2,3-Dihydro-1H-imidazo[1,2-b]pyrazole

Facile synthesis of 1H-imidazo[1,2-b]pyrazoles via a sequential one-pot synthetic approach

“…Among others, anti-inflammatory [37–38], antiviral [28,39] and antidiabetic [40] effects should be mentioned, besides the non-negligible cancer cell growth-inhibitory features of the corresponding compounds [30,34,41–42]. …”

Synthesis of N-Alkyl-2-aryl-5H-imidazo[1,2-b]pyrazol-3-amines by a Three-Component Condensation Reaction

“…7CH arom and 1CH pyrazole ),8.33 (d, 3 J = 8.0 Hz, 2 H, 2CH arom ).13 C NMR (100 MHz, CDCl 3 ): d = 14.26, 24.18, 25.88, 33.14, 58.69, 111.13, 126.95, 127.24, 127.93, 128.98, 129.12, 130.20, 130.79, 140.30, 141.33, 144.04, 156.96, 164.81. Anal.…”

“…Imidazopyrazoles, as unusual fused heterocyclic compounds, are attractive compounds for drug discovery because many compounds incorporating these scaffolds exhibit a wide range of biological, medicinal, and pharmaceutical activities, including antitumor activities, 4 anti-inflammatory activities, 5 antiviral activity against herpes simplex virus type 1, 6 and antineoplastic activity against L1210 leukemia cells. 7 In addition, some compounds of this class show inhibitory effects on deoxyribonucleic acid synthesis, 8 MAP kinase, 5 L1220 tumor-derived ribonucleotide reductase, 9 and ribonucleoside diphosphate reductase, 10 as well as synchronization of human lymphoid cells and HeLa cells.…”

“…Moreover, we found that the presence of an acidic catalyst was essential to obtain a high yield. Next, we attempted to identify the optimal catalyst by screening 0.1 mmol quantities of a number of Lewis or Brønsted acids (Table 2, entries [1][2][3][4][5][6][7][8][9][10][11][12]. The experiments showed that the highest yields were obtained with 4-toluenesulfonic acid.…”

“…7 In addition, some compounds of this class show inhibitory effects on deoxyribonucleic acid synthesis, 8 MAP kinase, 5 L1220 tumor-derived ribonucleotide reductase, 9 and ribonucleoside diphosphate reductase, 10 as well as synchronization of human lymphoid cells and HeLa cells. [11][12] Recently, other members of this group of compounds have been shown to be useful as nonsteroidal agonists and antagonists of the androgen receptor modulators that are useful in the treatment of a variety of diseases.…”