2,4‐diamino‐6‐pteridinecarboxaldehyde and an Azobenzene Derivative Are Produced by Uv Photodegradation of Methotrexate

Abstract

Abstract— 2,4‐Diamino‐6‐pteridinecarboxaldehyde, aminopterin and an azobenzene derivative have been identified as methotrexate photoproducts. A mechanism involving photosensitized oxidation by the aldehyde is proposed for the production of these three products.

Photocatalytic degradation of selected anticancer drugs and identification of their transformation products in water by liquid chromatography–high resolution mass spectrometry

“…All the proposed structures are collected in Figure 7, where a tentative transformation route is proposed. Two pteridinic derivatives are known to be formed through a photolytic process [31] but were not identified in our studies.…”

Photochemical release of methotrexate from folate receptor-targeting PAMAM dendrimer nanoconjugate

“…However the HPLC traces also show the appearance of three faster running species at t r = 0.9-1.1 min. We believe that their HPLC and UV/vis profiles are closely related with those of major photodegradation products of MTX which are identified in earlier studies 48,49 as 2,4-diamino-6-pteridinecarbaldehyde, 2,4-diamino-6-pteridinecarboxylic acid, and p-aminobenzoylglutamic acid. In summary, the analysis by UV/vis and HPLC methods demonstrated that UV-A irradiation enabled photochemical release of MTX from 2 (G5-FA 9 -MTX 17 ).…”