1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal

Lehtonen, Henna-Maria; Lindstedt, Anni; Järvinen, Riikka; Sinkkonen, Jari; Graça, Gonçalo; Viitanen, Matti; Kallio, Heikki; Gil, Ana M.

doi:10.1016/j.foodchem.2012.10.081

Cited by 36 publications

(15 citation statements)

References 29 publications

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“…The PJ was less effective in terms of preventing lipid peroxidation in vivo, presumably due to the absence of polyphenolics such as anthocyanins and quercetin glycosides as well as their in vivo metabolites. Increased hippuric acid levels after supplementation with PJ are in accordance with results reported by others: the consumption of prunes (Toromanovic et al, 2008), green and black tea (Henning et al, 2013;Mulder, Rietveld, & van Amelsvoort, 2005), cider (DuPont et al, 2002), dried cranberry juice (Valentova et al, 2007), and lingonberries (Lehtonen et al, 2013) resulted in increased concentrations of hippuric acid, mainly in urine. The significant increase is most likely a direct consequence of the concentrations of typical hippuric acid precursors such as phenolic acids and other simple aromatic acids commonly more abundant in prunes and prune juice than in plum juice (Toromanovic et al, 2008).…”

Section: Parameterssupporting

confidence: 91%

Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

Santhakumar

Kundur

Fanning³

et al. 2015

Journal of Functional Foods

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Available online A B S T R A C TThe anti-thrombotic properties of an anthocyanin-rich Queen Garnet plum juice (QGPJ) and anthocyanin-free prune juice (PJ) were studied in this randomised, double-blind, crossover trial. Twenty-one healthy subjects (M = 10, F = 11) consumed QGPJ, PJ or placebo, 200 mL/ day for 28-days followed by a 2-week wash-out period. Only QGPJ supplementation inhibited platelet aggregation induced by ADP (<5%, P = 0.02), collagen (<2.7%, P < 0.001) and arachidonic acid (<4%, P < 0.001); reduced platelet activation-dependent surface-marker P-selectin expression of activated de-granulated platelets (<17.2%, P = 0.04); prolonged activatedpartial thromboplastin clotting time (>2.1 s, P = 0.03); reduced plasma-fibrinogen (<7.5%, P = 0.02) and malondialdehyde levels, a plasma biomarker of oxidative stress (P = 0.016). PJ supplementation increased plasma hippuric acid content (P = 0.018). QGPJ or PJ supplementation did not affect blood cell counts, lipid profile, or inflammation markers. Our findings suggest that QGPJ but not PJ has the potential to significantly attenuate thrombosis by reducing platelet activation/hyper-coagulability and oxidative stress.

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Section: Parameterssupporting

confidence: 91%

Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

Santhakumar

Kundur

Fanning³

et al. 2015

Journal of Functional Foods

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“…One of the first attempts to use NMR in human nutrition was related to the investigation of the impact of soy isoflavone consumption on the biochemical composition of urine (Solanky et al., ). Since then, several nutrition‐related applications of NMR have been reported, mainly focusing on identifying changes in the metabolome as a result of a nutritional approach (Bondia‐Pons et al., ; Chen et al., ; Lehtonen et al., ; Rådjursöga et al., ) or an individual food ingredient (Barbaro et al., ; Massimi et al., ; Picone et al., ). Characteristic projects involve the investigation of the effects of dark chocolate consumption on human metabolism (Martin et al., ), the nutritional intervention of tomato sauce (Bondia‐Pons et al., ), the effect of low and high dairy intake in overweight women (Zheng et al., ), studying the associations between dietary influences and cultural differences (Lenz et al., ), investigating the effects of vegetarian, low meat, and high meat diets (Stella et al., ), and the effects of consuming a Mediterranean diet (Vázquez‐Fresno et al., ).…”

Section: Fundamentals Of Nmr Spectroscopy‐relevance To Food Sciencementioning

confidence: 99%

Nuclear Magnetic Resonance (NMR) Spectroscopy in Food Science: A Comprehensive Review

Hatzakis

2018

Comp Rev Food Sci Food Safe

257

126

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Nuclear magnetic resonance (NMR) spectroscopy is a robust method, which can rapidly analyze mixtures at the molecular level without requiring separation and/or purification steps, making it ideal for applications in food science. Despite its increasing popularity among food scientists, NMR is still an underutilized methodology in this area, mainly due to its high cost, relatively low sensitivity, and the lack of NMR expertise by many food scientists. The aim of this review is to help bridge the knowledge gap that may exist when attempting to apply NMR methodologies to the field of food science. We begin by covering the basic principles required to apply NMR to the study of foods and nutrients. A description of the discipline of chemometrics is provided, as the combination of NMR with multivariate statistical analysis is a powerful approach for addressing modern challenges in food science. Furthermore, a comprehensive overview of recent and key applications in the areas of compositional analysis, food authentication, quality control, and human nutrition is provided. In addition to standard NMR techniques, more sophisticated NMR applications are also presented, although limitations, gaps, and potentials are discussed. We hope this review will help scientists gain some of the knowledge required to apply the powerful methodology of NMR to the rich and diverse field of food science.

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“…J. Kim, Kim, Noh, Hur, Sung, Hwang, et al, 2011; Spagou, Theodoridis, Wilson, Raikos, Greaves, Edwards, et al, 2011), rats (S. H. Kim, Yang, Kim, Kim, Park, & Choi, 2009; Song, Wang, Wang, Tian, Yang, & Kong, 2013) and humans (Lehtonen, Lindstedt, Jarvinen, Sinkkonen, Graca, Viitanen, et al, 2013). Several potential biomarkers of obesity and related diseases, including lysophosphatidylcholines (lysoPCs), fatty acids and branched-amino acids (BCAAs) have been reported.…”

Section: Introductionmentioning

confidence: 99%

A high fat, high cholesterol diet leads to changes in metabolite patterns in pigs – A metabolomic study

et al. 2015

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Non-targeted metabolite profiling can identify biological markers of dietary exposure that lead to a better understanding of interactions between diet and health. In this study, pigs were used as an animal model to discover changes in metabolic profiles between regular basal and high fat/high cholesterol diets. Extracts of plasma, fecal and urine samples from pigs fed high fat or basal regular diets for 11 weeks were analyzed using ultra-high performance liquid chromatography with high-resolution mass spectrometry (UHPLC-HRMS) and chemometric analysis. Cloud plots from XCMS online were used for class separation of the most discriminatory metabolites. The major metabolites contributing to the discrimination were identified as bile acids (BAs), lipid metabolites, fatty acids, amino acids and phosphatidic acid (PAs), phosphatidylglycerol (PGs), glycerophospholipids (PI), phosphatidylcholines (PCs) and tripeptides. These results suggest the developed approach can be used to identify biomarkers associated with specific feeding diets and possible metabolic disorders related to diet.

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1H NMR-based metabolic fingerprinting of urine metabolites after consumption of lingonberries (Vaccinium vitis-idaea) with a high-fat meal

Cited by 36 publications

References 29 publications

Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

Consumption of anthocyanin-rich Queen Garnet plum juice reduces platelet activation related thrombogenesis in healthy volunteers

Nuclear Magnetic Resonance (NMR) Spectroscopy in Food Science: A Comprehensive Review

A high fat, high cholesterol diet leads to changes in metabolite patterns in pigs – A metabolomic study

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