2:0815. BMP-2 Dose Correlates With Increased Postoperative Edema and Swallowing Complications After Cervical Fusion

pHEMA-nHA Encapsulation and Delivery of Vancomycin and rhBMP-2 Enhances its Role as a Bone Graft Substitute

“…Such high initial dosage could also result in local bone overgrowth, inflammation response, periimplant bone resorption, and radically increased risks of postoperative complications [13,35]. Complications related to high-dose rhBMP-2 (up to 2.1 mg/level) when used in anterior cervical fusion included postoperative edema, which resulted in an increased rate of readmission, dysphagia, and reintubations that resulted in tracheotomies [28,35]. Recently, major osteolysis (69%) and back pain were also reported in patients undergoing transforaminal lumbar interbody fusion procedures utilizing higher dosages of rhBMP-2 (4.2-8.4 mg for single-level fusion, 12 mg for multilevel fusion [8]).…”