2-(3′,4′-Dimethoxybenzylidene)tetralone induces anti-breast cancer activity through microtubule stabilization and activation of reactive oxygen species

Abstract

2-Benzylidene tetralone derivatives are exhibited as potent anti-breast cancer agents through microtubule stabilization and induction of apoptosis through reactive oxygen species.

Paclitaxel-loaded TPGS enriched self-emulsifying carrier causes apoptosis by modulating survivin expression and inhibits tumour growth in syngeneic mammary tumours

“…MMP and ROS production in MDA-MB-231 cells were investigated by utilizing JC-1 (5,5 0 ,6,6 0 -tetrachloro-1,1 0 ,3,3 0 -tetraethylbenzimidazolylcarbocyanine iodide, 10 lg/mL) and H 2 DCFDA (10 lg/mL) (Sigma Aldrich) dye as per reported method [8,13]. Treatment were given to cells as mentioned in previous section and after incubation, cells were washed and stained with respective dyes.…”

“…Syngeneic mammary tumour model in SD rats induced with LA-7 cancer cells was used for the in vivo efficacy studies [13]. Rats were treated with vehicle control (normal saline), blank SEDDS, Taxol (PTX equivalent to 20 mg/kg) and PTX-SEDDS (PTX equivalent to 10 mg/kg) through oral route every 4 days for 21 days.…”

“…Tumour dimensions and body weight were measured as previously reported method at predetermined time intervals. Tumour volume and organ index was calculated by the standard formula [13]. Survival analysis of the tumour-bearing SD rats under treatment was performed and Kaplan-Meier curve was plotted to show the percent survival in all groups.…”

Synthesis and anti-breast cancer activity of novel indibulin related diarylpyrrole derivatives

“…It is the fifth most common cause of death related to cancer and the leading cause of cancer death in women. Women have a 1 in 8 lifetime risk of developing breast cancer and 1 in 35 risk of breast cancer causing death in the US [1][2][3][4]. The rates of breast cancers are increasing, but these rates differ by race and ethnicity.…”

“…Among diverse risk factors concerning developing breast cancer are life style, genetic, environmental and biological factors. There are several strategies to overcome breast cancer including surgery, radiation therapy, chemotherapy, hormonal therapy and targeted therapy, but the morbidity and mortality caused by breast cancer remains high [1,[3][4][5]. Improving the treatment of breast cancer is thus an important scientific and medical goal.…”