2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases Serum and Kidney Retinoic Acid Levels and Kidney Retinol Esterification in the Rat

Nilsson, Charlotte B.; Hoegberg, Pi; Trossvik, Christina; Azaı̈s-Braesco, Véronique; Blaner, William S.; Fex, Göran; Harrison, Earl H.; Nau, Heinz; Schmidt, Carsten K.; Bennekum, Ariette M. Van; Håkansson, Helen

doi:10.1006/taap.2000.9059

Cited by 59 publications

(27 citation statements)

References 33 publications

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“…In the present study, RA levels were decreased significantly in a DE-71 concentration-dependent manner, suggesting that the transcription of RA responsive genes may have been altered. Previous experiment with TCDD showed increased serum and kidney RA levels and this was thought to be due to the direct effects of TCDD on the RA synthesizing and catalyzing enzymes (Nilsson et al, 2000). Therefore, due to down-regulation of rdh1 and crbp1a, a limited supply of retinal would likely cause RA concentrations to decrease.…”

Section: Discussionmentioning

confidence: 99%

“…Decreased concentrations of retinol have also been observed in wildlife exposed to polychlorinated biphenyls (PCBs) (Boily et al, 2003;Braathen et al, 2004;Mos et al, 2007); however, there was no change in plasma retinol levels in Arctic grayling exposed to PCBs (Palace et al, 2001). These different responses to toxins may be explained by exposure time, since reductions in retinol contents were observed only at later time-points following 2,3,7,8-tetrachlorodibenzodioxin (TCDD) exposure in rats (Nilsson et al, 2000). A previous study showed that retinol concentrations in the skin, an important target tissue, remain constant, which likely reflects compensatory transfer from fat tissues to maintain physiological functions (Mos et al, 2007).…”

Section: Discussionmentioning

confidence: 99%

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Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae

Chen

et al. 2013

Environmental Toxicology and Pharmacology

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae

Chen

et al. 2013

Environmental Toxicology and Pharmacology

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“…TCDD increased all-trans-RA levels in rat liver and serum [18,19]. In this study, we observed that TCDD could increase the hepatic all-trans-RA levels but did not affect the serum all-trans-RA levels.…”

Section: Discussionmentioning

confidence: 86%

“…Therefore, TCDD may inhibit the vitamin A net accumulation in liver by interference with the dynamic balance between esterification of retinol and hydrolysis of stored retinyl ethers. Because no increased retinyl ester hydrolase activities were observed [19], TCDD most likely inhibits the esterification of retinol. LRAT is considered an important enzyme, which esterifies cytosolic retinol [27] and is regulated by dietary vitamin A or RA [28].…”

Section: Discussionmentioning

confidence: 97%

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice

Yang

Huang

Liu

et al. 2005

J. Biochem. Mol. Toxicol.

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This study aimed to clarify the effects of single and repeated administration of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the activities or expression of some metabolic enzymes of retinoids and the influence of supplemental vitamin A on changed vitamin A homeostasis by TCDD. In Experiment I, the mice were given a single oral dose of 40 mug TCDD/kg body weight, with or without continuous administration of 2,500 IU vitamin A/kg body weight/day, and were killed on day 1, 3, 7, 14, and 28. In Experiment II, the mice were daily given 0.1 microg TCDD/kg body weight, with or without supplemental 2,000 IU vitamin A/kg body weight, and were killed on day 14, 28, and 42. In both experiments, TCDD significantly decreased the hepatic all-trans-retinol level and increased the hepatic all-trans-retinoic acid (RA) content, increased the mRNA and enzymatic activities of retinal oxidase. In TCDD + vitamin A mice, the all-trans retinol content was significantly higher, and the retinal oxidase mRNA was significantly lower on day 3 or 7 in Experiment I and on day 14 in Experiment II, compared to TCDD-treated mice. The induction of the retinal oxidase may contribute to the decrease in hepatic all-trans-retinol level and the increase in hepatic all-trans-RA caused by TCDD. Supplemental vitamin A might decelerate the effect of TCDD on retinal oxidase mRNA.

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“…The activity of enzymes that esterify retinol and hydrolyse retinyl esters such as retinyl ester hydrolase (REH), acyl-CoA:retinol acyltransferase (ARAT) and lecithin:retinol acyltransferase (LRAT) were also shown to be modulated by PCBs and TCDD in fish and laboratory animals ( Fig. 1, points 3, 4 and 8) (Chen et al, 1992;Nilsson et al, 1996;Ndayibagira and Spear, 1999;Nilsson et al, 2000). In addition, some hydroxylated PCB metabolites (HO-PCBs) can interact with transthyretin (TTR), as reported in vivo and in vitro in humans and rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of polychlorobiphenyls, polybromodiphenylethers, organochlorine pesticides and their metabolites on vitamin A status in lactating grey seals

Berghe

Weijs

Habran

et al. 2013

Environmental Research

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a b s t r a c tPolychlorobiphenyls (PCBs), polybromodiphenylethers (PBDEs) and organochlorine pesticides (OCPs), such as dichlorodiphenyltrichloroethane (DDT) and hexachlorobenzene (HCB), are considered as endocrine disruptors in laboratory and wild animals. This study investigated whether these compounds and their hydroxylated metabolites (HO-PCBs and HO-PBDEs) may affect the homoeostasis of vitamin A, a dietary hormone, in the blubber and serum of twenty lactating grey seals sampled at early and late lactation on the Isle of May, Scotland. The effect of naturally produced compounds such as the methoxylated (MeO)-PBDEs was also examined. Vitamin A levels in inner blubber (37 7 9 mg/g wet weight (ww) and 92 7 32 mg/g ww at early and late lactation, respectively) and serum (408 7 143 and 390 7 98 ng/ml at early and late lactation, respectively) appeared to be positively related to SPCBs, SPBDEs and several individual PCB and PBDE congeners in inner blubber and serum. These findings may suggest enhanced mobilisation of hepatic retinoid stores and redistribution in the blubber, a storage site for vitamin A in marine mammals. We have also reported that serum concentrations of SHO-PCBs and 4-OH-CB107 tended to increase with circulating vitamin A levels. Although the direction of the relationships may sometimes differ from those reported in the literature, our results are in agreement with previous findings highlighting a disruption of vitamin A homoeostasis in the blubber and bloodstream following exposure to environmental pollutants. The fact that vitamin A and PCBs appeared to share common mechanisms of mobilisation and transfer during lactation in grey seals (Debier et al., 2004;Vanden Berghe et al., 2010) may also play a role in the different relationships observed between vitamin A and lipophilic pollutants.

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2,3,7,8-Tetrachlorodibenzo-p-dioxin Increases Serum and Kidney Retinoic Acid Levels and Kidney Retinol Esterification in the Rat

Cited by 59 publications

References 33 publications

Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae

Effects of acute exposure to polybrominated diphenyl ethers on retinoid signaling in zebrafish larvae

Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A metabolism in mice

Effects of polychlorobiphenyls, polybromodiphenylethers, organochlorine pesticides and their metabolites on vitamin A status in lactating grey seals

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