2′3′cyclic nucleotide 3′phosphodiesterase immunohistochemistry shows an impairment on myelin compaction in hypothyroid rats

Barradas, Penha C.; Ferraz, A. S. F. S.; Ferreira, Andréa Alves; Daumas, Regina Paiva; Moura, Egberto Gaspar de

doi:10.1016/s0736-5748(00)00028-9

Cited by 26 publications

(17 citation statements)

References 27 publications

(33 reference statements)

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“…Another possibility is that hypothyroidism affected the formation of auditory startle response neural circuits, which are composed of cochlear root neurons, neurons in the nucleus reticularis pontis caudalis, and spinal motoneurons (Lee, et al, 1996). Thyroid hormones regulate the expression of genes involved in axonal growth, myelination, and synaptic formation (Barradas, et al, 2000;Knipper et al, 1998;Kobayashi et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

“…MMI treatments of 0.001-0.005% are the lowest doses that cause hypothyroidism in adult rats; hence, 0.002% MMI treatment was considered as the low dose in this study (Cooper, et al, 1984). Moreover, treatment with 0.02% MMI from GD 15 to PND 21 affects myelinogenesis in rat brain (Barradas, et al, 2000). Two pups (one male and one female) were sampled from each litter after weaning on PND 21.…”

Section: Subjectsmentioning

confidence: 99%

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Irreversible damage to auditory system functions caused by perinatal hypothyroidism in rats

Wada

Yumoto

Iso

2013

Neurotoxicology and Teratology

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We examined the effect of perinatal hypothyroidism on auditory function in rats using a prepulse inhibition paradigm. Pregnant rats were treated with the antithyroid drug methimazole (1-methyl-2-mercaptoimidazole) from gestational day 15 to postnatal day 21 via drinking water at concentrations (w/v) of 0 (control), 0.002 (low dose), or 0.02% (high dose). Rats from methimazole-treated mothers were tested at ages 1, 6, and 12 months using techniques to examine prepulse inhibition and startle response. The startle stimulus consisted of 40 ms of white noise at 115 dB, whereas the prepulse, which preceded the startle stimulus by 30 ms, consisted of 20 ms of white noise at 75, 85, or 95 dB. When the prepulse intensity was 75 or 85 dB, the high-dose group showed decreased prepulse inhibition percentages compared with the control and low-dose groups. The reduced percentages of prepulse inhibition did not return to control levels over the 12-month study period. In contrast, no differences in prepulse inhibition were observed among the three dose groups when prepulse intensity was 95 dB. Moreover, the high-dose group displayed excessive reaction to auditory startle stimuli compared with the other groups. Reductions in plasma free thyroxine and body weight gain were observed in the high-dose group. We conclude that perinatal hypothyroidism results in irreversible damage to auditory function in rats.

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Section: Discussionmentioning

confidence: 99%

Section: Subjectsmentioning

confidence: 99%

Irreversible damage to auditory system functions caused by perinatal hypothyroidism in rats

Wada

Yumoto

Iso

2013

Neurotoxicology and Teratology

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“…The effects of TH on myelination and development of the central nervous system are particularly well recognized [68] , and TH deficiency during the perinatal period results in severe mental and physical retardation [69] .…”

Section: Programming Thyroid Functionmentioning

confidence: 99%

Neonatal Programming of Neuroimmunomodulation – Role of Adipocytokines and Neuropeptides

Moura¹,

Lisboa²,

Passos

2008

Neuroimmunomodulation

101

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Programming is an epigenetic phenomenon by which nutrition, environment and stress acting in a critical period earlier in life change the organism‘s development. This process was evolutionarily selected as an adaptive tool for the survival of organisms living in nutritionally deficient areas and submitted to stressful conditions. Thus, perinatal malnutrition turns on different genes that provide the organism with a thrifty phenotype. In conditions of abundant supply of nutrients, those programmed organisms can be at risk of developing metabolic diseases (obesity, dyslipidemia, diabetes and hypertension). How nutrition or neonatal stress can program the immune system is less well known. Here, we discuss some of the hormonal and metabolic changes that occur in mothers and neonates and how those factors can imprint hormonal or metabolic changes that program neuroimmunomodulatory effects. Some of these changes involve thyroid hormones, leptin, insulin, glucocorticoids and prolactin as potential imprinting factors. Most of them can be transferred through the milk and may change with malnutrition or stress. We discuss the programming effects of these hormones upon body weight, body composition, insulin action, thyroid, adrenal and immune and inflammatory responses, with special emphasis on leptin, a cytokine that seems to play a central role in these events.

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“…This network regulates the laryngeal, respiratory, and articulatory components of vocalization. Since hypothyroidism alters gene expressions related to myelination or neural network formation (Barradas et al, 2000(Barradas et al, , 2001Kobayashi et al, 2009Kobayashi et al, , 2005, it is possible that the brainstem neural network was impaired and, accordingly, the low-and high-dose groups altered their USVs. This possibility should be investigated in future studies.…”

Section: Other Effects On Vocalizationmentioning

confidence: 99%

Acoustic alterations of ultrasonic vocalization in rat pups induced by perinatal hypothyroidism

Wada

2017

NeuroToxicology

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Perinatal hypothyroidism causes serious damage to auditory functions that are essential for vocalization development. In rat pups, perinatal hypothyroidism potentially affects the development of ultrasonic vocalization (USV) as a result of hearing deficits. This study examined the effect of perinatal hypothyroidism on the development of USVs in rat pups. Twelve pregnant rats were divided into three groups and treated with the anti-thyroid drug methimazole (MMI) via drinking water, from gestational day 15 to postnatal day (PND) 21. The MMI concentration (w/v) was 0% (control group), 0.01% (low-dose group), or 0.015% (high-dose group). After birth, the pups were individually separated from the dam and littermates on PNDs 5, 10, 15, and 20, and their USVs were recorded for 5min. On PNDs 5 and 10, compared with the control group, the low- and high-dose groups exhibited reductions of both frequency-modulated and downward USVs. On PND 15, however, the low- and high-dose groups displayed increases in number, duration, and amplitude of USVs compared with those in the control group. Lower body weights were observed for the low- and high-dose groups than for the control group. Total thyroxine concentrations in plasma were dose-dependently reduced. The onset of auditory functions appeared on PNDs 11-14. Thus, the rat pups were unable to hear externally produced USVs before PND 11. USVs emitted on PNDs 5 and 10 might have been spontaneous and independent of the pups' own or littermate-emitted USVs. The developmental retardation of vocalization-related organs or muscles might underlie the acoustic alterations of USVs on PNDs 5 and 10. The greater number, duration, and amplitude of USVs on PND 15, after which the hearing onset occurred, suggested that the elevation of auditory thresholds occurred as a result of hearing deficits in the low- and high-dose groups. Perinatal hypothyroidism appears to have caused acoustic alterations in the USV development.

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2′3′cyclic nucleotide 3′phosphodiesterase immunohistochemistry shows an impairment on myelin compaction in hypothyroid rats

Cited by 26 publications

References 27 publications

Irreversible damage to auditory system functions caused by perinatal hypothyroidism in rats

Irreversible damage to auditory system functions caused by perinatal hypothyroidism in rats

Neonatal Programming of Neuroimmunomodulation – Role of Adipocytokines and Neuropeptides

Acoustic alterations of ultrasonic vocalization in rat pups induced by perinatal hypothyroidism

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