds incorporating oxazolones, imidazolone and triazine moieties has been attracting widespread attention due to their diverse pharmacological properties such as antimicrobial, antiinflammatory, analgesic and antitumor activities.…”