“…The dihydroquinazolinone moiety is present in numerous biologically active molecules with various potential therapeutic effects [1,2,3,4,5,6,7,8,9]. In view of the increasingly widespread applications of dihydroquinazolinone derivatives, many researchers have made great effort to develop these types of compounds using different synthetic methodologies [8,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24], such as by using TiO 2 nanoparticles (TiO 2 NPs) as a catalyst for the synthesis of 2,3-disubstituted dihydroquinazolin-4(1 H )-one derivatives [25]; a metal reduction–condensative cyclization strategy [26]; a three-component reaction of isatoic anhydride with amine and 2-formyl benzoic acid in the presence of montmorillonite K10 as a catalyst [27]; ultrasound irradiation catalyzed by dodecylbenzenesulfonic acid [28]; microwave irradiation in the presence of Amberlyst-15 [29] or Cu-CNTs [30]; and condensation of isatoic anhydride, amine, or ammonium salts with aldehydes or ketones in the presence of p -toluenesulfonic acid [31], citric acid [32], or silica bonded with different acids [33,34,35]. Moreover, the development of a simple, efficient, easy method under environmentally benign conditions for the synthesis of 2,3-dihydroquinazolin-4(1 H )-one derivatives is necessary.…”