2-(2-Phenylethyl)chromone-enriched extract of Chinese agarwood (Aquilaria sinensis) inhibits atherosclerosis progression through endoplasmic reticulum stress-mediated CD36 expression in macrophages

Ma, Jiale; Wang, Lingxiao; Zhao, Yimu; Gao, Yun; Yin, Ziyu; Zhao, Maoyuan; Zhao, Yunfang; Pang, Xueping; Wang, Junjiao; Xue, Weigang; Tu, Pengfei; Li, Jun; Zheng, Jiao

doi:10.1016/j.jep.2023.117411

Cited by 3 publications

(1 citation statement)

References 35 publications

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“…Phenylethyl)chromone-enriched extract of Chinese agarwood (Aquilaria sinensis) inhibits atherosclerosis progression through endoplasmic reticulum stress-mediated CD36 expression in macrophages by (Ma et al, 2024) .Meanwhile, Figure 2 enumerates various document categories. The table shows that the vast majority (83.5%) of the documents are articles.…”

Section: Data Search Strategymentioning

confidence: 99%

Examining the Trend in Agarwood Oil Studies for the 5 Recent Years (2019-2023): A Bibliometric Analysis

YUSOFF,

NURLAILA,

Huzir

et al. 2024

Preprint

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This bibliometric article investigates the burgeoning research landscape surrounding Agarwood oil, derived from the Aquilaria tree species. The historical and cultural significance of Agarwood, coupled with its diverse applications in perfumery, traditional medicine, and religious practices, has fueled a surge in scientific interest. However, a comprehensive understanding of the current state of Agarwood oil research is lacking. This study addresses this gap through a systematic review and bibliometric analysis of scholarly databases. By employing techniques such as co-citation analysis and keyword co-occurrence, the research aims to quantify patterns, relationships, and collaborations within the literature. The methodology involves a focused exploration of a specified timeframe to capture recent developments, with the anticipation that the outcomes will include the identification of key contributors, thematic clusters, and emerging trends in Agarwood oil research. The study is poised to contribute valuable insights for researchers, policymakers, and industry stakeholders, offering a holistic perspective on the interconnectedness of Agarwood oil research and guiding future exploration in this dynamic field.

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Section: Data Search Strategymentioning

confidence: 99%

Examining the Trend in Agarwood Oil Studies for the 5 Recent Years (2019-2023): A Bibliometric Analysis

YUSOFF,

NURLAILA,

Huzir

et al. 2024

Preprint

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The odorants profiles and bioactivities of agarwood essential oils from two germplasm of Aquilaria sinensis trees by different extraction methods

Yan,

Ma,

Chen

et al. 2024

Industrial Crops and Products

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Identification and expression analysis of sesquiterpenes biosynthesis-related genes during the bark regeneration process of Aquilaria sinensis

Yan,

Zhou,

Luo

et al. 2024

Preprint

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Agarwood is a secretion produced by certain trees of the Aquilaria genus in the Thymelaeaceae family after they suffer external damage. It is a mixture formed by the infiltration of various secondary metabolites, including chromones, sesquiterpenes, and resins, into the wood. Agarwood is a precious traditional medicinal material and fragrance, but the molecular mechanisms underlying its formation are not well-understood. In this study, we employed a ring-barking method to remove the bark of Aquilaria sinensis over a large area. During the bark regeneration process, agarwood substances were stably produced alongside the proliferation of secretory cells. After 35 days of implantation, an increase in secretory substances was detected in the regenerated bark. By the 50th day of formation, the ethanol extract content reached 12.9%, increasing to 19.1% by the 135th day. We further identified sesquiterpene synthesis–related genes in A. sinensis. Gene expression profile showed that the expression levels of the genes related to the 1-deoxy-D-xylulose-5-phosphate pathway gradually increased, while the expression levels of the genes related to the mevalonic acid pathway continued to decrease. After 360 days of agarwood formation, we extracted the essential oil from the regenerated cambium layer by supercritical carbon dioxide extraction. We identified 100 characteristic secondary metabolites of agarwood in essential oils through gas chromatography–mass spectrometry (GC–MS) analysis, including 27 sesquiterpenoids. In conclusion, our study provides new clues for a deeper understanding of the molecular mechanisms of agarwood formation and lays the foundation for the breeding of new agarwood varieties.

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2-(2-Phenylethyl)chromone-enriched extract of Chinese agarwood (Aquilaria sinensis) inhibits atherosclerosis progression through endoplasmic reticulum stress-mediated CD36 expression in macrophages

Cited by 3 publications

References 35 publications

Examining the Trend in Agarwood Oil Studies for the 5 Recent Years (2019-2023): A Bibliometric Analysis

Examining the Trend in Agarwood Oil Studies for the 5 Recent Years (2019-2023): A Bibliometric Analysis

The odorants profiles and bioactivities of agarwood essential oils from two germplasm of Aquilaria sinensis trees by different extraction methods

Identification and expression analysis of sesquiterpenes biosynthesis-related genes during the bark regeneration process of Aquilaria sinensis

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