A Case of Psoas Ossification From the Use of BMP-2 for Posterolateral Fusion at L4–L5

Brower, Richard S.; Vickroy, Nancy M.

doi:10.1097/brs.0b013e31817c4f1c

Cited by 50 publications

(23 citation statements)

References 7 publications

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“…Furthermore, despite recently raised concerns over local and systemic adverse effects (osteolysis, bone resorption, heterotopic calcification, allergic reactions) after BMP use [8,22,25], no such complications were encountered over a minimum followup period of 1 year. The full hematologic, liver, and renal function profile was normal in the followup appointments.…”

Section: Discussionmentioning

confidence: 99%

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Giannoudis

Kanakaris

Dimitriou

et al. 2009

Clin Orthop Relat Res

117

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Combining autologous bone graft and recombinant human bone morphogenetic protein-7 (BMP-7) to treat long-bone fracture aseptic atrophic nonunions theoretically could promote bone healing at higher rates than each of these grafting agents separately. We retrospectively reviewed prospectively collected data on patient general characteristics, clinical outcomes, and complications over 3 years to determine the healing rates and the incidence of complications and adverse events of this ''graft expansion rationale.'' There were 45 patients (32 male) with a median age of 43 years (range, 19-76 years). Minimum followup was 12 months (mean, 24.5 months; range, 12-65 months). There were seven humeral, 19 femoral, and 19 tibial nonunions. The median number of prior operations was two (range, 1-7). All fractures united. Clinical and radiographic union occurred within a median of 5 months (range, 3-14 months) and 6 months (range, 4-16 months), respectively. Thirty-nine (87%) patients returned to their preinjury occupation at a mean of 4.2 months (range, 3-6 months). The median visual analog scale pain score was 0.9 (range, 0-2.8; maximum 10), and the median functional score was 86 (range, 67-95; maximum 100) at the final followup. BMP-7 as a bone-stimulating agent combined with conventional autograft resulted in a nonunion healing rate of 100% in these 45 patients.

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Section: Discussionmentioning

confidence: 99%

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Giannoudis

Kanakaris

Dimitriou

et al. 2009

Clin Orthop Relat Res

117

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“…The clinical implication of the ectopic bone induced by BMP has been extensively studied. Incidence and clinical complications of ectopic bone have been reported in spinal fusion surgeries [8,19,22,50]. With the benefits and complications of BMP-2 still being studied, the indications for its use are still evolving.…”

Section: Introductionmentioning

confidence: 99%

Complications of Recombinant Human BMP-2 for Treating Complex Tibial Plateau Fractures: A Preliminary Report

Boraiah

Paul

Hawkes

et al. 2009

Clin Orthop Relat Res

137

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“…Recombinant human bone morphogenetic protein-2 (rhBMP-2) in combination with an absorbable collagen sponge (ACS) requires a supraphysiologic dose that carries potential complications, including bone resorption, graft migration, hematoma formation, radiculitis, and heterotopic ossification. [5][6][7][8][9][10][11] Other growth factors, such as platelet-rich plasma, have shown a limited efficacy in promoting healing. 12 While some preclinical studies have investigated the potential of allogeneic mesenchymal stem cell (MSC) therapy, efficacy concerns have thus far prevented its introduction into clinical practice.…”

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confidence: 99%

A Comparative Evaluation of Factors Influencing Osteoinductivity Among Scaffolds Designed for Bone Regeneration

Hsu

Ghodasra

Ashtekar

et al. 2013

Tissue Engineering Part A

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Due to differing compositions, synthetic scaffolds developed for bone regeneration vary widely in efficacy. To quantify the impact of such differences on osteoinductivity, numerous parameters were examined. Absorbable collagen sponge (ACS), three ceramic-based carriers (#1-3) of varying compositions, mineralized allograft chips, and an experimental phosphoserine-rich nanofiber scaffold [S(P) gel] were compared in their ability to promote cell adhesion, proliferation/survival, growth factor binding/release, and osteogenic gene expression. Human preosteoblasts were found to adhere most efficiently to the S(P) gel, and the growth/survival was greatest on the S(P) and ACS scaffolds, with minimal growth seen on the allograft and Ceramic #3. In bone morphogenetic protein-2 (BMP-2) binding/release assays, ACS demonstrated a burst release pattern, whereas the allograft and the ceramics inefficiently released BMP-2. The S(P) gel showed the most ideal rates of growth factor binding and release. QPCR analyses showed significant differences in the CXCL12, CXCR4, and RANKL transcripts among the cells grown on these various scaffolds. Although some scaffolds showed an advantage over others in individual parameters, the nanofiber gel appears to provide the optimal balance in the factors important to osteoinductivity evaluated here.

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A Case of Psoas Ossification From the Use of BMP-2 for Posterolateral Fusion at L4–L5

Abstract: BMP-2 can cause heterotopic bone formation when used for posterolateral lumbar fusion.

Cited by 50 publications

References 7 publications

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

The Synergistic Effect of Autograft and BMP-7 in the Treatment of Atrophic Nonunions

Complications of Recombinant Human BMP-2 for Treating Complex Tibial Plateau Fractures: A Preliminary Report

A Comparative Evaluation of Factors Influencing Osteoinductivity Among Scaffolds Designed for Bone Regeneration

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